Showing papers in "Chemistry and Physics of Lipids in 2008"

TL;DR: The experimental results reveal that lipid deposits obtained from aqueous liposome or proteoliposome dispersions are highly efficient for GUV electroformation, related to the ability of such dispersions to produce readily well-oriented membrane stacks.

TL;DR: It is hypothesized that the introduction of DHA-rich domains into the plasma membrane where they coexist with lipid rafts is the origin, in part, of the astonishing diversity of health benefits that accrue from dietary consumption of D HA.

TL;DR: The outcome of this analysis will reveal that changes in hepatic 22:6,n-3 content has a major impact on hepatic lipid and carbohydrate metabolism, and the mechanisms involve 22: 6, n-3 control of several well-known signaling pathways, such as Akt, Erk1/2, Gsk3beta and PKC.

TL;DR: A review of the work published on the use of mass spectrometry in identifying oxidized phospholipids from the different classes using the soft ionization methods (electrospray and matrix-assisted laser desorption ionization).

TL;DR: DHA selectively modulates the subcellular localization of lipidated signaling proteins depending on their transport pathway, which may be universally applied to other lipidated protein trafficking and may allow organ systems such as the colon to optimally decode, respond, and adapt to the vagaries of an ever-changing extracellular environment.

TL;DR: This review divides the effects of lipid peroxidation products into camps, enzymatic and non-enzymatic oxidations, and reports their effects primarily on induction of apoptosis in cancer cells.

TL;DR: Small-angle neutron scattering (SANS) curves of unilamellar dipalmitoylphosphatidylcholine (DPPC) vesicles in 1-60mM CaCl2 were analyzed using a strip-function model of the phospholipid bilayer to determine the fraction of Ca2+ ions bound in the DPPC polar head group region.

TL;DR: The fatty chains in both ozonated oils showed a gradual decrease of unsaturation with the gradual increase of ozonation time, and Ozonation increased the peroxide and acid values for both oils, the increase being higher for soybean oil.

TL;DR: The authors' computational results suggest that low torsional energy barriers, comparable to kT at physiological conditions, for the rotatable bonds in the DHA chain are the key to the differences observed between polyunsaturated and saturated acyl chains.

TL;DR: Differential scanning calorimetry (DSC) indicated that the binding of daptomycin to neutral bilayers occurred through a combination of electrostatic and hydrophobic interactions, while the binding to bilayers containing acidic lipids primarily involved electrostatic interactions.

TL;DR: Evidence that incorporation of PUFAs into membrane lipids of antigen presenting cells (APCs) downregulates APC function is reviewed and it is suggested that membrane modulation of immune cells may be an important and overlooked mechanism of immunomodulation.

TL;DR: Results reveal surprisingly rapid conformational transitions of polyunsaturated chains and existence of weakly specific interactions of DHAn3 with spatially distinct sites on rhodopsin.

TL;DR: In this paper, the authors compared lipid species in monocytes, lymphocytes, granulocytes, platelets and red blood cells (RBC) of healthy volunteers using electrospray ionization tandem mass spectrometry and detected striking differences among the examined blood cells.

TL;DR: The results showed that the cholesterol-lowering effect was similar for sterols and stanol, and the Gibbs energy change for the solubilization of plant sterols/stanols showed a negative value larger than that for cholesterol.

TL;DR: Using small angle X-ray scattering experiments, it is obtained that the monolayer spontaneous curvature of dioleoylphosphatidylglycerol (DOPG) is -1/150+/-0.021 nm(-1) when measured in 150 mM NaCl and that divalent cations can play a significant role in altering curvature elastic stress.

TL;DR: Using a new structural model for optimizing the distribution of hydrophobic lipids, namely triglyceride (TG) and cholesterol ester (CE) molecules, it is revealed that particle size-dependent proportion of these 'core lipids' may locate in the surface of lipoprotein particles.

TL;DR: It was concluded that the free volume rather than hydrophobicity of bilayer is a governing factor in the solute partitioning into lipid bilayers.

TL;DR: A complementary role for 1H NMR spectroscopy as an additional analytical tool in human lipid research is demonstrated in human bone marrow fatty acid composition.

TL;DR: Highly resolved small angle X-ray diffraction experiments performed at equilibrium conditions allowed a reliable decomposition of the lattice spacings into hydrophobic and hydrophilic structure elements as well as the determination of the lipid interface area of the lamellar gel-phase.

TL;DR: V Vesicle size decreased but the zeta-potential remained constant with % DODAB, due to a decrease of counterion binding with vesicle size, which might be important for several biotechnological applications currently being attempted with cationic bilayer systems.

TL;DR: Results suggest that my colic acids can assume a three-dimensional conformation similar to a sterol, which requires that mycolic acid exposes its hydroxyl group and assumes rigidity in its chain structure to generate a hydrophobic surface topology matching that of cholesterol.

TL;DR: Investigation of the antioxidative effect of melatonin on the oxidation of DNA and human erythrocytes induced by 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH) finds that every molecule ofmelatonin can trap almost two radicals in protecting DNA and ery throatcytes.

TL;DR: Taking into account the widespread culinary use of myrtle leaves, the results of the present work qualify the natural compounds semimyrtucommulone and myrtucommul ones as interesting dietary antioxidants with potential antiatherogenicity.

TL;DR: Vesicles prepared from these bolaamphiphiles have the potential to serve as a targeted drug delivery systems with selective decapsulation in the presence of the enzyme acetylcholine esterase, resulting in site-specific release of the drug.

TL;DR: The results show that AmB can initiate a redistribution of the ergosterol in the plane of the membrane, but not of the cholesterol molecules, which might constitute an additional mechanism to explain the activity of the antibiotic.

TL;DR: The acid ceramidase inhibitory activity of octanoylamides, p-tert-butylbenzamides and pivaloylamide of several 2-substituted aminoethanols is reported, and this effect was accompanied with an increase in the amounts of C14, C16 and C18 ceramides, which suggested that these lipids may be responsible for the cytotoxic activity of E-tb.

TL;DR: A scheme is suggested accounting for the absorption of alpha-tocopheryl acetate by enterocytes, as Caco-2 cells showed hydrolytic activity on Tac, and additional cholesterol esterase may be taken up by the cells, thus increasing the rates of intracellular hydrolysis of Tac.

TL;DR: Evidence was put in evidence that cholesterol was present in its free and esterified forms and its total content was measured as ca.

TL;DR: Biological, biochemical and molecular mechanisms supporting the essential function of DHA in neuronal survival and development are described in relation to n-3 fatty acid depleting conditions.

TL;DR: Piceatannol, with the presence of an additional hydroxyl group, showed a better antioxidant effect than resveratrol for a given concentration (competition with the fatty acid to scavenge lipid peroxyl radicals LOO), whereas PDM2 and PDM11 did not exhibit any significant protective effect.