18F, 64Cu, and 68Ga Labeled RGD-Bombesin Heterodimeric Peptides for PET Imaging of Breast Cancer
TLDR
The prosthetic labeling groups, chelators, and isotopes all have a profound effect on the tumor targeting efficacy and in vivo kinetics of the RGD-BBN tracers for dual integrin and GRPR recognition.About:
This article is published in Bioconjugate Chemistry.The article was published on 2009-05-20 and is currently open access. It has received 135 citations till now. The article focuses on the topics: Integrin alphaVbeta3 & Gastrin-releasing peptide receptor.read more
Citations
More filters
Journal ArticleDOI
Coordinating Radiometals of Copper, Gallium, Indium, Yttrium and Zirconium for PET and SPECT Imaging of Disease
TL;DR: SPECT and PET technology has been around for decades, but its use remained limited because of the limited availability of relevant isotopes which had to be produced in nuclear reactors or particle accelerators, but the introduction of the small biomedical cyclotron, the self-contained radionuclide generator and the dedicated small animal or clinical SPECT andPET scanners to hospitals and research facilities has increased the demand for SPect and PET isotopes.
Journal ArticleDOI
Peptides and Peptide Hormones for Molecular Imaging and Disease Diagnosis
Seulki Lee,Jin Xie,Xiaoyuan Chen +2 more
TL;DR: An overview of molecular imaging probes associated with peptides and peptide hormones designed for in vivo applications, including those for nuclear imaging, optical imaging, and MRI, is provided.
Journal ArticleDOI
αVβ3 Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug
Nora Graf,Diane R. Bielenberg,Nagesh Kolishetti,Christoph Muus,Jacqueline Banyard,Omid C. Farokhzad,Stephen J. Lippard +6 more
TL;DR: The RGD-targeted PLGA-PEG NPs were more efficacious and better tolerated by comparison to cisplatin in an orthotopic human breast cancer xenograft model in vivo, and encouraged us also to evaluate the anticancer effect of the new construct in an animal model.
Journal ArticleDOI
Prospective of ⁶⁸Ga-radiopharmaceutical development.
TL;DR: The future development of the 68Ga-radiopharmaceuticals must be put in the context of several aspects such as role of PET in nuclear medicine, unmet medical needs, identification of new biomarkers, targets and corresponding ligands, production and availability of 68Ga, automation of the radiopharm pharmaceutical production, progress of positron emission tomography technologies and image analysis methodologies.
Journal ArticleDOI
Biomedical applications of macrocyclic ligand complexes
TL;DR: The use of such complexes in imaging as MRI contrast agents, radiopharmaceuticals and luminescent probes is discussed, and the considerable scope for future development of novel metal based therapeutics based on protein binding, targeting of radioisotopes or dual function agents is highlighted.
References
More filters
Journal ArticleDOI
Integrins: Bidirectional, Allosteric Signaling Machines
TL;DR: Current structural and cell biological data suggest models for how integrins transmit signals between their extracellular ligand binding adhesion sites and their cytoplasmic domains, which link to the cytoskeleton and to signal transduction pathways.
Journal ArticleDOI
Cancer statistics, 2001.
TL;DR: Estimates of the number of new cancer cases and deaths expected in the US in the current year and the most recent data on cancer incidence, mortality, and survival reveal large disparities in cancer incidence and mortality across racial/ethnic groups.
Journal ArticleDOI
Requirement of vascular integrin alpha v beta 3 for angiogenesis
TL;DR: The adhesion receptor integrin alpha v beta 3 was identified as a marker of angiogenic vascular tissue in this paper, and it showed a fourfold increase in expression during angiogenesis on the chick chorioallantoic membrane.
Journal ArticleDOI
Breast cancer metastasis: markers and models
TL;DR: New molecular technologies, such as DNA microarrays, support the idea that metastatic capacity might be an inherent feature of breast tumours and have important implications for prognosis predicition and the understanding of metastasis.
Journal ArticleDOI
Role of integrins in cell invasion and migration
John Hood,David A. Cheresh +1 more
TL;DR: As cancer cells undergo metastasis — invasion and migration of a new tissue — they penetrate and attach to the target tissue's basal matrix, which allows the cancer cell to pull itself forward into the tissue.
Related Papers (5)
68Ga-labeled multimeric RGD peptides for microPET imaging of integrin αvβ3 expression
Zibo Li,Kai Chen,Xiaoyuan Chen +2 more