A critical review: vitamin b deficiency and nervous disease.
C. D. Aring,Tom Douglas Spies +1 more
TLDR
The artificial synthesis of a number of the components of the vitamin B complex has made available pure crystalline material in large amounts for clinical research, and thus a milestone in the history of these affections has been passed.Abstract:
AFFECTIONS of the nervous system which result from inadequate nutrition have assumed an increasingly important position through the rapid accumulation of clinical, experimental, and pathological data. The artificial synthesis of a number of the components of the vitamin B complex has made available pure crystalline material in large amounts for clinical research, and thus a milestone in the history of these affections has been passed. It now seems appropriate to review and summarize the knowledge of these important substances. To evaluate the status of a nutritional deficiency in man is difficult. As a rule the patient induces his own disease and provides a deficiency that is not quantitatively measurable, but frequently clinical and laboratory evaluations are attempted. Both the laboratory method and the clinical method have certain advantages. Mice are not yet men and until they are the work coming -from the study of human beings is essential. Since the experience of investigators working with animals may often point the way for clinical research, we have interspersed in this review a few of the pertinent studies on the effect of nutritional deficiency on the nervous system of animals. A scheme for illustrating the multiple factors of the vitamin B complex is given in Fig. 1. To date the following portions of the vitamin B complex have been isolated and synthesized in amounts sufficient to allow for clinical trial: thiamin hydrochloride, nicotinic acid, riboflavin, and 2-methyl, 3-hydroxy, 4, 5-di (hydroxymethyl) pyridine. The deficiencies of these substances as they apply to the nervous system of man will be discussed briefly.read more
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An Examination of the Gender Inclusiveness of Current Theories of Sexual Violence in Adulthood: Recognizing Male Victims, Female Perpetrators, and Same-Sex Violence
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AhR, ARNT, and CYP1A1 mRNA quantitation in cultured human embryonic palates exposed to TCDD and comparison with mouse palate in vivo and in culture.
TL;DR: It seems highly unlikely that human embryos could be exposed to sufficient TCDD to achieve changes in palatal differentiation that would lead to cleft palate, but a high correlation across species for the induction of CYP1A1 was shown.
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A surface-stabilized ozonide triggers bromide oxidation at the aqueous solution-vapour interface
Luca Artiglia,Jacinta Edebeli,Jacinta Edebeli,Fabrizio Orlando,Shuzhen Chen,Shuzhen Chen,Ming-Tao Lee,Ming-Tao Lee,Pablo Corral Arroyo,Pablo Corral Arroyo,Anina Gilgen,Anina Gilgen,Thorsten Bartels-Rausch,Armin Kleibert,Mario Vazdar,Marcelo A. Carignano,Joseph S. Francisco,Paul B. Shepson,Ivan Gladich,Markus Ammann +19 more
TL;DR: Spectroscopic, kinetic and theoretical evidence is provided for a rate limiting, surface active ozonide formed at the interface, providing a strong case of different reaction kinetics and mechanisms of reactions occurring at the aqueous phase-vapour interface compared with the bulk aQueous phase.
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Does age predict outcome in stroke rehabilitation? A study of 878 Chinese subjects.
TL;DR: Admission functional status, employment and living at home before stroke but not age per se are predictors of a good outcome following stroke rehabilitation, as older patients show comparable improvement during rehabilitation, intensive rehabilitation should not be withheld in stroke patients simply because of advanced age.
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