Journal ArticleDOI
A rating scale for extrapyramidal side effects
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TLDR
A modification of an earlier rating scale for extrapyramidal system disturbance is described, and evidence for the validity and reliability of the scale is presented.Abstract:
SUMMARY
A modification of an earlier rating scale for extrapyramidal system disturbance is described, and evidence for the validity and reliability of the scale is presented. The usefulness of the scale in studies of neuroleptic drugs is discussed. By its application it is possible to quantify extrapyramidal side effects and to separate them into four principal factors.read more
Citations
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Journal ArticleDOI
AZD8529, a positive allosteric modulator at the mGluR2 receptor, does not improve symptoms in schizophrenia: A proof of principle study.
Robert E. Litman,Mark A. Smith,James J. Doherty,James J. Doherty,Alan J. Cross,Shane Raines,Lev Gertsik,Stephen R. Zukin,Stephen R. Zukin +8 more
TL;DR: The results indicate that positive modulation of mGluR type 2 receptors alone is not sufficient for antipsychotic effects in acutely ill schizophrenia patients, and suggests that risperidone demonstrated significant efficacy relative to placebo.
Journal ArticleDOI
A controlled assessment of propranolol in the treatment of neuroleptic-induced akathisia.
TL;DR: Patients with neuroleptic-induced akathisia were treated in a randomised, double-blind, cross-over design with propranolol and matching placebo, confirming prior findings of the efficacy of proPRanolol in akath isia induced by Neuroleptic treatment.
Journal ArticleDOI
A double-blind, placebo-controlled, randomized study evaluating the effect of paliperidone extended-release tablets on sleep architecture in patients with schizophrenia.
Remy Luthringer,Luc Staner,Nadine Noel,Muriel Muzet,Cristiana Gassmann-Mayer,K Talluri,Adriaan Cleton,Mariëlle Eerdekens,Wendy P. Battisti,Joseph Palumbo +9 more
TL;DR: Paliperidone extended-release was well tolerated and improved sleep architecture and sleep continuity in patients diagnosed with schizophrenia and concomitant insomnia.
Journal ArticleDOI
Lithium in the Acute Treatment of Bipolar I Disorder: A Double-Blind, Placebo-Controlled Study
Robert L. Findling,Adelaide S. Robb,Nora K. McNamara,Mani N. Pavuluri,Vivian Kafantaris,Russell E. Scheffer,Jean A. Frazier,Moira A. Rynn,Melissa P. DelBello,Robert A. Kowatch,Brieana M. Rowles,Jacqui Lingler,Karen Martz,Ravinder Anand,Traci E Clemons,Perdita Taylor-Zapata +15 more
TL;DR: Lithium was generally well tolerated in this patient population and was not associated with weight gain, distinguishing it from other agents commonly used to treat youth with bipolar disorder.
Journal ArticleDOI
Quetiapine versus haloperidol in the treatment of delirium: a double-blind, randomized, controlled trial.
TL;DR: Low-dose quetiapine and haloperidol may be equally effective and safe for controlling delirium symptoms.
References
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Journal Article
Relationship of individual tolerance, behavior and phenothiazine produced extrapyramidal system disturbance.
Simpson Gm,Kunz-Bartholini E +1 more
Journal Article
Pharmacologically induced Parkinson-like signs as index of the therapeutic potential.
Journal ArticleDOI
The Action of Neuroleptic Drugs.
TL;DR: The major portion of this monograph consists of a restatement by the senior author of his concepts regarding the modus operandi and therapeutic use of the neuroleptic drugs in clinical psychiatry.