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A Meta-Analysis of Interventions to Reduce Loneliness:

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TLDR
An integrative meta-analysis of loneliness reduction interventions was conducted to quantify the effects of each strategy and to examine the potential role of moderator variables, and revealed that single-group pre-post and nonrandomized comparison studies yielded larger mean effect sizes relative to randomized comparison studies.
Abstract
Social and demographic trends are placing an increasing number of adults at risk for loneliness, an established risk factor for physical and mental illness. The growing costs of loneliness have led to a number of loneliness reduction interventions. Qualitative reviews have identified four primary intervention strategies: (a) improving social skills, (b) enhancing social support, (c) increasing opportunities for social contact, and (d) addressing maladaptive social cognition. An integrative meta-analysis of loneliness reduction interventions was conducted to quantify the effects of each strategy and to examine the potential role of moderator variables. Results revealed that single-group pre-post and nonrandomized comparison studies yielded larger mean effect sizes relative to randomized comparison studies. Among studies that used the latter design, the most successful interventions addressed maladaptive social cognition. This is consistent with current theories regarding loneliness and its etiology. Theoretical and methodological issues associated with designing new loneliness reduction interventions are discussed.

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How social isolation and loneliness effect medication adherence among elderly with chronic diseases: An integrated theory and validated cross-sectional study.

TL;DR: Interconnected psychosocial mechanisms explain the influence the mechanism of medication adherence from social isolation and loneliness, and the effective paths of social isolation will increase as the chronic disease evolves.
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Changes in adolescent loneliness and concomitant changes in fear of negative evaluation and self-esteem:

TL;DR: In this article, the authors test the assumption that biases in social information processing play a key role in the development and maintenance of loneliness and show that this assumption has rarely been tested.
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Differential transcriptome expression in human nucleus accumbens as a function of loneliness

TL;DR: Examination of genome-wide RNA expression in post-mortem nucleus accumbens from donors with known loneliness measures identifies novel targets for future mechanistic studies of gene networks in nucleus Accumbens and gene regulatory mechanisms across a variety of diseases exacerbated by loneliness.
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The Need to Belong and the Relationship Between Loneliness and Health

TL;DR: In this paper, individual differences in the need to belong were found to moderate the relationship between loneliness and current health state, which implies that social isolation negatively affects individuals' health negatively.
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A Lonely Search?: Risk for Depression When Spirituality Exceeds Religiosity.

TL;DR: In support of the hypothesis, greater spirituality than religiosity significantly predicted subsequent increases in depressive symptoms and risk for major depressive disorder (odds ratio = 1.34).
References
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Book

Practical Meta-Analysis

TL;DR: This paper presents a meta-analysis procedure called “Meta-Analysis Interpretation for Meta-Analysis Selecting, Computing and Coding the Effect Size Statistic and its applications to Data Management Analysis Issues and Strategies.
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