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Christoph Muus

Researcher at Broad Institute

Publications -  24
Citations -  4043

Christoph Muus is an academic researcher from Broad Institute. The author has contributed to research in topics: Mitochondrial DNA & Chromatin. The author has an hindex of 16, co-authored 18 publications receiving 2422 citations. Previous affiliations of Christoph Muus include Heidelberg University & Harvard University.

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Journal ArticleDOI

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.

Carly G. K. Ziegler, +135 more
- 28 May 2020 - 
TL;DR: The data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection.
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COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.

Toni Delorey, +137 more
- 29 Apr 2021 - 
TL;DR: In this article, single-cell analysis of lung, heart, kidney and liver autopsy samples shows the molecular and cellular changes and immune response resulting from severe SARS-CoV-2 infection.
Journal ArticleDOI

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics.

Leif S. Ludwig, +24 more
- 07 Mar 2019 - 
TL;DR: This work shows that somatic mutations in mtDNA can be tracked by single-cell RNA or assay for transposase accessible chromatin (ATAC) sequencing and leverages somatic mtDNA mutations as natural genetic barcodes and demonstrates their utility as highly accurate clonal markers to infer cellular relationships.
Journal ArticleDOI

αVβ3 Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug

Nora Graf, +6 more
- 14 May 2012 - 
TL;DR: The RGD-targeted PLGA-PEG NPs were more efficacious and better tolerated by comparison to cisplatin in an orthotopic human breast cancer xenograft model in vivo, and encouraged us also to evaluate the anticancer effect of the new construct in an animal model.
Posted ContentDOI

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

Pascal Barbry, +113 more
- 20 Apr 2020 - 
TL;DR: Differences in the cell type-specific expression of mediators of SARS-CoV-2 viral entry may be responsible for aspects of COVID-19 epidemiology and clinical course, and point to putative molecular pathways involved in disease susceptibility and pathogenesis.