Showing papers in "Epilepsy & Behavior in 2018"

TL;DR: This open-label drug trial provides class III evidence for the long-term safety and efficacy of CBD administration in patients with treatment-resistant epilepsy (TRE) associated with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromes.

TL;DR: A state-of-the-art review of recent efforts and journal articles on seizure prediction is presented and some novel ideas for seizure prediction using the increasingly ubiquitous machine learning technology, particularly deep neural network machine learning are presented.

TL;DR: A systematic review of all published observational studies to determine the frequency, correlates, and outcomes of a dual diagnosis of epilepsy and PNES found high heterogeneity means that these pooled estimates should be viewed with caution.

TL;DR: Clinical data that support the device's efficacy in children, adolescents, and adults are reviewed, and its side-effect profile, quality of life and cost benefits, and the impact the device has on sudden unexpected death in epilepsy (SUDEP) are reviewed.

TL;DR: This study highlighted a great interest in the use of wearable technology across epilepsy service users, carers, and healthcare professionals, which was independent of demographic and clinical factors and outpaced data security and technology usability concerns.

TL;DR: Administration of a therapeutic dose of CBD (750 mg) showed significantly low abuse potential in a highly sensitive population of polydrug users.

TL;DR: For the first time, this prospective, open-label safety study of CBD in TRE provides evidence for significant improvements in AEP, CSSS, and SF at 12 weeks that are sustained over the 48-week duration of treatment.

TL;DR: It is proposed that epilepsy be considered as the sum of seizures and comorbidities caused by systemic dysfunction, and that the comprehensive management of epilepsy should also include the management of the systemic dysfunction.

TL;DR: This review summarizes both old and new surgical procedures in epilepsy using an example algorithm, and suggests ablative procedures such as laser interstitial thermal therapy (LITT) or stereotactic radiosurgery (SRS) may be appropriate and avoid craniotomy in many cases.

TL;DR: The findings underline the need for mobile apps to cover broader domains of SM and behavioral change techniques and to be evaluated for outcomes.

TL;DR: The experimental data and the clinical experience using DBS for the treatment of epilepsy are reviewed, and the indication for DBS therapy for epilepsy is granted.

TL;DR: The aim of this review is to review the physiology, pathology, clinical presentation, related ancillary tests, and management of GAD Ab-associated autoimmune epilepsy by searching the keywords and to promote the recognition and the initiation of proper therapy for this condition.

TL;DR: This systematic review identified papers that described epilepsy misconceptions or stigma in sub-Saharan Africa and research interventions focused on reducing these misconceptions and found Scalable approaches to reduce stigma are urgently needed within SSA.

TL;DR: The data show a stagnating cost increase with slightly reduced total costs and balanced direct and indirect costs in patients with active epilepsy, accompanied by an ongoing cost-neutral increase in the prescription of 'newer' and non-enzyme-inducing AEDs.

TL;DR: Cognitive improvements are frequently reported during KD treatment in the domains of alertness, attention, and global cognition, and there are indications that these improvements are caused by both seizure reduction and direct effects of KD on cognition.

TL;DR: There is a need to explore what parent and/or child focused interventions might be useful to reduce the mental health difficulties reported by mothers of young children with epilepsy.

TL;DR: The distribution of AED use likely reflects current prescribing patterns for PWWE cared for in USA tertiary epilepsy centers, which has changed markedly since the turn of the century, but changes in the general population remain uncertain.

TL;DR: The use of developed algorithms for predicting DRE using machine learning methods can ensure that patients with predicted DRE receive specialist care with potentially more aggressive therapeutic interventions from diagnosis, to help reduce the serious sequelae of DRE.

TL;DR: For drug-resistant epilepsy, nonpharmacologic treatments should be considered early rather than late, and situations where resective surgery is likely to result in seizure freedom, resection (standard, laser, or radiofrequency) is preferred.

TL;DR: A review of long-term outcomes is given, highlighting both achievements in terms of efficacy and tolerability and limitations of conclusions thereon related to an uncontrolled data basis and decreasing cohort sizes.

TL;DR: The findings suggest that stigma can be predicted by demographic, illness-related, and psychosocial factors, although associations were found to be highly culturally specific.

TL;DR: Overall, Laser ablation is well-tolerated and offers marked seizure reduction for the majority of patients with MTLE, and 97% of patients achieved >50% seizure frequency reduction.

TL;DR: The point prevalence of MDD is estimated at 21.9% among PWE in epilepsy clinics and is higher in females than in males and indicates a need to pay greater attention to females.

TL;DR: Mental health and quality of life of patient with epilepsy are closely related to the knowledge, attitude, and perceived stigma of the patients, and educating/supporting patients can help increase the mental health andquality of life.

TL;DR: Clinical trial data supporting the safety and efficacy of Responsive neurostimulation is reviewed, and a framework for RNS patient selection is provided, which highlights emerging applications of chronic ECoG, and how the limitations of RNS will inform development of next-generation devices.

TL;DR: The wider potential impact of DS to extend beyond that of seizures is shown, demonstrating that there is a need for additional patient- and caregiver-relevant concepts to be measured in clinical trials to fully identify the value of therapeutic interventions.

TL;DR: Caffeine can increase seizure susceptibility and protect from seizures, depending on the dose, administration type (chronic or acute), and the developmental stage at which caffeine exposure started, in some cases.

TL;DR: The responsive neurostimulator (RNS ®, NeuroPace Inc.) has been available clinically since 2013 for the treatment of medically refractory partial epilepsy and provides on-demand electrical cortical stimulation to reduce seizures.

TL;DR: Electrocorticographic high-γ modulation is a specific but not sensitive method for language localization compared with gold-standard ESM, but ECoG HGM can fairly reliably ascertain electrodes overlying ESM cortical language sites.

TL;DR: E efficacy of artisanal CBD preparations in seizure reduction with few significant side effects is supported, although clobazam may contribute to the sedation seen with concurrent CBD use.