Journal ArticleDOI
3D cell printing of in vitro stabilized skin model and in vivo pre-vascularized skin patch using tissue-specific extracellular matrix bioink: A step towards advanced skin tissue engineering
Byoung Soo Kim,Yang Woo Kwon,Jeong-Sik Kong,Gyu Tae Park,Ge Gao,Wonil Han,Moon-Bum Kim,Hyungseok Lee,Jae Ho Kim,Dong-Woo Cho +9 more
TLDR
This study investigated the capability of skin-derived extracellular matrix (S-dECM) bioink for 3D cell printing-based skin tissue engineering and used this bioink to print 3D pre-vascularized skin patch able to promote in vivo wound healing and revealed that endothelial progenitor cells-laden 3D-printed skin patch accelerates wound closure, re-epithelization, and neovascularization as well as blood flow.About:
This article is published in Biomaterials.The article was published on 2018-06-01. It has received 319 citations till now. The article focuses on the topics: Skin patch & Human skin.read more
Citations
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Journal ArticleDOI
Functional Hydrogels as Wound Dressing to Enhance Wound Healing.
TL;DR: In this paper, a comprehensive review of the functional hydrogel as a wound dressing is presented, which summarizes the skin wound healing process and relates evaluation parameters and then reviews the advanced functions of hydrogels such as antimicrobial property, adhesion and hemostasis, anti-inflammatory and anti-oxidation, substance delivery, self-healing, stimulus response, conductivity, and the recently emerged wound monitoring feature.
Journal ArticleDOI
3D and 4D Printing of Polymers for Tissue Engineering Applications.
Dilara Goksu Tamay,Tugba Dursun Usal,Ayse Selcen Alagoz,Deniz Yucel,Nesrin Hasirci,Vasif Hasirci +5 more
TL;DR: 3D and 4D printing techniques have great potential in the production of scaffolds to be applied in tissue engineering, especially in constructing patient specific scaffolds, and physical and chemical guidance cues can be printed with these methods to improve the extent and rate of targeted tissue regeneration.
Journal ArticleDOI
From Shape to Function: The Next Step in Bioprinting
TL;DR: The recent material and technological advances since the introduction of the biofabrication window are briefly summarized, i.e., approaches how to generate shape, to then focus the discussion on how to acquire the biological function within this context.
Journal ArticleDOI
The bioprinting roadmap
Wei Sun,Wei Sun,Binil Starly,Andrew C. Daly,Jason A. Burdick,Juergen Groll,Gregor Skeldon,Gregor Skeldon,Wenmiao Shu,Yasuyuki Sakai,Marie Shinohara,Masaki Nishikawa,Jinah Jang,Dong-Woo Cho,Minghao Nie,Shoji Takeuchi,Serge Ostrovidov,Ali Khademhosseini,Roger D. Kamm,Vladimir Mironov,Lorenzo Moroni,Ibrahim T. Ozbolat +21 more
TL;DR: This bioprinting roadmap features salient advances in selected applications of the technique and highlights the status of current developments and challenges, as well as envisioned advances in science and technology, to address the challenges to the young and evolving technique.
Journal ArticleDOI
Print me an organ! Why we are not there yet
TL;DR: An in-depth analysis of recent improvements in the bioprinting techniques, progress in bio-ink development, implementation of new biopprinting and tissue maturation strategies, and the role of polymer science is presented.
References
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Journal ArticleDOI
3D bioprinting of tissues and organs
Sean V. Murphy,Anthony Atala +1 more
TL;DR: 3D bioprinting is being applied to regenerative medicine to address the need for tissues and organs suitable for transplantation and developing high-throughput 3D-bioprinted tissue models for research, drug discovery and toxicology.
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Wound Healing--Aiming for Perfect Skin Regeneration
TL;DR: Details of how these signals control wound cell activities are beginning to emerge, and studies of healing in embryos have begun to show how the normal adult repair process might be readjusted to make it less like patching up and more like regeneration.
Journal ArticleDOI
Bone Marrow Origin of Endothelial Progenitor Cells Responsible for Postnatal Vasculogenesis in Physiological and Pathological Neovascularization
Takayuki Asahara,Haruchika Masuda,Tomono Takahashi,Christoph Kalka,Christopher Pastore,Marcy Silver,Marianne Kearne,Meredith Magner,Jeffrey M. Isner +8 more
TL;DR: Findings indicate that postnatal neovascularization does not rely exclusively on sprouting from preexisting blood vessels (angiogenesis); instead, EPCs circulate from bone marrow to incorporate into and thus contribute to postnatal physiological and pathological neov vascularization, which is consistent with postnatal vasculogenesis.
Journal ArticleDOI
Proliferation, cell cycle and apoptosis in cancer
Gerard I. Evan,Karen H. Vousden +1 more
TL;DR: Deregulated cell proliferation provides a minimal 'platform' necessary to support further neoplastic progression and should be targeted withroit targeting to have potent and specific therapeutic consequences.
Journal ArticleDOI
Nonmyeloablative Stem Cell Transplantation and Cell Therapy as an Alternative to Conventional Bone Marrow Transplantation With Lethal Cytoreduction for the Treatment of Malignant and Nonmalignant Hematologic Diseases
Shimon Slavin,Arnon Nagler,Ella Naparstek,Yossi Kapelushnik,Memet Aker,Gabriel Cividalli,G. Varadi,Mark Kirschbaum,Aliza Ackerstein,Simcha Samuel,Avraham Amar,Chaim Brautbar,Ofira Ben-Tal,Amiram Eldor,Reuven Or +14 more
TL;DR: Preliminary data in 26 patients with standard indications for allogeneic BMT suggest that nonmyeloablative conditioning including fludarabine, anti-T-lymphocyte globulin, and low-dose busulfan is extremely well tolerated, with no severe procedure-related toxicity.