Showing papers in "FEBS Open Bio in 2020"

TL;DR: It is reported that KDM3B, a histone H3 lysine 9 demethylase, can protect against ferroptosis induced by Erastin, an inhibitor of SLC7A11.

TL;DR: The procedure used in this study is a possible strategy for discovering anti‐SARS‐CoV‐2 drugs from drug libraries that may significantly shorten the clinical development period with regard to drug repositioning.

TL;DR: The data reveal that DANCR exerts its function by regulating miR‐33b/MMP16 expression, implying an important role for a lncRNA–miRNA–mRNA functional network and suggesting a novel potential therapeutic target for PC.

TL;DR: It is demonstrated that HSF1 is required for induction of mitochondrial chaperones during the UPRmt, and thus, it may be one of the guardians of mitochondrial function under conditions of impaired mitochondrial proteostasis.

TL;DR: Wang et al. as mentioned in this paper systematically analyzed molecular correlates of bone metastasis by bioinformatics analysis and identified a total of 12 differentially expressed microRNAs (miRNAs) and 102 differentially expressing genes were identified.

TL;DR: The results suggest that CHMP4C contributes to the viability and motility of CC cells by modulating epithelial–mesenchymal transition and may facilitate the identification of novel biomarkers for CC therapy.

TL;DR: AD‐MSCs can differentiate into distinct CAF subtypes depending on the different co‐culture conditions in vitro, and the identification of potential CAF markers may aid in future investigations of the mechanisms underlying the role of CAFs in the tumor microenvironment (TME).

TL;DR: It is demonstrated that miR‐21‐5p can promote the growth of melanoma cells by targeting CDKN2C, which may induce G0/G1 phase arrest of melanomas cells.

TL;DR: It is concluded that lncRNA EGOT may inhibit breast cancer cell viability and migration via inactivation of the Hh pathway through overexpression of EGOT.

TL;DR: It is reported that ROCK inhibition by Y‐27632 reduces levels of IL‐1α, IL-1β, IL‐6 and IL‐8 secreted by senescent normal and dysplastic oral keratinocytes without affecting the permanent cell growth arrest.

TL;DR: BBOX1‐AS1 promotes CRC progression by sponging hsa‐miR‐361‐3p and up‐regulating SH2B1.

TL;DR: It is demonstrated here that PNSs protects against mitochondrial damage induced by cisplatin through HIF‐1α/mitochondria/ROS, and also reduces the levels of ROS, malondialdehyde and nitric oxide and ATP and mitochondrial membrane potential in renal tissues.

TL;DR: A set of personas of the users of biomimetics are developed and a deeper understanding of their needs for the design of the process is offered, including tools and methods.

TL;DR: BEZ235 may exert antitumor effects against TNBC cells by targeting mutp53, and this may have implications for the development of future therapies.

TL;DR: It is concluded that PTX induces HEK293 and 8305C cell apoptosis through the TAK1–JNK activation pathway, potentially highlighting Tak1’s role in chemosensitivity.

TL;DR: The data indicate that TTK is involved in the regulation of gastric cancer proliferation and apoptosis through the Akt‐mTOR pathway.

TL;DR: TYROBP may have potential for diagnosis and treatment of clear cell renal cell carcinoma and is closely related to immune cell infiltration and is coexpressed with Programmed cell death protein‐1(PD‐1) and Cytotoxic T lymphocyte‐associated antigen‐4(CTLA‐4).

TL;DR: The data suggest that alpha‐lipoic acid exerts an anti‐lung cancer effect through mTOR‐mediated inhibition of autophagy, and thus LA may have therapeutic potential for lung cancer management.

TL;DR: Evaluation of the wavelengths of maximal absorption of genetically engineered RH2 pigments representing 13 critical stages of vertebrate evolution revealed that the RH2 pigment of the most recent common ancestor of vertebrates had a λ max of 503 nm, while the 12 ancestral pigments exhibited an expanded range in λmaxs between 474 and 524 nm.

TL;DR: It is shown that GNG12 promotes pancreatic cancer cell growth in vivo and in vitro, and activates nuclear factor‐κB signaling and modulates the immune response.

TL;DR: Analysis of the M.tb proteome and secretome revealed that the PE–PGRS subfamily is enriched for disordered regions and disordered binding sites, pointing to their importance in host–pathogen interactions.

TL;DR: It is reported that shRNA‐mediated knockdown of TRIM66 significantly suppressed viability and proliferation of both PC‐3 and DU145 prostate cancer cell lines and inhibited migration and invasion of prostate cancer cells.

TL;DR: A novel human atrial fibroblast line is established, which displays typical fibro Blast morphology and function comparable to primary cells but with improved proliferation capacity and low spontaneous myofibroblast differentiation, which makes this model suitable for the study of fibrosis mechanisms and for drug screening aimed at developing effective antifibrotic pharmacotherapy.

TL;DR: It is reported that LINC00115 expression is increased in triple‐negative breast cancer tissue compared with matched normal tissue, and LINC0115 knockdown suppresses breast cancer cell migration and invasion, and suggest that Linc00115 promotes breast cancer metastasis through modulating the expression of miR‐7 and KLF4.

TL;DR: The results suggest that coadministration of Hst1 may enhance BMP2‐induced osteogenesis and angiogenesis, and thus may have potential for development into a treatment for large‐volume bone defects.

TL;DR: The data suggest that miR‐155‐5p may suppress the expression of PD‐L1 in LUAD, a key oncogenic microRNA that maintains immune homeostasis and mediates cross‐talk between inflammation and tumorigenesis.

TL;DR: The results indicate that in the context of MM, TFP targets NUPR1, inhibiting cell growth and inducing apoptosis by autophagy inhibition, which could contribute toward efforts for the development of more effective therapies for MM to be tested in future clinical trials.

TL;DR: The proliferation capacities of human embryonic stem cells and human induced pluripotent stem cells were significantly inhibited by ferric ammonium citrate in a concentration‐dependent manner and deferoxamine protected hESCs/hiPSCs against FAC‐induced cell‐cycle arrest.

TL;DR: A novel effect of LIPUS is indicated in regulating the expression of osteoarthritic chondrocyte‐derived VEGFA through the suppression of p38 MAPK activity.

TL;DR: The data suggest that mid‐pregnancy is an ontogenetic window for the sex‐specific programming effects of leptin, and these effects may be exerted via fetal sex-specific placental responses to leptin administration.