Journal ArticleDOI
Assessment of the interleukin 1 gene cluster and other candidate gene polymorphisms in host susceptibility to tuberculosis.
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TLDR
Genetic susceptibility to tuberculosis among Gambians may be partly determined by genes in the IL1 gene cluster on chromosome 2, according to a study of tuberculosis cases and healthy blood donor controls.About:
This article is published in Tubercle and Lung Disease.The article was published on 1998-01-01. It has received 146 citations till now. The article focuses on the topics: Interleukin & Candidate gene.read more
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Journal ArticleDOI
Tuberculosis and Chronic Hepatitis B Virus Infection in Africans and Variation in the Vitamin D Receptor Gene
R. Bellamy,C Ruwende,Tumani Corrah,Keith P. W. J. McAdam,Mark Thursz,H. C. Whittle,A. V. S. Hill +6 more
TL;DR: Variation in the vitamin D receptor gene was typed in 2015 subjects from large case-control studies of three major infectious diseases: tuberculosis, malaria, and hepatitis B virus, and homozygotes for a polymorphism at codon 352 (genotype tt) were significantly underrepresented.
Journal ArticleDOI
The role of IL-10 in immune regulation during M. tuberculosis infection.
TL;DR: It is proposed that IL-10 is linked with the ability of Mtb to evade immune responses and mediate long-term infections in the lung.
Journal ArticleDOI
Influence of Polymorphism in the Genes for the Interleukin (IL)-1 Receptor Antagonist and IL-1β on Tuberculosis
Robert J. Wilkinson,Punita Patel,Martin J. Llewelyn,Christina S. Hirsch,Geoffrey Pasvol,Georges Snounou,Robert N. Davidson,Zahra Toossi +7 more
TL;DR: The polymorphism at the IL-1 locus influences the cytokine response and may be a determinant of delayed-type hypersensitivity and disease expression in human tuberculosis.
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Role of innate cytokines in mycobacterial infection
TL;DR: Current information on the role of the major innate cytokine pathways both in controlling initial infection as well as in promoting and maintaining adaptive T-cell responses that mediate host resistance or immunopathology is reviewed.
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Ethnic-Specific Genetic Associations with Pulmonary Tuberculosis
TL;DR: The novel pattern of genetic associations with susceptibility and resistance to TB detected in Cambodia is consistent with the conclusion that unique environmental and natural selective factors have resulted in the development of ethnic-specific host genetic factors associated with TB susceptibility and Resistance worldwide.
References
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Journal ArticleDOI
Interleukin-1 and interleukin-1 antagonism.
TL;DR: The recent cloning of a naturally occurring IL-1 receptor antagonist (IL-1ra) has opened new experimental and clinical approaches and reduced the severity of diseases such as hemodynamic shock, lethal sepsis, inflammatory bowel disease, experimental arthritis, and the spontaneous proliferation of human leukemic cells.
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An investigation of polymorphism in the interleukin-10 gene promoter.
TL;DR: Three single base pair substitutions in the IL-10 gene promoter are identified and it is investigated whether this polymorphism correlates withIL-10 protein production in vitro.
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Macrophage deactivation by interleukin 10.
TL;DR: In this article, the authors showed that the IL-10 was exceedingly potent at suppressing the ability of mouse peritoneal macrophages (m phi) to release tumor necrosis factor alpha (TNF-alpha).
Journal Article
Global tuberculosis incidence and mortality during 1990-2000.
TL;DR: In WHO's South-East Asian Region and in Central and South America the age-specific incidence rates are expected to fall during 1990-2000, but at a slower rate than in previous years because of the expected increase in HIV seroprevalence.
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Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans.
Richard Bellamy,Cyril Ruwende,Tumani Corrah,Keith P. W. J. McAdam,Hilton Whittle,Adrian V. S. Hill +5 more
TL;DR: Genetic variation in NRAMP1 affects susceptibility to tuberculosis in West Africans, and subjects who were heterozygous for twoNRAMP1 polymorphisms in intron 4 and the 3' untranslated region of the gene were particularly overrepresented among those with tuberculosis.