Showing papers in "Epilepsy & Behavior in 2012"

TL;DR: The report's recommendations range from the expansion of collaborative epilepsy surveillance efforts to the independent accreditation of epilepsy centers, to the coordination of public awareness efforts, and to the engagement of people with epilepsy and their families in education, dissemination, and advocacy activities.

TL;DR: MR-guided laser interstitial thermal therapy has a significant potential to be a minimally invasive alternative to more conventional techniques to surgically treat medically refractory epilepsy in children.

TL;DR: Data from structural and functional neuroimaging studies in humans provide a further understanding of potential common pathogenic mechanisms operant in depression and epilepsy that may explain their high comorbidity.

TL;DR: Until diaries are validated as research tools and the regulatory environment becomes clearer, adoption of new types of diaries as markers for a primary study outcome will be cautious.

TL;DR: A seizure prediction algorithm is proposed that combines novel multivariate EEG features with patient-specific machine learning and scales with the number of available EEG signals by discovering the variations in correlation structure among any given set of signals that correlate with seizure risk.

TL;DR: Any further efforts to tease apart the relationships between epilepsy, ID, and autism will have to address head-on the accuracy of diagnosis of all three conditions before it is determined whether there is, indeed, a special relationship between autism and epilepsy.

TL;DR: Patients with epilepsy reported an array of perceived benefits similar to those reported by populations with other diseases, and controlled sharing of health data may have the potential to improve disease self-management of people with epilepsy.

TL;DR: Reduced connectivity of the posterior to the anterior DMN in patients with both right and left TLE is found, however, the posterior and anterior networks were found to be individually preserved.

TL;DR: It is found that seizure numbers significantly decreased upon vitamin D3 supplementation, and it is concluded that the normalization of serum vitamin 25(OH)D level has an anticonvulsant effect.

TL;DR: The first report of the anticonvulsant properties of bisabolene sesquiterpenoids is presented and evidence which warrants further investigation toward the mechanistic understanding of their neuromodulatory activity is provided.

TL;DR: The aims of this paper are to identify factors that influence the psychosocial difficulties that persons with epilepsy experience in their everyday life, to describe their onset and the way they evolve over time, and to analyze the determinants of changes over time and other related variables.

TL;DR: The observed pattern of disruption provides evidence for integration- and segregation-type network abnormalities and supports aberrant network organization among people with IGE.

TL;DR: A new seizure detection method for multi-channel long-term EEG using fractal intercept derived from fractal geometry as a novel nonlinear feature of EEG signals and the relative fluctuation index is calculated as a linear feature.

TL;DR: A consensus strategy is outlined on the identification and treatment of depressive disorders in adult and pediatric patients with epilepsy and the role of depression in the course of PNES and its treatment is discussed.

TL;DR: It is hypothesized that disruptions in GABAergic firing may directly contribute to the poor cognitive outcomes in children with DS, and the therapeutic implications of this possibility are discussed.

TL;DR: A systematic review of the literature on the naming outcomes of ATL finds the absence of structural hippocampal pathology and late-onset epilepsy are the strongest predictors of naming decline.

TL;DR: Although Twitter could be used to disseminate accurate information on seizures and epilepsy, this study suggests that it is currently propagating negative attitudes toward seizures with potential for fueling stigma.

TL;DR: Efforts to improve adherence should focus on provider and healthcare system determinants versus those focused only on the patient, which include non-judgmental communication, patient education, simplification of the dosage regimen with once-daily therapies, and the use of patient reminders.

TL;DR: A 1-year prospective audit of use of a group of PNES-related health care items in patients with newly diagnosed PNES suggests that the relationship between presentation of diagnosis and health care demand reduction is causal.

TL;DR: The mean costs of epilepsy found in the German district of Marburg-Biedenkopf were lower than those found in studies conducted at European epilepsy centers due to the inclusion of patients in all health-care sectors.

TL;DR: Lacusamide, a novel sodium channel blocker (SCB), was investigated in 158 patients with partial-onset epilepsy in the prospective, multicenter, observational, RELACOVA cohort study conducted in Spain and was well tolerated.

TL;DR: Results demonstrate that intrinsic characteristics of a patient population impact what should be considered as minimally important change (MIC) in patients with treatment-resistant partial-onset seizures, a key consideration in the clinical interpretation of QOLIE-31 change scores.

TL;DR: Male gender, older age, higher BMI, hypertension, and dental problems were associated with higher AHI, and males with epilepsy appear at increased risk for OSA, increasing with age and AED load, regardless of gender, BMI, and seizure frequency.

TL;DR: This is the first evidence-based review to synopsize the current PWE and driving literature and to provide recommendation(s) to clinicians and policy makers.

TL;DR: Tolerability of this system in a cross-over controlled trial with 15 healthy subjects and preliminary effects of its use, testing repeated tDCS sessions, in two patients with drug-refractory Continuous Spike-Wave Discharges During Slow Sleep are reported.

TL;DR: It is suggested that patients with PNES may be subject to high levels of emotion dysregulation, severe psychiatric symptomatology and impaired quality of life, or to low emotion Dysregulation characterized by emotional unawareness or avoidance.

TL;DR: Although depression is associated with suicidal ideation, about one-fourth of the suicidal subjects were euthymic or only mildly depressed, and these are not predicted by gender, age, seizure factors, medication toxicity or self-perceived quality of life.

TL;DR: Findings may, in part, explain the negative effects of TPM on cognition and language performance and support the notion that TPM may affect the results of language fMRI lateralization/localization.

TL;DR: This study, the first of its kind, revealed that patients with JME have significant sleep disturbances characterized by excessive daytime sleepiness and disturbed night sleep, despite adequate medications and good seizure control.

TL;DR: Minocycline and other tetracycline-class drugs may offer some degree of anticonvulsant effect in the setting of CNS disease trials, as shown in the 6-Hz seizure model.