Journal ArticleDOI
A Novel L-Proline Catalyzed Biginelli Reaction : One-Pot Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones under Solvent-Free Conditions
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In this paper, an efficient and simple protocol for the Biginelli reaction has been developed for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones in a one-pot three-component condensation of aldeh...Abstract:
A Novel efficient and simple synthetic protocol for the Biginelli reaction has been developed for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones in a one-pot three-component condensation of aldeh...read more
Citations
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Journal ArticleDOI
Efficient one-pot synthesis of spirooxindole derivatives catalyzed by L-proline in aqueous medium.
TL;DR: An efficient one-pot synthesis of spirooxindole derivatives by three-component reaction of isatins, malononitrile and 1,3-dicarbonyl compounds in water in the presence of l-proline is reported.
Journal ArticleDOI
L-Proline: an efficient catalyst for the one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles
TL;DR: In this paper, a 3-component cyclocondensation of 1,2-dicarbonyl compound, aldehyde and ammonium acetate using l -proline as a catalyst in methanol at moderate temperature was achieved.
Journal ArticleDOI
Synthesis of polyhydroquinoline derivatives through unsymmetric Hantzsch reaction using organocatalysts
Atul Kumar,Ram Awatar Maurya +1 more
TL;DR: In this paper, a green approach for efficient and rapid synthesis of polyhydroquinoline derivatives via unsymmetric Hantzsch reaction using organocatalysts at room temperature was reported.
Journal ArticleDOI
A chemical placebo: NaCl as an effective, cheapest, non-acidic and greener catalyst for Biginelli-type 3,4-dihydropyrimidin-2(1H)-ones (-thiones) synthesis.
TL;DR: This work reduces the “yet-another-one-catalyst” idea to absurdity by proposing NaCl promotes the reaction that actually requires no catalyst, neither rare nor expensive.
Journal ArticleDOI
l-Proline catalyzed selective synthesis of 2-aryl-1-arylmethyl-1H-benzimidazoles ☆
TL;DR: In this article, the synthesis of 2-aryl-1-arylmethyl-1 H -benzimidazoles from a wide range of substituted o -phenylenediamines and aldehydes under mild conditions using chloroform as a solvent at ambient temperature.
References
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Journal ArticleDOI
Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen
Thomas U. Mayer,Tarun M. Kapoor,Stephen J. Haggarty,Stephen J. Haggarty,Randall W. King,Stuart L. Schreiber,Stuart L. Schreiber,Timothy J. Mitchison +7 more
TL;DR: In vitro, monastrol specifically inhibited the motility of the mitotic kinesin Eg5, a motor protein required for spindle bipolarity, and will therefore be a particularly useful tool for studying mitotic mechanisms.
Journal ArticleDOI
Biologically active dihydropyrimidones of the Biginelli-type--a literature survey.
TL;DR: This review highlights recent developments in the synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones with a focus on the DHPMs recently developed as calcium channel modulators, alpha(1a) adrenoceptor-selective antagonists and compounds that target the mitotic machinery.
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Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog.
TL;DR: This Account highlights recent developments in the Biginelli reaction in areas such as solid-phase synthesis, combinatorial chemistry, and natural product synthesis.
Journal ArticleDOI
The proline-catalyzed direct asymmetric three-component Mannich reaction: Scope, optimization, and application to the highly enantioselective synthesis of 1,2-amino alcohols
TL;DR: Proline-catalyzed direct asymmetric three-component Mannich reactions of ketones, aldehydes, and amines are developed and application to the highly enantioselective synthesis of 1,2-amino alcohols is presented.