Journal ArticleDOI
15N−15N J-Coupling Across HgII: Direct Observation of HgII-Mediated T−T Base Pairs in a DNA Duplex
TLDR
N−N J-coupling across a metal center (2JNN) was clearly detected in a biological macromolecule (DNA duplex) for the first time and the base pairing mode of mercury-mediated T−T pairs (T−HgII−T) was definitely determined.Abstract:
N−N J-coupling across a metal center (2JNN) was clearly detected in a biological macromolecule (DNA duplex) for the first time. By using 2JNN, the base pairing mode of mercury-mediated T−T pairs (T−HgII−T) was definitely determined. This pairing mode was found to be a novel metal ion-binding mode for DNA and RNA molecules, in which imino proton−metal exchange processes are included. Accordingly, 2JNN is highly important for the determination of the chemical structures of metal-mediated base pairs.read more
Citations
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Journal ArticleDOI
Artificial Molecular Machines
TL;DR: The latest generations of sophisticated synthetic molecular machine systems in which the controlled motion of subcomponents is used to perform complex tasks are discussed, paving the way to applications and the realization of a new era of “molecular nanotechnology”.
Journal ArticleDOI
Colorimetric Detection of Mercuric Ion (Hg2+) in Aqueous Media using DNA-Functionalized Gold Nanoparticles
TL;DR: A highly selective and sensitive colorimetric detection method for Hg that relies on thymidine–Hg–thymidine coordination chemistry and complementary DNA–Au NPs with deliberately designed T–T mismatches is presented.
Journal ArticleDOI
One-step, room temperature, colorimetric detection of mercury (Hg2+) using DNA/nanoparticle conjugates.
TL;DR: The high selectivity of this detection system is attributed to Hg2-mediated formation of T−Hg2+−T base pairs as evidenced by an increase in a sharp melting temperature.
Journal ArticleDOI
Specific interactions between silver(I) ions and cytosine–cytosine pairs in DNA duplexes
Akira Ono,Shiqi Cao,Humika Togashi,Mitsuru Tashiro,Takashi Fujimoto,Tomoya Machinami,Shuji Oda,Yoko Miyake,Itaru Okamoto,Yoshiyuki Tanaka +9 more
TL;DR: A DNA-based Ag(i) sensor was developed that employed an oligodeoxyribonucleotide containing C-C pairs used for Ag( i) binding sites that unexpectedly stabilized DNA duplexes containing the naturally occurring cytosine-cytosine (C-C) mismatch-base pair.
References
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Journal ArticleDOI
MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes
Yoko Miyake,Humika Togashi,Mitsuru Tashiro,Hiroshi Yamaguchi,Shuji Oda,Megumi Kudo,Yoshiyuki Tanaka,Yoshinori Kondo,Ryuichi Sawa,Takashi Fujimoto,Tomoya Machinami,Akira Ono +11 more
TL;DR: The very specific binding of the HgII ion unexpectedly and significantly stabilizes naturally occurring thymine-thymine base mispairing in DNA duplexes and prepared DNA dupLexes containing metal-mediated base pairs at the desired sites, as well as novel double helical architectures consisting only of thymine/HgII/thymine pairs.
Journal ArticleDOI
Direct Observation of Hydrogen Bonds in Nucleic Acid Base Pairs by Internucleotide 2JNN Couplings
TL;DR: In this article, the authors show that scalar couplings across the hydrogen bond are observable for 15N-labeled RNA for Watson−Crick base pairs in 15N labeled RNA.
Journal ArticleDOI
A discrete self-assembled metal array in artificial DNA.
TL;DR: The synthesis of a series of artificial oligonucleotides, d(5′-GH nC-3′) (n = 1 to 5), with hydroxypyridone nucleobases (H) as flat bidentate ligands is reported as a structural basis to array functionalized building blocks.
Journal ArticleDOI
Biomolecule−Mercury Interactions: Modalities of DNA Base−Mercury Binding Mechanisms. Remediation Strategies
Journal ArticleDOI
A Novel Copper-Mediated DNA Base Pair
TL;DR: A new strategy which is based on the metaldependent pairing of two nucleobases is described which would allow the replication of DNA containing novel functional groups and lead to novel polymers with interesting chemical and physical properties.
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