Journal ArticleDOI
A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage.
Barbara L. Schumacher,Joel A. Block,Thomas M. Schmid,Margaret B. Aydelotte,Klaus E. Kuettner +4 more
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TLDR
A novel proteoglycan (PG) has been identified in culture medium from thin slices of the superficial zone of bovine articular cartilage and may serve as a functional metabolic marker for chondrocytes of the shallow zone of articular Cartilage.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1994-05-01. It has received 404 citations till now. The article focuses on the topics: Proteoglycan 4 & Chondroitin sulfate.read more
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Journal ArticleDOI
The surface of articular cartilage contains a progenitor cell population.
Gary P. Dowthwaite,Joanna Bishop,Samantha Redman,Ilyas M. Khan,Paul Rooney,Darrell J. R. Evans,Laura Haughton,Zubeyde Bayram,Sam Boyer,Brian Mark Thomson,Michael S. Wolfe,Charles W. Archer +11 more
TL;DR: The identification of a chondrocyte subpopulation with progenitor-like characteristics will allow for advances in the understanding of both cartilage growth and maintenance as well as provide novel solutions to articular cartilage repair.
Journal ArticleDOI
Articular cartilage and changes in Arthritis: Cell biology of osteoarthritis
Linda J. Sandell,Thomas Aigner +1 more
TL;DR: The reaction patterns of chondrocytes in osteoarthritis can be summarized in five categories: proliferation and cell death (apoptosis); changes in synthetic activity and degradation; changes in phenotypic modulation of the articular chondROcytes; and formation of osteophytes.
Journal ArticleDOI
The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
David K. Rhee,Jose Marcelino,MacArthur Baker,Yaoqin Gong,Patrick Smits,Véronique Lefebvre,Gregory D. Jay,Matthew C. Stewart,Hongwei Wang,Matthew L. Warman,John D. Carpten,John D. Carpten +11 more
TL;DR: It is concluded that lubricin has multiple functions in articulating joints and tendons that include the protection of surfaces and the control of synovial cell growth.
Journal ArticleDOI
Boundary lubrication of articular cartilage: Role of synovial fluid constituents
Tannin A. Schmidt,Nicholas S. Gastelum,Quynhhoa T. Nguyen,Barbara L. Schumacher,Robert L. Sah +4 more
TL;DR: The results described here indicate that SF constituents contribute, individually and in combination, both at physiologic and pathophysiologic concentrations, to the boundary lubrication of apposing articular cartilage surfaces.
Journal ArticleDOI
Basic science of articular cartilage and osteoarthritis.
TL;DR: Mechanically mediated and cytokine-mediated pathways ofcartilage degeneration have been identified in the pathogenesis of OA and further insight into the basic science of cartilage and OA is necessary to develop diagnostic and treatment strategies for this pervasive disease.
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