A critical review: vitamin b deficiency and nervous disease.
C. D. Aring,Tom Douglas Spies +1 more
TLDR
The artificial synthesis of a number of the components of the vitamin B complex has made available pure crystalline material in large amounts for clinical research, and thus a milestone in the history of these affections has been passed.Abstract:
AFFECTIONS of the nervous system which result from inadequate nutrition have assumed an increasingly important position through the rapid accumulation of clinical, experimental, and pathological data. The artificial synthesis of a number of the components of the vitamin B complex has made available pure crystalline material in large amounts for clinical research, and thus a milestone in the history of these affections has been passed. It now seems appropriate to review and summarize the knowledge of these important substances. To evaluate the status of a nutritional deficiency in man is difficult. As a rule the patient induces his own disease and provides a deficiency that is not quantitatively measurable, but frequently clinical and laboratory evaluations are attempted. Both the laboratory method and the clinical method have certain advantages. Mice are not yet men and until they are the work coming -from the study of human beings is essential. Since the experience of investigators working with animals may often point the way for clinical research, we have interspersed in this review a few of the pertinent studies on the effect of nutritional deficiency on the nervous system of animals. A scheme for illustrating the multiple factors of the vitamin B complex is given in Fig. 1. To date the following portions of the vitamin B complex have been isolated and synthesized in amounts sufficient to allow for clinical trial: thiamin hydrochloride, nicotinic acid, riboflavin, and 2-methyl, 3-hydroxy, 4, 5-di (hydroxymethyl) pyridine. The deficiencies of these substances as they apply to the nervous system of man will be discussed briefly.read more
Citations
More filters
Journal ArticleDOI
Predictors of stroke outcome using objective measurement scales.
S C Loewen,B A Anderson +1 more
TL;DR: It is suggested that the Modified Motor Assessment Scale and the Barthel Index be used as adjuncts in prioritizing and directing the rehabilitation management of patients with stroke.
Journal ArticleDOI
Highly efficient electrosynthesis of hydrogen peroxide on a superhydrophobic three-phase interface by natural air diffusion
TL;DR: Long-term operation stability of NADE and its high current efficiency under high current density indicate great potential to replace normal GDE for H 2 O 2 electrosynthesis and environmental remediation on an industrial scale.
Journal ArticleDOI
An Introductory Review of Deep Learning for Prediction Models With Big Data
TL;DR: This paper presents an introductory review of deep learning approaches including Deep Feedforward Neural Networks (D-FFNN), Convolutional Neural networks (CNNs), Deep Belief Networks (DBNs), Autoencoders (AEs), and Long Short-Term Memory (LSTM) networks.
Journal ArticleDOI
Aspirin for the prevention of cardiovascular events in patients with peripheral artery disease: a meta-analysis of randomized trials.
TL;DR: In patients with PAD, treatment with aspirin alone or with dipyridamole resulted in a statistically nonsignificant decrease in the primary end point of cardiovascular events and a significant reduction in nonfatal stroke.
Journal ArticleDOI
Heat stress causes substantial labour productivity loss in Australia
TL;DR: The authors found that climate change is expected to exacerbate absenteeism as a result of heat stress, with ramifications for labour productivity, leading to an economic burden of around US$6.2 billion.
References
More filters
Journal ArticleDOI
The peripheral nerves in cases of subacute combined degeneration of the cord
Journal ArticleDOI
Effect of chronic vitamin e deficiency in the nervous system and the skeletal musculature in adult rats
Einarso n,Ringste d +1 more
Effect of Chronic Vitamin E Deficiency on the Nervous System and the Skeletal Musculature in Adult Rats.
L. Einarson,A. Ringsted +1 more
Journal ArticleDOI
The Selective Hydrogenation of Unsaturated Esters to Unsaturated Alcohols
J. C. Sauer,Homer Adkins +1 more
Journal ArticleDOI
Relationship between nicotinic acid and a codehydrogenase (cozymase): in blood of pellagrins and normal persons
TL;DR: Extensive treatment of several hundred pellagrins with nicotinic acid has shown that B. influenzae can be used to measure accurately the cozymase content of the blood in normal persons and in pellAGrins.