8-Oxoguanine DNA glycosylase1–driven DNA repair—A paradoxical role in lung aging
Peter German,David Saenz,Peter Szaniszlo,Leopoldo Aguilera-Aguirre,Lang Pan,Muralidhar L. Hegde,Attila Bacsi,Gyorgy Hajas,Zsolt Radak,Xueqing Ba,Sankar Mitra,John Papaconstantinou,Istvan Boldogh +12 more
TLDR
Gene ontology analysis of gene expression displayed biological processes driven by small GTPases, phosphoinositide 3-kinase and mitogen activated kinase cascades both in cultured cells and lungs, which points to a new paradigm about the role of DNA damage and repair by OGG1 in aging and age-associated disease processes.About:
This article is published in Mechanisms of Ageing and Development.The article was published on 2017-01-01 and is currently open access. It has received 13 citations till now. The article focuses on the topics: Senescence & DNA repair.read more
Citations
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Oxidatively generated base modifications in DNA: Not only carcinogenic risk factor but also regulatory mark? ☆
Marco Seifermann,Bernd Epe +1 more
TL;DR: The activation of transcription by the estrogen receptor, NF-κB, MYC and other transcription factors was shown to depend on the presence of 8-oxoG in the promoter regions and its recognition by the DNA repair glycosylase OGG1, which was demonstrated to act as a guanine nucleotide exchange factor (GEF) for small GTPases such as Ras, Rac and Rho, thus stimulating signal transduction.
Journal ArticleDOI
Unveiling the non-repair face of the Base Excision Repair pathway in RNA processing: A missing link between DNA repair and gene expression?
TL;DR: Surprisingly, BER pathway involvement in transcriptional regulation, immunoglobulin variability and switch recombination, RNA metabolism and nucleolar function is astonishingly consolidating, proving a substantial role of the interactome network in determining their non-canonical functions in tumor cells.
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The roles of base excision repair enzyme OGG1 in gene expression
TL;DR: How cells exploit damaged guanine base(s) and the authentic repair protein to orchestrate a profile of various transcriptomes in redox-regulated biological processes is discussed.
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OGG1-DNA interactions facilitate NF-κB binding to DNA targets
TL;DR: It is shown that DNA occupancy of NF-κB present in nuclear extracts from tumour necrosis factor alpha exposed cells is OGG1 and 8-oxoG position dependent, importantly, O GG1 counteracting 8-OxoG outside consensus motif had a profound influence on purified NF-σκB binding to DNA.
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A deep dive into UV-based phototherapy: Mechanisms of action and emerging molecular targets in inflammation and cancer.
TL;DR: UV-based phototherapy has a long, successful history in the management of numerous cutaneous disorders and its key effects-proapoptotic, immunomodulatory, antipruritic, antifibrotic, propigmentary, and pro-prebiotic-promote clinical improvement in various skin diseases.
References
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The serial cultivation of human diploid cell strains.
Leonard Hayflick,P.S. Moorhead +1 more
TL;DR: A consideration of the cause of the eventual degeneration of these strains leads to the hypothesis that non-cumulative external factors are excluded and that the phenomenon is attributable to intrinsic factors which are expressed as senescence at the cellular level.
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A biomarker that identifies senescent human cells in culture and in aging skin in vivo
Goberdhan P. Dimri,X Lee,G Basile,Meileen Acosta,G Scott,C Roskelley,E E Medrano,Maarten H.K. Linskens,Ivica Rubelj,Olivia M. Pereira-Smith +9 more
TL;DR: It is shown that several human cells express a beta-galactosidase, histochemically detectable at pH 6, upon senescence in culture, which provides in situ evidence that senescent cells may exist and accumulate with age in vivo.
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The DNA-damage response in human biology and disease
Stephen P. Jackson,Jiri Bartek +1 more
TL;DR: The authors' improving understanding of DNA-damage responses is providing new avenues for disease management, and these responses are biologically significant because they prevent diverse human diseases.
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Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
TL;DR: It is shown that expression of oncogenic ras in primary human or rodent cells results in a permanent G1 arrest, and that the onset of cellular senescence does not simply reflect the accumulation of cell divisions, but can be prematurely activated in response to an onCogenic stimulus.
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The Free Radical Theory of Aging Matures
Kenneth B. Beckman,Bruce N. Ames +1 more
TL;DR: The status of the free radical theory of aging is reviewed, by categorizing the literature in terms of the various types of experiments that have been performed, which include phenomenological measurements of age-associated oxidative stress, interspecies comparisons, dietary restriction, and the ongoing elucidation of the role of active oxygen in biology.