Showing papers in "Journal of Laboratory and Clinical Medicine in 2003"

TL;DR: Cardiomyocyte (CM) apoptosis has been reported in a variety of cardiovascular diseases, including myocardial infarction, ischemia/reperfusion, end-stage heart failure, arrhythmogenic right ventricular dysplasia, and adriamycin-induced cardiomyopathy, and the role in the development and progression of cardiac diseases merits further investigation.

TL;DR: The work shows that increased thioredoxin-1 expression is a relatively late event in colorectal carcinogenesis and provides evidence in a small group of subjects with coloreCTal cancer of Dukes stages A through D that thiOREDoxin- 1 expression may be an independent marker of patient prognosis.

TL;DR: It is demonstrated that mesenchymal stem cells can be isolated from human fetal pancreas by means of their adherent ability and that they are capable of self-renewal, propagation, and multipotent differentiation.

TL;DR: Results suggest that hydrogen peroxide is involved in the cisplatin-induced necrosis, whereas hydroxyl radical is responsible for the cisPlatin- induced apoptosis.

TL;DR: The data suggest that the increased XDH and decreased selenium GPx activity observed in the later stages of diabetes leads to enhanced oxidative stress in the heart, kidney, and brain, resulting in secondary organ damage associated with the disease.

TL;DR: What is known of the functions of the polycystins and how this information is providing important insights into the molecular pathogenesis of ADPKD are discussed.

TL;DR: Effective inhibition of cholesterol synthesis and subsequent reduction in serum cholesterol levels by statins lead to increases in serum plant-sterol levels, probably as a result of reduced biliary secretion and enhanced absorption of these sterols.

TL;DR: Findings indicate that Amadori-modified glycated albumin modulates macrophage cell biology independent of high glucose concentration, and activates RAW cell ERK and promotes ERK-dependent increases in TGF-beta(1) production, oxidative stress, and NF-kappa B activation.

TL;DR: The trientine/zinc combination therapy should be the standard for initial treatment of liver failure in Wilson's disease because its efficacy is equal or slightly superior to that of penicillamine and because it has a much lower incidence of side effects.

TL;DR: It is concluded that differences in gene expression can be detected between leiomyomas and normal myometrium and that these changes in gene Expression may yield clues to the pathophysiology of this common tumor.

TL;DR: Assessment of associations of IIH with coagulation disorders and with PCOS in 38 women with well-documented IIH found 15 women were found to have PCOS; 14 of them were obese, with a body-mass index (BMI) greater than 30 kg/m(2), and 10 were extremely obese.

TL;DR: It is now clear that CFTR genotype alone does not account for the wide diversity in CF pulmonary phenotype and evidence is accumulating that secondary genetic factors separate from the CFTR locus significantly influence the severity of CF lung disease.

TL;DR: These studies provide unequivocal evidence that CEOT-associated amyloid consists of a unique and previously undescribed protein that is provisionally designate APin.

TL;DR: Activation of PPAR-gamma by 15d-PGJ2 inhibits DNA-binding activity of the transcription factors Cbfa1 and NF-kappaB, leading to diminished expression of osteoblast/stromal differentiation markers.

TL;DR: The view that treatment with REPS ameliorates the hepatic inflammatory response and decreases hepatocellular injury in mice subjected to acute alcohol intoxication is supported.

TL;DR: An exaggerated proliferative response to products released by microorganisms present in oral ulcers may play a role in Behcet's disease and gammadelta T-cells are expanded in BD PBMCs during active disease.

TL;DR: It is hypothesized that the activities of fibrotic and inflammatory cytokines are also subject to modulation by the availability of copper in a manner similar to angiogenic cytokines.

TL;DR: It was found that the RBC life span of 40 healthy volunteers averaged 122 +/- 23 days, a value comparable to that obtained with complex cohort labeling methods, and the ability of this simple technique to detect increased RBC turnover was demonstrated in 4 subjects being treated with ribavirin and interferon for hepatitis C.

TL;DR: This study reports for the first time the apparent interaction of n-3 fatty acids and nitric oxide on Hcy metabolism and changes in total Hcy and NO(x) plasma concentrations observed after 8 weeks of FO were found to be significantly correlated.

TL;DR: Although postprocedure bacteremia is not uncommon, it seldom results in infectious complications and standard infection-control recommendations are important in protecting both patients and health-care providers.

TL;DR: The results show that H1-A inhibits cell proliferation and promotes the apoptosis of interleukin (IL)-1- and platelet-derived growth factor (PDGF)-BB-activated human mesangial cells in vitro, and that Bcl-2 and BCl-XL were probably among these proteins.

TL;DR: RHDV infection reproduces clinical, biochemical, and histologic features of the FLF syndrome and satisfies criteria for a suitable animal model.

TL;DR: A simple, accurate, and reproducible method for measuring fecal 3alpha-hydroxy bile acids that agreed well with values obtained with the use of gas chromatography-mass spectrometry is developed, both in normal subjects and in patients with malabsorption syndromes.

TL;DR: Electrocardiograms and recorded action potentials from the anterior surface of 9 iron-overloaded and 9 age-matched control ventricular-paced, Langendorff-perfused gerbil hearts showed abnormal impulse conduction may be a mechanism of increased arrhythmia vulnerability in iron- overload cardiomyopathy.

TL;DR: More recently recognized endocrine actions of aldosterone include induction of Mg(2+) efflux in exchange for Na(+) in such nonepithelial cells as peripheral-blood mononuclear cells and influence on epithelial cells of the choroid plexus.

TL;DR: Investigation of the time course of electrocardiographic changes in the Mongolian gerbil model of iron overload and the effects of the iron chelator deferoxamine (DFO) shows that survival of iron-overloaded gerbils is dose-dependent, and it is speculated that DFO chelates a small iron pool located within the cytoplasm of Iron- overloaded cardiomyocytes.

TL;DR: In patients with Wilson's disease, the concentration of reduced glutathione was lower than that in patients with viral hepatitis and as high as that in subjects with alcoholic liver damage, while malondialdehyde levels were low, but when zinc- and penicillamine-treated patients were considered separately, only the former had low malondialsde Hyde levels.

TL;DR: New knowledge about bile-salt catabolic end products of cholesterol should spawn pharmacologic discoveries that modulate nuclear receptors for the treatment of disorders of cholesterol homeostasis.

TL;DR: Data indicate the UGT1A promoter polymorphism is a powerful nonglobin genetic modifier in SCA that influences serum bilirubin both at baseline and on hydroxyurea therapy, and may influence the ability of hydroxyUREa to prevent gallstone formation in patients with SCA.

TL;DR: It is proposed that the differential effect of low-dose DHA vs EPA in suppressing MC mitogenesis is related to down-regulation of ERK and cyclin E activity and to induction of p21.