Journal ArticleDOI
A rating scale for extrapyramidal side effects
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TLDR
A modification of an earlier rating scale for extrapyramidal system disturbance is described, and evidence for the validity and reliability of the scale is presented.Abstract:
SUMMARY
A modification of an earlier rating scale for extrapyramidal system disturbance is described, and evidence for the validity and reliability of the scale is presented. The usefulness of the scale in studies of neuroleptic drugs is discussed. By its application it is possible to quantify extrapyramidal side effects and to separate them into four principal factors.read more
Citations
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Journal ArticleDOI
5-HT2 and D2 Receptor Occupancy of Olanzapine in Schizophrenia: A PET Investigation
Shitij Kapur,Robert B. Zipursky,Gary Remington,C. Jones,Jean N. DaSilva,Alan A. Wilson,Sylvain Houle +6 more
TL;DR: Olanzapine is a potent 5- HT2 blocker and shows a higher 5-HT2 than D2 occupancy at all doses, however, its D1 occupancy is higher than that of clozapine and similar to that of risperidone.
Journal ArticleDOI
Clinical and biologic response to clozapine in patients with schizophrenia. Crossover comparison with fluphenazine.
David Pickar,Richard R. Owen,Robert E. Litman,P. Eric Konicki,Rolando Gutierrez,Mark Hyman Rapaport +5 more
TL;DR: Clozapine significantly reduced total as well as positive and negative symptoms in comparison with both fluphenazine and placebo, and eight patients (38%) showed CLZAPINE superiority on the basis of prospective response criteria as discussed by the authors.
Journal ArticleDOI
Efficacy and Tolerability of Olanzapine, Quetiapine, and Risperidone in the Treatment of Early Psychosis: A Randomized, Double-Blind 52-Week Comparison
Joseph P. McEvoy,Jeffrey A. Lieberman,M.P.H. Diana O. Perkins,Robert M. Hamer,Hongbin Gu,M.B.A. Arthur Lazarus,Dennis Sweitzer,Christina Olexy,Peter J. Weiden,Stephen D. Strakowski +9 more
TL;DR: Olanzapine, quetiapines, and risperidone demonstrated comparable effectiveness in early-psychosis patients, as indicated by similar rates of all-cause treatment discontinuation.
Journal ArticleDOI
Childhood-onset schizophrenia: A double-blind clozapine-haloperidol comparison
Sanjiv Kumra,Jean A. Frazier,Leslie K. Jacobsen,Kathleen McKenna,Charles T. Gordon,Marge C. Lenane,Susan D. Hamburger,Amy Smith,Kathleen E. Albus,Javad Alaghband-Rad,Judith L. Rapoport +10 more
TL;DR: In this article, the efficacy and adverse effects of clozapine and haloperidol were compared for children and adolescents with early-onset schizophrenia in a 6-week double-blind parallel comparison.
Journal ArticleDOI
A rating scale for tardive dyskinesia.
TL;DR: A rating scale for tardive dyskinesia was developed, consisting of nearly all signs seen by two groups of investigators over a 5-year period, and has been shown to be both reliable and valid.
References
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Journal Article
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Journal Article
Pharmacologically induced Parkinson-like signs as index of the therapeutic potential.
Journal ArticleDOI
The Action of Neuroleptic Drugs.
TL;DR: The major portion of this monograph consists of a restatement by the senior author of his concepts regarding the modus operandi and therapeutic use of the neuroleptic drugs in clinical psychiatry.