A critical review: vitamin b deficiency and nervous disease.
C. D. Aring,Tom Douglas Spies +1 more
TLDR
The artificial synthesis of a number of the components of the vitamin B complex has made available pure crystalline material in large amounts for clinical research, and thus a milestone in the history of these affections has been passed.Abstract:
AFFECTIONS of the nervous system which result from inadequate nutrition have assumed an increasingly important position through the rapid accumulation of clinical, experimental, and pathological data. The artificial synthesis of a number of the components of the vitamin B complex has made available pure crystalline material in large amounts for clinical research, and thus a milestone in the history of these affections has been passed. It now seems appropriate to review and summarize the knowledge of these important substances. To evaluate the status of a nutritional deficiency in man is difficult. As a rule the patient induces his own disease and provides a deficiency that is not quantitatively measurable, but frequently clinical and laboratory evaluations are attempted. Both the laboratory method and the clinical method have certain advantages. Mice are not yet men and until they are the work coming -from the study of human beings is essential. Since the experience of investigators working with animals may often point the way for clinical research, we have interspersed in this review a few of the pertinent studies on the effect of nutritional deficiency on the nervous system of animals. A scheme for illustrating the multiple factors of the vitamin B complex is given in Fig. 1. To date the following portions of the vitamin B complex have been isolated and synthesized in amounts sufficient to allow for clinical trial: thiamin hydrochloride, nicotinic acid, riboflavin, and 2-methyl, 3-hydroxy, 4, 5-di (hydroxymethyl) pyridine. The deficiencies of these substances as they apply to the nervous system of man will be discussed briefly.read more
Citations
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Diagnostic Challenge and Neuromuscular Junction Contribution to ALS Pathogenesis
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Antidepressants self-poisoning and ICU admissions in a university hospital in The Netherlands.
Tessa M. Bosch,Tjip S. van der Werf,Donald R. A. Uges,Jack J. M. Ligtenberg,J W Fijen,Jaap E. Tulleken,Jan G. Zijlstra +6 more
TL;DR: The data from this ICU-population confirm previous evidence that SSRIs are safer in overdose than TCAs, and Physicians should be more reluctant in prescribing TCAs to depressed patients in whom the risk of self-poisoning is difficult to assess.
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Losing half the conductive area hardly impacts the water status of mature trees
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Alternative methods for the replacement of eye irritation testing.
Christian Lotz,Freia F. Schmid,Angela Rossi,Szymon Kurdyn,Daniel Kampik,Bart De Wever,Heike Walles,Florian Groeber +7 more
TL;DR: This review summarizes the progress of alternative test methods for the assessment of eye irritation and highlights emerging, full thickness cornea models that might be applicable to predict all GHS categories.
References
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Journal ArticleDOI
The peripheral nerves in cases of subacute combined degeneration of the cord
Journal ArticleDOI
Effect of chronic vitamin e deficiency in the nervous system and the skeletal musculature in adult rats
Einarso n,Ringste d +1 more
Effect of Chronic Vitamin E Deficiency on the Nervous System and the Skeletal Musculature in Adult Rats.
L. Einarson,A. Ringsted +1 more
Journal ArticleDOI
The Selective Hydrogenation of Unsaturated Esters to Unsaturated Alcohols
J. C. Sauer,Homer Adkins +1 more
Journal ArticleDOI
Relationship between nicotinic acid and a codehydrogenase (cozymase): in blood of pellagrins and normal persons
TL;DR: Extensive treatment of several hundred pellagrins with nicotinic acid has shown that B. influenzae can be used to measure accurately the cozymase content of the blood in normal persons and in pellAGrins.