Showing papers in "FEBS Open Bio in 2017"

TL;DR: DMSO was found to be toxic to the hematologic system, and should be taken into account when assessing the infusion effects of cryopreserved PLTs or other blood products requiring DMSO as a vehicle, such as cryop Reserved stem cells, in order to avoid adverse therapeutic effects.

TL;DR: The results indicate that overactivated autophagy accelerates cellular injury after MCAO in rats and that exogenous H2S attenuates cerebral ischemia/reperfusion injury via suppressing overactivated Autophagy in rats.

TL;DR: An essential role for G protein coupling in α7 nAChR function in microglia leading to the regulation of inflammation in the nervous system is indicated.

TL;DR: Results suggest that FABP1 reduction in the liver is an effective approach against NAFLD.

TL;DR: PDGF and Notch signaling pathways participated in the promoting effects of hEPCs/hMSCs coculture, and there was crosstalk between these two signaling pathways.

TL;DR: Characteristic differences in promoter sequences and associated structural properties of the two categories of genes in six different eukaryotes are reported, revealing that while the two classes of gene promoters are distinctly different from each other, the properties are also distinguishable across the six organisms.

TL;DR: This study comparatively analyzed the current PHI networks belonging to DNA and RNA viruses and their human host to get insights into the infection strategies used by these viral groups, and proposes heterogeneous nuclear ribonucleoproteins and transporter proteins as potential antiviral therapeutic targets.

TL;DR: In this article, the expression of miR-944 and its exact role in gastric cancer (GC) remain unknown, and the authors aimed to evaluate whether loss of miRNAs could promote the epithelial-mesenchymal transition (EMT) of GC.

TL;DR: Decreased Wnt/β‐catenin signaling might participate in the pathogenesis of central presbycusis through modulating the expression of Bmi1, a transcription factor implicated in antiaging and resistance to apoptosis.

TL;DR: A node‐based model of G2 checkpoint regulation is proposed, in which the action of the central CDK1–cyclin B1 node is determined by the concerted but opposing activities of the Wee1 and cell division control protein 25C (CDC25C) nodes.

TL;DR: This study shows that CTxB induces local curvature, with the radius of curvature around 36 nm, and points to a generic protein design principle for generating local membrane curvature through specific binding to their lipid anchors.

TL;DR: Structural and phylogeny analyses of these CDPK and CRK genes demonstrate evolutionary conservation in these gene families across H. brasiliensis and other plant species, and suggest that HbCPK and HbCRK genes are important components in growth, development, and stress responses of H. Brasiliensis.

TL;DR: The results showed that IL‐24 could be down‐regulated by miR‐203a‐3p.1 in HCC cells and that miR.1 acted as an onco‐miRNA by targeting IL‐ 24, which indicates thatIL‐24 and miR •203a •3p‐1 may constitute potential therapeutic targets for HCC.

TL;DR: Indoxyl sulfate may induce low‐turnover bone disease in patients with CKD by its direct action on both osteoblasts and osteoclast precursors to suppress bone formation and bone resorption.

TL;DR: An elaborate genome‐scale metabolic model of C. difficile is presented, showing that polysaccharide secretion was coupled to growth even during unstable glucose uptake in minimal medium, and predicts oxidative Stickland reactions and glucose degradation as main sources of energy.

TL;DR: It is found that miRNA profiles in GCF of periodontitis patients are distinct from those of healthy controls, and this findings suggest that a subset of miRNAs inGCF holds potential as a biomarker forperiodontitis.

TL;DR: The down‐regulation of miR‐146a‐5p in HCC has been validated with the most complete data possible and the potential gene signatures, regulatory pathways, and networks identified could prove useful for molecular‐targeted diagnostics and therapeutics.

TL;DR: A validated questionnaire is used to analyze biomedical PhD programs in four representative institutions at Vanderbilt University, University of Manitoba, Karolinska Institutet, and Graz Medical University to reveal that while there is considerable overlap in the aims and content of PhD programs, there are also considerable differences regarding the structure of PhD Programs.

TL;DR: This study revealed the unique distribution of Lewis and Secretor polymorphisms in a large Chinese population, and decoded the combined genotypes of the two CA19‐9‐related genes.

TL;DR: This work has found that the DNA‐binding activity of CTCF is regulated in a phosphorylation‐dependent manner during mitosis, and proposes that the mitotic phosphorylated of the linker domains of CTF is important for the dissociation of C TCF from mitotic chromatin.

TL;DR: It is demonstrated that icariin ameliorates renal damage in IgAN rats via inhibition of NF‐κB‐mediated Nlrp3 inflammasome activation, providing insight into an application of icari in for the treatment of IgAN disease, and represents a novel mechanism behind these effects.

TL;DR: The results indicate that the glutamine pathway is predominant under drought stress in A. annua and a reduction of catabolic gene expression is adopted as a defense strategy in adverse conditions.

TL;DR: Findings reveal Dicer as a new essential player that sustains mESCs self‐renewal and genome integrity by controlling L1s regulation.

TL;DR: Findings provided evidence that cotreatment with melatonin and VPA exerted increased cytotoxicity by regulating cell death pathways in UC3 bladder cancer cells, but the clinical significance of combinatorial treatment still needs to be further exploited.

TL;DR: Ceragenins have the potential to be both topical antimicrobials and wound‐healing adjunct therapeutics, and are tested as mimics of antimicrobial peptides to mitigate preformed biofilms and stimulate wound healing in vitro.

TL;DR: HLJDD and its component herbs could effectively inhibit LPS‐induced AKI in mice by inhibiting NF‐κB and MAPK activation and activating the Akt/HO‐1 pathway, and by markedly ameliorating disturbances in oxidative stress and energy metabolism induced by LPS.

TL;DR: The bidirectional transport of glutamine, glutamate, and aspartate by SLC38A10, and the immunostaining detected in neurons and astrocytes, suggest that SLC 38A10 plays a role in pathways involved in neurotransmission.

TL;DR: It is hypothesized that the antifibrotic effects of cGMP and cGKI‐dependent kinase I (cGKI) are mediated via regulation of the TGFβ signalling pathway, both via ERK and the Smad‐dependent route, and the elucidation of these signalling mechanisms might support the development of new therapeutic options.

TL;DR: It is demonstrated that miR‐29a‐3p suppresses cell proliferation in laryngocarcinoma by targeting PROM1.

TL;DR: Curcumin prominently inhibited gastric cancer cell proliferation and promoted cell apoptosis and caspase‐3 was upregulated by curcumin treatment, which significantly inhibited tumor growth, increased gastric pH, and reduced gastric secretion.