Journal ArticleDOI
A rating scale for extrapyramidal side effects
Reads0
Chats0
TLDR
A modification of an earlier rating scale for extrapyramidal system disturbance is described, and evidence for the validity and reliability of the scale is presented.Abstract:
SUMMARY
A modification of an earlier rating scale for extrapyramidal system disturbance is described, and evidence for the validity and reliability of the scale is presented. The usefulness of the scale in studies of neuroleptic drugs is discussed. By its application it is possible to quantify extrapyramidal side effects and to separate them into four principal factors.read more
Citations
More filters
Journal ArticleDOI
Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study.
TL;DR: Aripiprazole exhibits a unique occupancy profile as compared with other conventional and atypical antipsychotics, and the threshold for response appears to be higher than 60%, extrapyramidal side effects appear to be uncommon even at occupancies that exceed the conventional extrapYramidal Side effects threshold of 80%, and 5-HT(2) occupancy is lower than D( 2) occupancy.
Journal ArticleDOI
Clinical characteristics of akathisia. A systematic investigation of acute psychiatric inpatient admissions.
TL;DR: Assessment of drug-induced movement disorders was carried out regularly on 104 psychiatric patients requiring antipsychotic medication on admission to hospital, suggesting two distinct types of acute akathisia; one related to severe parkinsonism and one not.
Journal ArticleDOI
Randomised controlled trials of conventional antipsychotic versus new atypical drugs, and new atypical drugs versus clozapine, in people with schizophrenia responding poorly to, or intolerant of, current drug treatment.
Sarah Lewis,Linda Davies,Pamela Jones,Thomas R. E. Barnes,Robin M. Murray,Robert Kerwin,David Taylor,Karen P. Hayhurst,A. Markwick,Hannah Lloyd,Graham Dunn,Graham Dunn +11 more
TL;DR: There was a trend towards participants in the conventional drug group scoring more highly on the utility measure at 1 year, which suggests that the failure to find the predicted advantage for new atypicals was not due to inadequate recruitment and statistical power in this sample.
Journal ArticleDOI
Clinical pharmacokinetics of atypical antipsychotics: a critical review of the relationship between plasma concentrations and clinical response.
Massimo C. Mauri,L.S. Volonteri,Alessandro Colasanti,Alessio Fiorentini,Ilaria Francesca De Gaspari,Silvio R. Bareggi +5 more
TL;DR: This review of the literature concerning the relationships between plasma concentrations of SGAs and clinical responses is divided by dividing the studies on the basis of the length of their observation periods by indicating a relationship between clinical outcomes and plasma concentrations.
Journal ArticleDOI
Markers of Glutamatergic Neurotransmission and Oxidative Stress Associated With Tardive Dyskinesia
TL;DR: It is suggested that there are elevated levels of oxidative stress and glutamatergic neurotransmission in tardive dyskinesia, both of which may be relevant to the pathophysiology of tardiv dysKinesia.
References
More filters
Journal Article
Relationship of individual tolerance, behavior and phenothiazine produced extrapyramidal system disturbance.
Simpson Gm,Kunz-Bartholini E +1 more
Journal Article
Pharmacologically induced Parkinson-like signs as index of the therapeutic potential.
Journal ArticleDOI
The Action of Neuroleptic Drugs.
TL;DR: The major portion of this monograph consists of a restatement by the senior author of his concepts regarding the modus operandi and therapeutic use of the neuroleptic drugs in clinical psychiatry.