Journal ArticleDOI
A rating scale for extrapyramidal side effects
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TLDR
A modification of an earlier rating scale for extrapyramidal system disturbance is described, and evidence for the validity and reliability of the scale is presented.Abstract:
SUMMARY
A modification of an earlier rating scale for extrapyramidal system disturbance is described, and evidence for the validity and reliability of the scale is presented. The usefulness of the scale in studies of neuroleptic drugs is discussed. By its application it is possible to quantify extrapyramidal side effects and to separate them into four principal factors.read more
Citations
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Journal ArticleDOI
Movement Disorders Induced by Antipsychotic Drugs: Implications of the CATIE Schizophrenia Trial
Stanley N. Caroff,Irene Hurford,Irene Hurford,Janice Lybrand,E. Cabrina Campbell,E. Cabrina Campbell +5 more
TL;DR: Data from the CATIE trial imply that advantages of second-generation antipsychotics in significantly reducing extrapyramidal side effects compared with haloperidol may be diminished when compared with modest doses of lower-potency first-generation drugs.
Journal ArticleDOI
Efficacy and Safety of Adjunctive Brexpiprazole 2 mg in Major Depressive Disorder: A Phase 3, Randomized, Placebo-Controlled Study in Patients With Inadequate Response to Antidepressants
Michael E. Thase,James M. Youakim,Aleksandar Skuban,Mary Hobart,Carole Augustine,Peter Zhang,Robert D. McQuade,William H. Carson,Margaretta Nyilas,Raymond Sanchez,Hans Eriksson +10 more
TL;DR: Adjunctive brexpiprazole therapy demonstrated efficacy and was well tolerated in patients with major depressive disorder and inadequate response to ADTs.
Journal ArticleDOI
Haloperidol versus placebo for schizophrenia
TL;DR: Adverse effect data does, nevertheless, support clinical impression that haloperidol is a potent cause of movement disorders, at least in the short term, and support risk of bias of included studies.
Journal ArticleDOI
Aripiprazole for the treatment of psychosis in patients with Alzheimer's disease: a randomized, placebo-controlled study
Peter Paul De Deyn,Dilip V. Jeste,Rene Swanink,Dusan Kostic,Christopher D. Breder,William H. Carson,Taro Iwamoto +6 more
TL;DR: Aripiprazole showed similar improvements to placebo in psychotic symptoms as assessed by NPI Psychosis subscale scores, but significantly greater effects on BPRS Core and Psychosis assessments in community-living AD patients with psychosis.
Journal ArticleDOI
South Westminster schizophrenia survey. Alcohol use and its relationship to symptoms, tardive dyskinesia and illness onset.
TL;DR: The highest levels of alcohol consumption were associated with more severe orofacial dyskinesia, suggesting that alcohol use may be an added risk factor for the development of tardive dyskinisia in some patients.
References
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Journal Article
Relationship of individual tolerance, behavior and phenothiazine produced extrapyramidal system disturbance.
Simpson Gm,Kunz-Bartholini E +1 more
Journal Article
Pharmacologically induced Parkinson-like signs as index of the therapeutic potential.
Journal ArticleDOI
The Action of Neuroleptic Drugs.
TL;DR: The major portion of this monograph consists of a restatement by the senior author of his concepts regarding the modus operandi and therapeutic use of the neuroleptic drugs in clinical psychiatry.