Journal ArticleDOI
Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells
Valentina Zuco,Rosanna Supino,Sabina C. Righetti,Loredana Cleris,Edoardo Marchesi,Carlo Gambacorti-Passerini,Franca Formelli +6 more
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TLDR
The data support further preclinical studies of betulinic acid not confined to melanoma and neuroectodermal tumors independently of p53 status, and support the antineoplastic activity of this drug.About:
This article is published in Cancer Letters.The article was published on 2002-01-10. It has received 458 citations till now. The article focuses on the topics: Betulinic acid & Neoplastic cell.read more
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Targeting mitochondria for cancer therapy
Simone Fulda,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Guido Kroemer,Guido Kroemer,Guido Kroemer +6 more
TL;DR: The mitochondrial metabolism of cancer cells is deregulated owing to the use of glycolytic intermediates, which are normally destined for oxidative phosphorylation, in anabolic reactions and activation of the cell death machinery by stimulating mitochondrial membrane permeabilization could therefore be promising therapeutic approaches.
Journal ArticleDOI
Pharmacological activities of natural triterpenoids and their therapeutic implications
Petr Dzubak,Marian Hajduch,David Vydra,Alica Hustova,Miroslav Kvasnica,David Biedermann,Lenka Marková,Milan Urban,Jan Sarek +8 more
TL;DR: The pharmacological activity of naturally occurring triterpenoids excluding the degraded triter penoids and cucurbitacins is reviewed, which includes anticancer, anti-inflammatory, antiulcerogenic, antimicrobial and antiviral activity.
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Pharmacological properties of the ubiquitous natural product betulin.
TL;DR: A new mechanism of action has been confirmed for some of the most promising anti-HIV derivatives, which makes them potentially useful additives to the current anti- HIV therapy.
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Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection
TL;DR: Because of its selective cytotoxicity against tumor cells and favorable therapeutic index, even at doses up to 500 mg/kg body weight, betulinic acid is a very promising new chemotherapeutic agent for the treatment of HIV infection and cancer.
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Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy.
TL;DR: This review summarizes the potential of triterpenes belonging to the lupane, oleanane or ursane group, to treat cancer by different modes of action and utilisation of different plants as their sources is of interest.
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Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
E. Pisha,Heebyung Chai,Ik-Soo Lee,T E Chagwedera,Norman R. Farnsworth,Geoffrey A. Cordell,Chris Beecher,Harry H. S. Fong,A. D. Kinghorn,David M. Brown,David M. Brown +10 more
TL;DR: As a result of bioassay–guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma–specific cytotoxic agent and antitumour activity was mediated by the induction of apoptosis.
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Mitochondrion as a Novel Target of Anticancer Chemotherapy
TL;DR: The design of mitochondrion-targeted cytotoxic drugs may constitute a novel strategy for overcoming apoptosis resistance.
Journal Article
p53 Gene Mutations Are Associated with Decreased Sensitivity of Human Lymphoma Cells to DNA Damaging Agents
Saijun Fan,Wafik S. El-Deiry,Insoo Bae,James W. Freeman,Daniel Jondle,Kishor Bhatia,Albert J. Fornace,Ian Magrath,Kurt W. Kohn,Patrick M. O'Connor +9 more
TL;DR: The present study assessed the role of the p53 tumor suppressor gene in cell cycle arrest and apoptosis following treatment of Burkitt's lymphoma and lymphoblastoid cell lines with gamma-rays, etoposide, nitrogen mustard, and cisplatin and found that p53 mutations are often associated with decreased sensitivity to DNA damaging agents.
Journal Article
Association between Cisplatin Resistance and Mutation of p53 Gene and Reduced Bax Expression in Ovarian Carcinoma Cell Systems
Paola Perego,M. Giarola,Sabina C. Righetti,Rosanna Supino,Claudia Caserini,Domenico Delia,Marco A. Pierotti,Toshiyuki Miyashita,John C. Reed,Franco Zunino +9 more
TL;DR: Observations support a role for mutations of the p53 gene in the development of cisplatin resistance in ovarian cancer as a consequence of loss of the ability of p53 to transactivate bax, an apoptosis-inducing gene.
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Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland.
TL;DR: Results indicate that mutations of the p53 gene are associated with the most aggressive histologic types of thyroid tumors, such as the undifferentiated carcinoma and, to a certain extent, the poorly differentiated carcinoma, and that the alterations of this gene represent a late genetic event in human thyroid carcinogenesis.