Journal ArticleDOI
8-Hydroxyquinolines in medicinal chemistry: A structural perspective.
TLDR
This review has summarized 8-Hydroxyquinolines, 8-hydroxyquinoline-like compounds,8-hydrox Quinoline-loaded nanoparticle systems with respect to their biological activities, interaction with metal ions and mechanisms of action.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2016-09-14. It has received 198 citations till now. The article focuses on the topics: Hydroxyquinolines.read more
Citations
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Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents that Target and Modulate Multiple Facets of Alzheimer’s Disease
Jeffrey S. Derrick,Mi Hee Lim +1 more
TL;DR: In this paper, a novel compound (ML) prototype of a rationally designed molecule obtained by integrating structural elements for Aβ aggregation control, metal chelation, reactive oxygen species (ROS) regulation, and antioxidant activity within a single molecule.
Journal ArticleDOI
An overview of quinoline as a privileged scaffold in cancer drug discovery
TL;DR: The quinoline moiety offers an easily accessible, well-understood scaffold for designing new drugs, and is also a very druggable molecule with the potency for structure optimization through established synthetic pathways, which has a strong position in modern medicinal chemistry.
Journal ArticleDOI
Radiolabelling of nanomaterials for medical imaging and therapy.
TL;DR: In this paper, the authors present a review of the most relevant and up-to-date knowledge available in this field, and support the efficient clinical translation of future nanomedicinal products for in vivo imaging and/or therapy.
Journal ArticleDOI
Nuclear imaging of liposomal drug delivery systems: A critical review of radiolabelling methods and applications in nanomedicine.
TL;DR: The need for knowing the biodistribution/pharmacokinetics of both the radiolabelled liposomal components and free radionuclides in order to confidently evaluate the images is stressed, as they often share excretion pathways with intact liposomes and even show significant tumour uptake by themselves.
Journal ArticleDOI
Novel mitochondria targeted copper(II) complexes of ferrocenyl terpyridine and anticancer active 8-hydroxyquinolines showing remarkable cytotoxicity, DNA and protein binding affinity
Banashree Deka,Tukki Sarkar,Samya Banerjee,Arun Kumar,Sanjoy Mukherjee,Sasanka Deka,Kandarpa Kumar Saikia,Akhtar Hussain +7 more
TL;DR: This work is the first report to show that the ferrocenyl appended copper(ii) complexes of hydroxyquinoline ligands are remarkably cytotoxic to cancer cells but significantly less toxic to normal cells.
References
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Book
Critical Stability Constants
TL;DR: Erratum to: Aminocarboxylic Acids to: Iminodiacetic Acid Derivatives to: Peptides to: Aliphatic Amines to: Protonation Values for other Ligands.
Journal ArticleDOI
Iron, brain ageing and neurodegenerative disorders
TL;DR: By studying the accumulation and cellular distribution of iron during ageing, this work should be able to increase the understanding of these neurodegenerative disorders and develop new therapeutic strategies.
Journal ArticleDOI
Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice
Robert A. Cherny,Craig S. Atwood,Michel Xilinas,Danielle N. Gray,Walton D. Jones,Catriona McLean,Kevin J. Barnham,Irene Volitakis,Fiona W. Fraser,Young-Seon Kim,Xudong Huang,Lee E. Goldstein,Robert D. Moir,James Lim,Konrad Beyreuther,Hui Zheng,Rudolph E. Tanzi,Colin L. Masters,Ashley I. Bush,Ashley I. Bush +19 more
TL;DR: A 49% decrease in brain Abeta deposition is reported in a blinded study of APP2576 transgenic mice treated orally for 9 weeks with clioquinol, an antibiotic and bioavailable Cu/Zn chelator, support targeting the interactions of Cu and Zn with Abeta as a novel therapy for the prevention and treatment of AD.
Journal ArticleDOI
Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease: A Pilot Phase 2 Clinical Trial
Craig W. Ritchie,Ashley I. Bush,Andrew Mackinnon,Steve Macfarlane,Maree Mastwyk,Lachlan MacGregor,Lyn Kiers,Robert A. Cherny,Qiao-Xin Li,Amanda Tammer,Darryl Carrington,Christine Mavros,Irene Volitakis,Michel Xilinas,David Ames,Stephen M. Davis,Konrad Beyreuther,Rudolph E. Tanzi,Colin L. Masters +18 more
TL;DR: This pilot phase 2 study supports further investigation of this novel treatment strategy using a metal-protein-attenuating compound, and the effect of treatment was significant in the more severely affected group.
Journal ArticleDOI
Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ
Paul A. Adlard,Robert A. Cherny,Robert A. Cherny,David Finkelstein,David Finkelstein,Elisabeth Gautier,Elysia Robb,Mikhalina Cortes,Irene Volitakis,Xiang Liu,Jeffrey P. Smith,Keyla Perez,Keyla Perez,Katrina M. Laughton,Katrina M. Laughton,Qiao-Xin Li,Qiao-Xin Li,Susan A. Charman,Joseph A. Nicolazzo,Simon Wilkins,Simon Wilkins,Karolina Deleva,Toni Lynch,Gaik Beng Kok,Craig W. Ritchie,Rudolph E. Tanzi,Roberto Cappai,Roberto Cappai,Colin L. Masters,Colin L. Masters,Kevin J. Barnham,Kevin J. Barnham,Ashley I. Bush,Ashley I. Bush +33 more
TL;DR: The current data demonstrate that ionophore activity, inhibition of in vitro metal-mediated Abeta reactions, and blood-brain barrier permeability are indices that predict a potential disease-modifying drug for AD.