Journal ArticleDOI
Hormesis and bone marrow stem cells: Enhancing cell proliferation, differentiation and resilience to inflammatory stress.
TLDR
In this paper, a detailed assessment of hormetic dose responses by bone marrow stem cells (BMSCs) from a broad range of animal models and humans with particular emphasis on cell renewal (proliferation), cell differentiation and enhancing resilience to inflammatory stress was provided.About:
This article is published in Chemico-Biological Interactions.The article was published on 2022-01-05. It has received 14 citations till now. The article focuses on the topics: Hormesis & Stem cell.read more
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Enhancing health span: muscle stem cells and hormesis
TL;DR: A detailed identification and assessment of hormetic dose responses in animal model muscle stem cells, with particular emphasis on cell proliferation, differentiation, and enhancing resilience to inflammatory stresses are provided and how this information may be useful in preventing sarcopenia.
Journal ArticleDOI
Hormesis and Endothelial Progenitor Cells
TL;DR: These studies demonstrate the capacity of these agents to enhance EPC proliferation and angiogenesis functional applications, having a focus on repairing endothelial tissue damage due to acute injury (e.g., stroke), as well as damage from chronic conditions and normal aging processes.
Journal ArticleDOI
Induced Pluripotent Stem Cells and Hormesis
TL;DR: This paper represents the first assessment of agent-induced hormetic dose responses in induced pluripotent stem cells and their derived cells, and compares with hormetic responses in multiple adult and embryonic stem cells.
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Hormesis and embryonic stem cells
TL;DR: In this article , the authors identify and detailed assessment of hormetic dose responses of embryonic stem cells with particular emphasis on cell renewal (proliferation) and differentiation, underlying mechanistic foundations and potential therapeutic implications.
Journal ArticleDOI
Transfer pattern of hormesis into personal care product mixtures from typical hormesis-inducing compounds.
TL;DR: Zhang et al. as mentioned in this paper investigated the transfer pattern of hormesis into mixtures, which would be an efficient method to identify the potential components that affect hormesis transfer in mixtures.
References
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Journal ArticleDOI
Understanding Adipocyte Differentiation
TL;DR: Characterization of regulatory regions of adipose-specific genes has led to the identification of the transcription factors peroxisome proliferator-activated receptor-gamma and CCAAT/enhancer binding protein (C/EBP), which play a key role in the complex transcriptional cascade during adipocyte differentiation.
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Therapeutic approaches to bone diseases.
Gideon A. Rodan,T. John Martin +1 more
TL;DR: A better understanding of the biology of osteoclasts and osteoblasts is providing opportunities for developing therapeutics to treat diseases of bone, and promoting bone formation with growth factors or hormones is an approach that would be a valuable adjunct therapy for patients receiving inhibitors of bone resorption.
Journal ArticleDOI
Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche
TL;DR: This work has identified a broader spectrum of stem cells influenced by hypoxia that includes cancer stem cells and induced pluripotent stem cells, and elucidate an added dimension of stem cell control within the niche.
Journal ArticleDOI
Mesenchymal stem cells and immunomodulation: current status and future prospects
Fei Gao,Sm M. Chiu,Dal A. L. Motan,Zhao Zhang,L. Chen,Hong-Lin Ji,Hf-F. Tse,Qinf-Ling Fu,Qizhou Lian +8 more
TL;DR: The preclinical and clinical studies of MSCs from different adult tissues are summarized, the current hurdles to their use are discussed, and the future development of pluripotent stem cell-derived M SCs are proposed as an approach to immunomodulation therapy.
Journal ArticleDOI
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes
Felix B. Engel,Michael Schebesta,Mychelle T. Duong,Gang Lu,Shuxun Ren,Jeffery B. Madwed,Huiping Jiang,Yibin Wang,Mark T. Keating +8 more
TL;DR: It is shown that adult mammalian cardiomyocytes can divide and p38 is established as a key negative regulator ofCardiomyocyte proliferation and inhibition of p38 in adult cardiomers promotes cytokinesis.