Showing papers in "Molecular Oncology in 2007"

TL;DR: In this paper, a large-scale comparison of the transcriptional profiles and 3D cell culture phenotypes of a substantial panel of human breast cancer cell lines is presented, showing that consistent differences in genes encoding signal transduction proteins emerge when even tumor cells are cultured in 3D microenvironments.

TL;DR: Altered expression and mutations of genes that encode HDACs have been linked to tumor development since they both induce the aberrant transcription of key genes regulating important cellular functions such as cell proliferation, cell‐cycle regulation and apoptosis.

TL;DR: The presence of HPV‐16, but not viral load, in tonsillar cancer was shown to be a favourable prognostic factor for clinical outcome, and E6 and/or E7 were expressed in almost all assessable HPV‐ 16 positive cases, supporting an oncogenic role of HPV•16 in tonsilar cancer.

TL;DR: This review summarizes current knowledge on how genetic alterations in oncogenes or tumour suppressor genes, as well as epigenetic changes, can be exploited in the clinics as biomarkers for cancer detection, diagnosis and prognosis and proposes a rationale for identifying alterations that may have a functional impact within a background of “passenger” alterations.

TL;DR: It is suggested that macrophage‐produced VEGF regulates malignant progression through stimulating tumor angiogenesis, leukocytic infiltration and tumor cell invasion.

TL;DR: It is suggested that DTC in BM differentially distinguishes clinical outcome in patients with luminal A type tumors and that D TC‐associated gene expression analysis may identify genes of potential importance in tumor dissemination.

TL;DR: The goal of treatment tailoring or personalized medicine is the identification of the best type of therapy for the individual patient and the development of drugs targeting specific characteristics of tumour cells.

TL;DR: It is reported here that mice lacking Cdk4 and Cdk2 complete embryonic development to die shortly thereafter presumably due to heart failure, however, conditional ablation of C DK2 in adult mice lackingCdk4 does not result in obvious abnormalities and these double mutant mice recover normally after partial hepatectomy.

TL;DR: The findings indicate that the genetic program encoding metastasis is implemented progressively over time although, occasionally, this evolution can occur rapidly, early in the life of the neoplasm.

TL;DR: Advances in mass spectrometry technologies and bioinformatics tools provide a tremendous opportunity to qualitatively and quantitatively interrogate dynamic protein–protein interactions and differential regulation of cellular signaling pathways associated with tumor development.

TL;DR: The recent application of Trastuzumab, an antibody to a receptor tyrosine kinase, in adjuvant breast cancer therapy marks the beginning of a new phase in cancer treatment.

TL;DR: This work has shown that Chromatin immunoprecipitation (ChIP) can yield all ER genomic target sites and Coupling of ChIP with genome‐wide tiling arrays allows for the genome-wide unbiased identification of direct ER target sequences.

TL;DR: This review highlights the current knowledge of structural/phylogenetic features, functional role and regulatory/signaling mechanisms of the Kallikrein‐related peptidase family, the largest contiguous cluster of proteases in the human genome.

TL;DR: It is found that in cell models that undergo both cell cycle arrest and epithelial–mesenchymal transition (EMT), ectopic Meox2 failed to induce EMT and inhibited the proper EMT response to TGF‐β, which is primarily involved in the T GF‐β tumor suppressor pathway.

TL;DR: A high‐density antibody microarray used to evaluate large numbers of candidate ovarian cancer serum biomarkers was shown to be useful for evaluation of individual antibodies for comparative analysis, such as with disease classification, and biomarker validation and discovery.

TL;DR: Keratin23 impaired the proliferation of human colon cancer cells significantly, leading to cell death in micros satellite‐instable but not microsatellite‐stable cell lines, while COS7 cells experienced multiple nuclei and apoptosis.

TL;DR: Analysis of 24 selected SA samples with apocrine metaplasia revealed non‐obligate putative apocrine precancerous lesions that displayed some, or in same cases all the three markers associated with pure invasive apocrine carcinomas, as well as novel phenotypes for ME and some luminal cells characterized by the expression of cytokeratin 15.

TL;DR: This method was used to profile the levels of 14 different cytokines, acute‐phase reactants, and other cancer markers in plasma from mouse models of intestinal tumors and their wild‐type littermates, using as little as 1.5μl of diluted plasma per assay.

TL;DR: The finding of a subset of breast carcinomas characterized by expression of CK15 is reported, finding cells with a very similar phenotype to the CK15+/CK19+ progenitor cells were observed in a juvenile fibroadenoma as well as in the large collecting ducts of the breast.

TL;DR: The study indicates that the cellular DNA replication factor MCM7 is involved in prostate cancer (CaP) andMCM7 gene expression was reduced by GTCs and these results suggest a possible role of G TCs in CaP chemoprevention in which MCM 7 plays a critical role.

TL;DR: A slide configuration where junctional communication can be examined in the absence of an upper electrode is described, where cells are grown on two co‐planar electrodes separated by a barrier which diverts the electric field, rendering it vertical to the cell layer.

TL;DR: Results show that CTC keep a significant prognosis value at long term on high risk breast cancer patients, that MUC1 and CK19 have similar long term impact, and that a double detection does not improve the prognostic value of CTC.

TL;DR: The discovery of two alternatively spliced variants of TIMP‐1 mRNA lacking exon 2 and 5 were identified in human cancer cell lines by RT‐PCR, detected in extracts from 12 colorectal cancer tissue samples.

TL;DR: As was actually proposed in 2002, the early events do not per se create invasive or metastatic phenotypes or, indeed, necessarily have any immediate effects on cell-biological phenotypes related to invasion and metastasis; instead, these early events simply set the stage for the subsequent development of these malignant phenotypes many years later.

TL;DR: The National Center for Biotechnology Information's dbSNP was mined for polymorphisms located within the kallikrein (KLK) locus using custom‐designed “ParSNPs” and “LocusAnnotator” software tools to assist in the informed selection of KLK polymorphisms for future association and biochemical studies in relation to disease.

TL;DR: EU cancer research will be addressed within the reinforced efforts in the areas of pharmaceutical and technological developments as well as common aetiological mechanisms of diseases that the 7th Framework Programme will undertake.

TL;DR: In inner Mongolia, 4500 people die of cancer, mostly of the liver, per year; in Australia skin cancers rarely seen in the rest of Asia dominate, thanks to its relatively recently arrived non-Asian population spending too much time under the hot southern sun; Naturally, cancer research dollars follow cancer rates.

TL;DR: Patient groups exist at all levels, at the local level, national level and international level, and all need to work together to influence issues, says Kathy Redmond, editor of Cancer World.

TL;DR: Overall European cancer funding lacks any real co-ordination, and member states need to be taking some responsibility, says Philippe Autier from the International Agency for Research on Cancer.

TL;DR: Seven years ago, when Dr. Brian Druker announced the spectacular first results from a phase I trial of imatinib mesylate (Glivec) to an expectant audience at the 91st American Association for Cancer Research annual meeting, the translational research community gained its first major success story.