Journal ArticleDOI
A dose-response study of testosterone on sexual dysfunction and features of the metabolic syndrome using testosterone gel and parenteral testosterone undecanoate.
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T administration had a beneficial effect on sexual dysfunction and symptoms of the metabolic syndrome in elderly men and the higher plasma levels of T generated with TU than with T gel were clearly more effective, indicating that there is a T dose-effect relationship.Abstract:
The objective of this study was to observe the dose-response effects of testosterone (T) treatment on symptoms of sexual dysfunction and the metabolic syndrome. Two cohorts of elderly men with late-onset hypogonadism were followed over 9 months. Group 1, consisting of 28 men (mean age, 61 years; mean T level, 2.07 +/- 0.50 ng/mL), received long-acting T undecanoate (TU; 1000 mg); group 2, composed of 27 men (mean age, 60 years; mean T level, 2.24 +/- 0.41 ng/mL), received T gel (50 mg/day) for 9 months. In patients treated with T gel, plasma T levels rose from 2.24 +/- 0.41 to 2.95 +/- 0.52 (statistically significant) at 3 months, 3.49 +/- 0.89 (statistically significant) at 6 months, and 3.80 +/- 0.73 ng/mL at 9 months (T level at 6 months was compared with T level at 3 months). With TU, plasma T levels rose from 2.08 +/- 0.56 to 4.81 +/- 0.83 (statistically significant) at 3 months, 5.29 +/- 0.91 at 6 months, and 5.40 +/- 0.77 ng/mL at 9 months. With TU, the plasma T levels were statistically significantly higher than with T gel With TU, there was a greater improvement in sexual symptoms and in symptoms of the metabolic syndrome. With both treatments, changes in waist circumference correlated with changes in total, low-density, and high-density lipoprotein cholesterol. Parameters of safety were not different between the 2 treatments. T administration had a beneficial effect on sexual dysfunction and symptoms of the metabolic syndrome in elderly men. The higher plasma levels of T generated with TU than with T gel were clearly more effective, indicating that there is a T dose-effect relationship.read more
Citations
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The metabolic syndrome
TL;DR: The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated, and a proinflammatory state probably contributes to the metabolic syndrome.
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The Metabolic Syndrome
Marc-Andre Cornier,Dana Dabelea,Teri L. Hernandez,Rachel C. Lindstrom,Amy J. Steig,Nicole R. Stob,Rachael E. Van Pelt,Hong Wang,Robert H. Eckel +8 more
TL;DR: The "metabolic syndrome" is a clustering of components that reflect overnutrition, sedentary lifestyles, and resultant excess adiposity that is associated with an approximate doubling of cardiovascular disease risk and a 5-fold increased risk for incident type 2 diabetes mellitus.
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Testosterone: a metabolic hormone in health and disease
Daniel Kelly,T. Hugh Jones +1 more
TL;DR: Current knowledge of the metabolic actions of testosterone and how testosterone deficiency contributes to the clinical disease states of obesity, MetS and type 2 diabetes and the role of testosterone replacement are discussed.
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Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double‐blinded placebo‐controlled Moscow study
Svetlana Kalinchenko,Yuliya Tishova,George Mskhalaya,Louis Gooren,Erik J. Giltay,Farid Saad,Farid Saad +6 more
TL;DR: The aim of this study was to establish whether the normalization of plasma T improves the features of the MetS.
Journal ArticleDOI
The Dark Side of Testosterone Deficiency: I. Metabolic Syndrome and Erectile Dysfunction
TL;DR: The current literature pertaining to androgen deficiency, MetS, and ED is discussed, because the relationship of these factors is of scientific and clinical importance and a better understanding is needed of how obesity, diabetes and hypogonadism contribute to androgens deficiency and the various pathophysiologic states of vascular disease.
References
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Journal ArticleDOI
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TL;DR: Although ATP III identified CVD as the primary clinical outcome of the metabolic syndrome, most people with this syndrome have insulin resistance, which confers increased risk for type 2 diabetes, when diabetes becomes clinically apparent, CVD risk rises sharply.
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Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition.
TL;DR: Although ATP III identified CVD as the primary clinical outcome of the metabolic syndrome, most people with this syndrome have insulin resistance, which confers increased risk for type 2 diabetes, when diabetes becomes clinically apparent, CVD risk rises sharply.
Journal ArticleDOI
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Journal ArticleDOI
Testosterone and Sex Hormone–Binding Globulin Predict the Metabolic Syndrome and Diabetes in Middle-Aged Men
David E. Laaksonen,Leo Niskanen,Kari Punnonen,Kristiina Nyyssönen,Tomi-Pekka Tuomainen,Veli-Pekka Valkonen,Riitta Salonen,Jukka T. Salonen +7 more
TL;DR: Low total testosterone and SHBG levels independently predict development of the metabolic syndrome and diabetes in middle-aged men, and hypoandrogenism is an early marker for disturbances in insulin and glucose metabolism that may progress to the metabolic Syndrome or frank diabetes and may contribute to their pathogenesis.
Journal ArticleDOI
Testosterone dose-response relationships in healthy young men
Shalender Bhasin,Linda J. Woodhouse,Richard Casaburi,Atam B. Singh,Dimple Bhasin,Nancy Berman,Xianghong Chen,Kevin E. Yarasheski,Lynne Magliano,Connie Dzekov,Jeanne Dzekov,Rachelle Bross,Jeff M. Phillips,Indrani Sinha-Hikim,Ruoquing Shen,Thomas W. Storer +15 more
TL;DR: It is concluded that changes in circulating testosterone concentrations, induced by GnRH agonist and testosterone administration, are associated with testosterone dose- and concentration-dependent changes in fat-free mass, muscle size, strength and power, fat mass, hemoglobin, HDL cholesterol, and IGF-I levels, in conformity with a single linear dose-response relationship.
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