Showing papers in "Virus Research in 1992"

TL;DR: During the analysis of nucleotide sequences of cDNAs of 40 isolates of hepatitis C virus (HCV-J), it was confirmed that two hypervariable regions (HVR1 and HVR2) were present in this amplified region, as described in the previous report.

TL;DR: The genome of Marburg virus (MBG), a filovirus, is 19.1 kb in length and thus the largest one found with negative-strand RNA viruses, and the data support the concept of a common taxonomic order Mononegavirales comprising the Filoviridae, Paramyxoviraceae, and Rhabdovirales families.

TL;DR: Six distinct regions within the capsid precursors were identified based on amino acid sequence alignment analysis of the two SMSV serotypes with FCV and the rabbit hemorrhagic disease virus (RHDV) capsid protein.

TL;DR: The Japanese and American HCVs are genetically distinguishable, supporting the earlier prediction that these two HCVs could be classified as different subtypes.

TL;DR: Inhibition of the function of the M2 protein by amantadine can cause a conformational change in the haemagglutinin (HA) of H7 influenza A viruses and the consequent expression of the low pH form of the glycoprotein on the surface of virus-infected cells, demonstrating the important relationship between the structural and functional properties of these two proteins.

TL;DR: Two sets of polymerase chain reaction (PCR) primer pairs specific for the genotype of wild poliovirus type 3 recently endemic to Mexico and Guatemala are prepared to facilitate identification of wildPolioviruses present in both clinical and environmental samples.

TL;DR: The completed sequence of the arenavirus, lymphocytic choriomeningitis virus, revealed a new gene encoding a small protein with a single zinc-binding domain, p11, which is a hydrophobic protein associated with the nucleocapsid of the virion core.

TL;DR: Overall, the nucleocapsid protein is highly variable both in size and composition between coronavirus major antigenic groups but is conserved within these groups.

TL;DR: Cold-passaged mutants derived from the JS strain of wild type wt parainfluenza type 3 virus are being evaluated as candidate live virus vaccines and the cp45 virus appears to be the most promising vaccine candidate for humans.

TL;DR: Comparison of the 5'UTR of C-S8c1 or R100 RNA with that of other FMDV serotypes and subtypes indicates the presence of block deletions (or insertions) which do not correlate with the serological classification of F MDV.

TL;DR: The experiments suggest that the advantage of IgA for protecting mucosal surfaces, such as the respiratory tract, relates to the presence of a specialized mechanism for transporting oligomeric IgA across epithelial surfaces and supports the rationale for active mucosal immunization protocols designed to generate an IgA response.

TL;DR: Influenza virus RNA polymerase was reconstituted by mixing the three P proteins in a urea solution and then dialyzing against a reconstitution buffer and was able to transcribe model RNA templates.

TL;DR: Observations confirm that multiple lineages of RS virus co-circulate locally, and show that very similar viruses are present simultaneously in widely separated countries.

TL;DR: The predominant reassociation of neutral DNA genomic markers following double infection of Sf9 cells by pairs of parental AgMNPVs indicates the potency of intrapopulation genetic recombination in a wild isolate to redistribute DNA sequences in the genetic pool of this virus.

TL;DR: The antigenic epitopes of the 'a' determinant have been analysed by competitive inhibition assays and by binding studies to synthetic peptides using a panel of monoclonal antibodies prepared against HBsAg, all of which are shown to recognise the common group determinant.

TL;DR: The amino acid sequences deduced from all currently available nucleotide sequences of hantaviruses are compared, allowing easy identification of conserved and unique gene regions.

TL;DR: Results suggest that polymerase PB1 subunit and the non-structural proteins could be involved in the nuclear targeting or nuclear retention of influenza polymerase PA protein.

TL;DR: The RD variants of group B coxsackieviruses differ from their parental strains in having the ability to replicate in a human rhabdomyosarcoma cell line, RD, and it is shown that the RD phenotype of CB3NRD maps in the P1 region.

TL;DR: A recombinant baculovirus (vAc-gB1) was constructed which expressed the glycoprotein B (gB) gene of herpes simplex virus type 1 (HSV-1) as mentioned in this paper.

TL;DR: Data presented in this manuscript indicate that the observed effect on B- and T-cell responses might not be solely caused by removal of the antigenic load due to residual maternal antibodies.

TL;DR: Evidence of the genetic instability of the A/Korea/82 CA M-SGR is presented, specifically, an extragenic mutation that results in loss of the ATT phenotype, and data suggest that the change in the amino acid sequence of the M gene product from the A-Ann Arbor/6/60 WT to CA virus is not responsible for theATT phenotype.

TL;DR: It was shown that the ICP6 promoter responded very weakly to the alpha-transinducing factor (TIF) in the absence of all other viral gene products, but much more strongly to immediate early proteins.

TL;DR: PCR can be used as an adjunct test with serological method(s) or an independent test for diagnosis and for typing of new isolates of Hantaviruses.

TL;DR: It is indicated that the three ORFs encoded by the 3'-terminal end of the LDV genome are expressed via the three smallest mRNAs (mRNAs 6–8) of the seven subgenomic m RNAs of LDV (m RNAs 2–8), which range in size from about 0.8 to 3.6 kb.

TL;DR: The specificity of CCH2 was determined by screening a recombinant lambda-gt11 cDNA gene bank from HCMV-infected fibroblasts, and the subcellular localization of p52 in infected cells was analyzed.

TL;DR: These analyses defined the relative molecular mass and physical size of the Creutzfeldt-Jakob disease (CJD) agent with greater precision than previously possible and further solidifies the concept of an infectious agent that resembles a viral core rather than a simple protein.

TL;DR: Phylogenetic analyses indicated that B TV-10 and -11 are very closely related and BTV-2 is the distantly related serotype of the five US bluetongue virus serotypes.

TL;DR: Data presented confirm that a prolonged treatment with acyclovir can easily select ACV-r HSV-2 isolates carrying a TK- phenotype caused by a frameshift mutation.

TL;DR: Support is provided for SVV infection of non-human primates as a model for VZv infection of humans and the location of specific SVV genes may be predicted from the known map positions of homologous VZV genes.

TL;DR: Differences in nucleotide and amino acid sequence between the JS strain of human parainfluenza virus type 3 and the previously sequenced prototype PIV3 strain are compatible with efficient replication in vivo.