Journal ArticleDOI
1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.
Zhi Xu,Shi‐Jia Zhao,Yi Liu +2 more
TLDR
This review emphasizes the recent advances in 1,2,3-triazole-containing hybrids with anticancer potential, covering articles published between 2015 and 2019, and the structure-activity relationships, together with mechanisms of action are discussed.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2019-12-01. It has received 253 citations till now.read more
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A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications.
Nagaraju Kerru,Lalitha Gummidi,Suresh Maddila,Kranthi Kumar Gangu,Sreekantha B. Jonnalagadda +4 more
TL;DR: This review highlights the trends in the use of nitrogen-based moieties in drug design and the development of different potent and competent candidates against various diseases.
Journal ArticleDOI
Cu(I)-Catalyzed Click Chemistry in Glycoscience and Their Diverse Applications.
Anand K. Agrahari,Priyanka Bose,Manoj K. Jaiswal,Sanchayita Rajkhowa,Anoop S. Singh,Srinivas Hotha,Nidhi Mishra,Vinod K. Tiwari +7 more
TL;DR: In this article, a review highlights the successful development of CuAAC or click chemistry in emerging areas of glycoscience, including the synthesis of triazole appended carbohydrate-containing molecular architectures (mainly glycohybrids, glycoconjugates, glycopolymers, glycopeptides and glycoproteins, glycolipids, glycoclusters, and glycodendrimers).
Journal ArticleDOI
Artemisinin-derived hybrids and their anticancer activity.
TL;DR: Artemisinin-derived compounds, bearing a peroxide-containing sesquiterpene lactone moiety, could form free radicals with high reactivity and possess diverse pharmaceutical properties including in vitro and in vivo anticancer activity besides their typical antimalarial activity as discussed by the authors.
Journal ArticleDOI
Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview
Dimitris Matiadis,Marina Sagnou +1 more
TL;DR: A comprehensive account of the compounds containing the pyrazoline nucleus will be provided, with emphasis on recent examples from the literature and on the work of research groups that have played a key role in the development of this field.
Journal ArticleDOI
1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).
TL;DR: This review is an endeavour to highlight the current scenario of 1,2,3-triazole-containing hybrids with potential anti-MRSA activity, covering articles published between 2010 and 2020.
References
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Journal ArticleDOI
Glycosylation in cancer: mechanisms and clinical implications
Salomé S. Pinho,Celso A. Reis +1 more
TL;DR: The roles of glycans are highlighted by the fact that alterations in glycosylation regulate the development and progression of cancer, serving as important biomarkers and providing a set of specific targets for therapeutic intervention.
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Hybrid molecules with a dual mode of action: dream or reality?
TL;DR: In order to obtain new antimalarial drugs that are affordable and able to avoid the emergence of resistant strains, the authors developed hybrid molecules with a dual mode of action able to kill multiresistant strains by oral administration.
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Medicinal attributes of 1,2,3-triazoles: Current developments
TL;DR: The present work aims to summarize the current approaches adopted for the synthesis of the 1,2,3-triazole and medicinal significance of these architectures as a lead structure for the discovery of drug molecules such as COX-1/COX-2 inhibitors, HIV protease inhibitors, CB1 cannabinoid receptor antagonist and much more which are in the pipeline of clinical trials.
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Artemisinin—A Gift from Traditional Chinese Medicine to the World (Nobel Lecture)
TL;DR: The important role played by traditional Chinese medicine in the discovery of artemisinin is described by Y. Tu in her Nobel Lecture.
Journal ArticleDOI
Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells
Valentina Zuco,Rosanna Supino,Sabina C. Righetti,Loredana Cleris,Edoardo Marchesi,Carlo Gambacorti-Passerini,Franca Formelli +6 more
TL;DR: The data support further preclinical studies of betulinic acid not confined to melanoma and neuroectodermal tumors independently of p53 status, and support the antineoplastic activity of this drug.