A critical review: vitamin b deficiency and nervous disease.
C. D. Aring,Tom Douglas Spies +1 more
TLDR
The artificial synthesis of a number of the components of the vitamin B complex has made available pure crystalline material in large amounts for clinical research, and thus a milestone in the history of these affections has been passed.Abstract:
AFFECTIONS of the nervous system which result from inadequate nutrition have assumed an increasingly important position through the rapid accumulation of clinical, experimental, and pathological data. The artificial synthesis of a number of the components of the vitamin B complex has made available pure crystalline material in large amounts for clinical research, and thus a milestone in the history of these affections has been passed. It now seems appropriate to review and summarize the knowledge of these important substances. To evaluate the status of a nutritional deficiency in man is difficult. As a rule the patient induces his own disease and provides a deficiency that is not quantitatively measurable, but frequently clinical and laboratory evaluations are attempted. Both the laboratory method and the clinical method have certain advantages. Mice are not yet men and until they are the work coming -from the study of human beings is essential. Since the experience of investigators working with animals may often point the way for clinical research, we have interspersed in this review a few of the pertinent studies on the effect of nutritional deficiency on the nervous system of animals. A scheme for illustrating the multiple factors of the vitamin B complex is given in Fig. 1. To date the following portions of the vitamin B complex have been isolated and synthesized in amounts sufficient to allow for clinical trial: thiamin hydrochloride, nicotinic acid, riboflavin, and 2-methyl, 3-hydroxy, 4, 5-di (hydroxymethyl) pyridine. The deficiencies of these substances as they apply to the nervous system of man will be discussed briefly.read more
Citations
More filters
Journal ArticleDOI
Ecological scaffolding and the evolution of individuality.
TL;DR: Using mechanistic mathematical models, it is shown how a minimal ecological structure comprising patchily distributed resources and between-patch dispersal can scaffold Darwinian-like properties on collectives of cells and serves as an ecological recipe for experimental realization of evolutionary transitions.
Book ChapterDOI
State and Transition Models: Theory, Applications, and Challenges
Brandon T. Bestelmeyer,Andrew Ash,Joel R. Brown,Bulgamaa Densambuu,María E. Fernández-Giménez,Jamin K. Johanson,Matthew R. Levi,Dardo Ruben Lopez,Raul Peinetti,Libby Rumpff,Patrick L. Shaver +10 more
TL;DR: This chapter provides a comprehensive and contemporary overview of STMs concepts and applications at a global level, and provides a synthesis of the history of STM development and current applications in rangelands of Australia, Argentina, the United States, and Mongolia.
Journal ArticleDOI
Social inappropriateness in neurodegenerative disorders.
TL;DR: Through various manifestations, social inappropriateness is frequently the first clinical sign of a neurodegenerative process, especially in AD and bvFTD, years before noticeable impairment on classical neuropsychological assessment and brain atrophy on imaging.
Journal ArticleDOI
Removal of anionic dye Congo red from aqueous environment using polyvinyl alcohol/sodium alginate/ZSM-5 zeolite membrane.
TL;DR: Experimental studies suggest that PVA/SA/ZSM-5 zeolite could be a promising candidate for the removal of Congo red from aqueous solution.
References
More filters
Journal ArticleDOI
The peripheral nerves in cases of subacute combined degeneration of the cord
Journal ArticleDOI
Effect of chronic vitamin e deficiency in the nervous system and the skeletal musculature in adult rats
Einarso n,Ringste d +1 more
Effect of Chronic Vitamin E Deficiency on the Nervous System and the Skeletal Musculature in Adult Rats.
L. Einarson,A. Ringsted +1 more
Journal ArticleDOI
The Selective Hydrogenation of Unsaturated Esters to Unsaturated Alcohols
J. C. Sauer,Homer Adkins +1 more
Journal ArticleDOI
Relationship between nicotinic acid and a codehydrogenase (cozymase): in blood of pellagrins and normal persons
TL;DR: Extensive treatment of several hundred pellagrins with nicotinic acid has shown that B. influenzae can be used to measure accurately the cozymase content of the blood in normal persons and in pellAGrins.