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A Meta-Analysis of Interventions to Reduce Loneliness:

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TLDR
An integrative meta-analysis of loneliness reduction interventions was conducted to quantify the effects of each strategy and to examine the potential role of moderator variables, and revealed that single-group pre-post and nonrandomized comparison studies yielded larger mean effect sizes relative to randomized comparison studies.
Abstract
Social and demographic trends are placing an increasing number of adults at risk for loneliness, an established risk factor for physical and mental illness. The growing costs of loneliness have led to a number of loneliness reduction interventions. Qualitative reviews have identified four primary intervention strategies: (a) improving social skills, (b) enhancing social support, (c) increasing opportunities for social contact, and (d) addressing maladaptive social cognition. An integrative meta-analysis of loneliness reduction interventions was conducted to quantify the effects of each strategy and to examine the potential role of moderator variables. Results revealed that single-group pre-post and nonrandomized comparison studies yielded larger mean effect sizes relative to randomized comparison studies. Among studies that used the latter design, the most successful interventions addressed maladaptive social cognition. This is consistent with current theories regarding loneliness and its etiology. Theoretical and methodological issues associated with designing new loneliness reduction interventions are discussed.

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Loneliness associates strongly with anxiety and depression during the COVID pandemic, especially in men and younger adults

TL;DR: In this paper , the authors used generalized estimating equations to investigate the association between loneliness and major depressive disorder (MDD), and whether this association varied across time, age, sex and MDD polygenic risk.
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A comparison of different definitions of social isolation using Canadian Longitudinal Study on Aging (CLSA) data

TL;DR: In this paper, the authors compared single-item and composite measures of social isolation in the Canadian Longitudinal Study on Aging (CLSA) and found that the composite measures showed less variation across socio-demographics than single item measures.
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Loneliness and the onset of new mental health problems in the general population: a systematic review

TL;DR: In this article, the authors synthesized evidence from longitudinal studies investigating the relationship between loneliness and new onset of mental health problems, in the general population, up to March 2020, and found a pooled adjusted odds ratio of 2.33 (95% C.I. 1.62 to 3.34) for risk of new onset depression in adults who were often lonely compared with people who were not often lonely.
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Loneliness Trajectories: Evidence for Staged Intervention Among Chinese Bereaved Parents:

TL;DR: The findings indicate that trajectories of perceived loneliness have three distinct stages and follow a U-shape in their frequency and intensity.
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Effects of Emotional Expressiveness of a Female Digital Human on Loneliness, Stress, Perceived Support, and Closeness Across Genders: Randomized Controlled Trial

TL;DR: Emotional expressiveness in a female digital human has different effects on loneliness, social, and physiological outcomes for men and women, and user gender moderated the effect of emotional expressiveness on several outcomes.
References
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Book

Practical Meta-Analysis

TL;DR: This paper presents a meta-analysis procedure called “Meta-Analysis Interpretation for Meta-Analysis Selecting, Computing and Coding the Effect Size Statistic and its applications to Data Management Analysis Issues and Strategies.
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