A critical review: vitamin b deficiency and nervous disease.
C. D. Aring,Tom Douglas Spies +1 more
TLDR
The artificial synthesis of a number of the components of the vitamin B complex has made available pure crystalline material in large amounts for clinical research, and thus a milestone in the history of these affections has been passed.Abstract:
AFFECTIONS of the nervous system which result from inadequate nutrition have assumed an increasingly important position through the rapid accumulation of clinical, experimental, and pathological data. The artificial synthesis of a number of the components of the vitamin B complex has made available pure crystalline material in large amounts for clinical research, and thus a milestone in the history of these affections has been passed. It now seems appropriate to review and summarize the knowledge of these important substances. To evaluate the status of a nutritional deficiency in man is difficult. As a rule the patient induces his own disease and provides a deficiency that is not quantitatively measurable, but frequently clinical and laboratory evaluations are attempted. Both the laboratory method and the clinical method have certain advantages. Mice are not yet men and until they are the work coming -from the study of human beings is essential. Since the experience of investigators working with animals may often point the way for clinical research, we have interspersed in this review a few of the pertinent studies on the effect of nutritional deficiency on the nervous system of animals. A scheme for illustrating the multiple factors of the vitamin B complex is given in Fig. 1. To date the following portions of the vitamin B complex have been isolated and synthesized in amounts sufficient to allow for clinical trial: thiamin hydrochloride, nicotinic acid, riboflavin, and 2-methyl, 3-hydroxy, 4, 5-di (hydroxymethyl) pyridine. The deficiencies of these substances as they apply to the nervous system of man will be discussed briefly.read more
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Data fusion of vis–NIR and PXRF spectra to predict soil physical and chemical properties
Yakun Zhang,Alfred E. Hartemink +1 more
TL;DR: In this paper, a front-end data fusion method was used to combine visible near-infrared (vis-NIR) and portable X-ray fluorescence (PXRF) spectra for predicting different soil properties and investigated the contribution of different sensor data.
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T Cell Hierarchy in the Pathogenesis of Psoriasis and Associated Cardiovascular Comorbidities
TL;DR: A hierarchy for the different subsets of T cells in the T cell-mediated inflammatory cascade in psoriatic skin is defined to distinguish the subsets that initiate the disease, those involved in the establishment of the self-sustaining amplification loop that leads to the cutaneous clinical manifestations and finally the subset that act as downstream players in established lesions.
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Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue Engineering.
TL;DR: Current advancements in hydrogel-based drug sustained release systems that have delivered osteogenesis-inducing peptides, nucleic acids, and other bioactive molecules in bone tissue engineering (BTE) are reviewed.
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Normal red blood cells' shape stabilized by membrane's in-plane ordering.
Luka Mesarec,Wojciech T. Góźdź,Aleš Iglič,Aleš Iglič,Veronika Kralj-Iglič,Veronika Kralj-Iglič,Epifanio G. Virga,Samo Kralj +7 more
TL;DR: It is shown on symmetry grounds that the role of extrinsic curvature is anomalously increased just below the nematic in-plane order-disorder phase transition temperature, which stabilizes the RBC discocyte shapes.
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Inflammation-Induced Adverse Pregnancy and Neonatal Outcomes Can Be Improved by the Immunomodulatory Peptide Exendin-4.
Valeria Garcia-Flores,Valeria Garcia-Flores,Valeria Garcia-Flores,Roberto Romero,Derek Miller,Derek Miller,Yi Xu,Yi Xu,Bogdan Done,Bogdan Done,Chharitha Veerapaneni,Yaozhu Leng,Yaozhu Leng,Marcia Arenas-Hernandez,Marcia Arenas-Hernandez,Marcia Arenas-Hernandez,Nabila Khan,Bogdan Panaitescu,Bogdan Panaitescu,Sonia S. Hassan,Sonia S. Hassan,Luis Marat Alvarez-Salas,Nardhy Gomez-Lopez,Nardhy Gomez-Lopez +23 more
TL;DR: Evidence is provided that dampening maternal systemic inflammation through novel interventions, such as Ex4, can improve the quality of life for neonates born to women with this clinical condition.
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