Journal ArticleDOI
A novel automated microchip flow‐chamber system to quantitatively evaluate thrombus formation and antithrombotic agents under blood flow conditions
K. Hosokawa,Tomoko Ohnishi,T. Kondo,M. Fukasawa,Takehiko Koide,Ikuro Maruyama,Kenichi A. Tanaka +6 more
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TLDR
The novel monitoring system of WTF may be useful in preclinical and clinical evaluations of different types of antithrombotic strategies, and their effects in combination.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2011-10-01. It has received 129 citations till now. The article focuses on the topics: Thrombus & Platelet aggregation inhibitor.read more
Citations
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A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function
Abhishek Jain,Amanda R. Graveline,Anna Waterhouse,Andyna Vernet,Robert Flaumenhaft,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +7 more
TL;DR: A microfluidic device that mimics a network of stenosed arteriolar vessels, permitting evaluation of blood clotting within small sample volumes under pathophysiological flow and producing real-time readouts of alterations in coagulation ex vivo that are more reliable than standard clotting assays are described.
Journal ArticleDOI
The utility of thromboelastography in inherited and acquired bleeding disorders.
TL;DR: Evaluation of global clotting function and the monitoring of haemostatic treatment in various clinical situations, not only in patients with genetic bleeding disorders, such as haemophilia, but also in patients undergoing cardiac surgery, liver transplantation or suffering from traumatic injury.
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Microfluidic Thrombosis under Multiple Shear Rates and Antiplatelet Therapy Doses
TL;DR: This quantitative and statistically validated study of the effects of a wide range of shear rate and antiplatelet therapy doses on occlusion times and thrombus detachment contributes to more accurate understanding of thrombosis and to models for optimizing patient treatment.
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Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf
Yukako Ono,Yuhuan Wang,Hidenori Suzuki,Shinichiro Okamoto,Yasuo Ikeda,Mitsuru Murata,Mortimer Poncz,Mortimer Poncz,Yumiko Matsubara +8 more
TL;DR: It is reported that a combination of nuclear factor erythroid-derived 2 p45 unit (p45NF-E2), Maf G, and Maf K can convert mouse fibroblast 3T3 cells and adult human dermal fibroblasts into MKs.
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Analysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions
Kazuya Hosokawa,Tomoko Ohnishi,Hisayo Sameshima,Naoki Miura,Takashi Ito,Takehiko Koide,Ikuro Maruyama +6 more
TL;DR: It is suggested that residual platelet thrombogenicity in aspirin-treated patients is associated with either collagen-induced platelet aggregation or circulating platelet-monocyte aggregates, but it is predominantly dependent on ADP-induced Platelet aggregation in patients receiving dual antiplatelet therapy.
References
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Stability and Instability: Two Faces of Coronary Atherosclerosis: The Paul Dudley White Lecture 1995
TL;DR: Paul Dudley White was an astute observer of ischemic heart disease who emphasized the unity of acute myocardial infarction and chronic exertional angina as facets of the clinical expression of coronary atherosclerosis.
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Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices
Michael T. Ganter,C. K. Hofer +1 more
TL;DR: Viscoelastic POC coagulation devices may help identify the cause of bleeding and guide pro- and anticoagulant therapies, and in diagnosing of a surgical bleeding.
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Tissue Factor Modulates the Thrombogenicity of Human Atherosclerotic Plaques
Vincenzo Toschi,Richard L. Gallo,M. Lettino,John T. Fallon,S. D. Gertz,Antonio Fernández-Ortiz,James H. Chesebro,Lina Badimon,Yale Nemerson,Valentin Fuster,Juan J. Badimon +10 more
TL;DR: The results show that tissue factor is present in lipid-rich human atherosclerotic plaques and suggest that it is an important determinant of the thrombogenicity of human atheosclerotic lesions after spontaneous or mechanical plaque disruption.
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Description of an in vitro platelet function analyzer--PFA-100.
TL;DR: It is found that impairment of von Willebrand factor, or inhibition of platelet receptors glycoprotein Ib or IIb/IIIa with monoclonal antibodies or peptides, resulted in abnormal closure times.
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Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis
Christoph Kleinschnitz,Guido Stoll,Martin Bendszus,Kai Schuh,H. U. Pauer,Peter Burfeind,Christoph Renné,David Gailani,Bernhard Nieswandt,Thomas Renné +9 more
TL;DR: As FXII appears to be instrumental in pathologic fibrin formation but dispensable for hemostasis, FXII inhibition may offer a selective and safe strategy for preventing stroke and other thromboembolic diseases.