A critical review: vitamin b deficiency and nervous disease.
C. D. Aring,Tom Douglas Spies +1 more
TLDR
The artificial synthesis of a number of the components of the vitamin B complex has made available pure crystalline material in large amounts for clinical research, and thus a milestone in the history of these affections has been passed.Abstract:
AFFECTIONS of the nervous system which result from inadequate nutrition have assumed an increasingly important position through the rapid accumulation of clinical, experimental, and pathological data. The artificial synthesis of a number of the components of the vitamin B complex has made available pure crystalline material in large amounts for clinical research, and thus a milestone in the history of these affections has been passed. It now seems appropriate to review and summarize the knowledge of these important substances. To evaluate the status of a nutritional deficiency in man is difficult. As a rule the patient induces his own disease and provides a deficiency that is not quantitatively measurable, but frequently clinical and laboratory evaluations are attempted. Both the laboratory method and the clinical method have certain advantages. Mice are not yet men and until they are the work coming -from the study of human beings is essential. Since the experience of investigators working with animals may often point the way for clinical research, we have interspersed in this review a few of the pertinent studies on the effect of nutritional deficiency on the nervous system of animals. A scheme for illustrating the multiple factors of the vitamin B complex is given in Fig. 1. To date the following portions of the vitamin B complex have been isolated and synthesized in amounts sufficient to allow for clinical trial: thiamin hydrochloride, nicotinic acid, riboflavin, and 2-methyl, 3-hydroxy, 4, 5-di (hydroxymethyl) pyridine. The deficiencies of these substances as they apply to the nervous system of man will be discussed briefly.read more
Citations
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Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins
Bernd Wollscheid,Damaris Bausch-Fluck,Damaris Bausch-Fluck,Christine Henderson,Robert V. O’Brien,Miriam Bibel,Ralph Schiess,Ruedi Aebersold,Ruedi Aebersold,Julian D. Watts +9 more
TL;DR: A snapshot view of the cell surface N- glycoproteins will enable detection of panels of N-glycoprotein as potential differentiation markers that are currently not accessible by other means.
Supplementary Materials for Low Mid-Proterozoic atmospheric oxygen levels and the delayed rise of animals
Noah J. Planavsky,Christopher T. Reinhard,Xiangli Wang,Danielle Thomson,Robert H. Rainbird,Thomas M. Johnson,Woodward W. Fischer,W Timothy +7 more
TL;DR: Evidence for inhibited oxidation of Cr at Earth’s surface in the mid-Proterozoic is found, suggesting that atmospheric O2 levels were at most 0.1% of present atmospheric levels.
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Biodegradable and flexible arterial-pulse sensor for the wireless monitoring of blood flow
Clementine M. Boutry,Levent Beker,Yukitoshi Kaizawa,Christopher Vassos,Helen Tran,Allison C. Hinckley,Raphael Pfattner,Simiao Niu,Junheng Li,Jean Claverie,Zhen Wang,Zhen Wang,James Chang,James Chang,Paige M. Fox,Paige M. Fox,Zhenan Bao +16 more
TL;DR: A battery-free implantable pressure sensor made entirely of biodegradable materials and based on fringe-field capacitor technology can wirelessly measure arterial blood flow in live rats and may be advantageous in real-time post-operative monitoring of blood flow after reconstructive surgery.
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Extracellular matrix-based materials for regenerative medicine
TL;DR: Challenges and opportunities of ECM biomaterials are investigated for the design of organotypic models to study disease progression, for the ex vivo creation of engineered tissue and for the clinical translation of functional tissue reconstruction strategies in vivo.
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Organic–inorganic interactions in petroleum-producing sedimentary basins
TL;DR: These findings suggest that petroleum generation and stability is influenced by subsurface chemical environments, and is a simple function of time, temperature and the composition of sedimentary organic matter.
References
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Journal ArticleDOI
The peripheral nerves in cases of subacute combined degeneration of the cord
Journal ArticleDOI
Effect of chronic vitamin e deficiency in the nervous system and the skeletal musculature in adult rats
Einarso n,Ringste d +1 more
Effect of Chronic Vitamin E Deficiency on the Nervous System and the Skeletal Musculature in Adult Rats.
L. Einarson,A. Ringsted +1 more
Journal ArticleDOI
The Selective Hydrogenation of Unsaturated Esters to Unsaturated Alcohols
J. C. Sauer,Homer Adkins +1 more
Journal ArticleDOI
Relationship between nicotinic acid and a codehydrogenase (cozymase): in blood of pellagrins and normal persons
TL;DR: Extensive treatment of several hundred pellagrins with nicotinic acid has shown that B. influenzae can be used to measure accurately the cozymase content of the blood in normal persons and in pellAGrins.