Journal ArticleDOI
A rating scale for extrapyramidal side effects
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TLDR
A modification of an earlier rating scale for extrapyramidal system disturbance is described, and evidence for the validity and reliability of the scale is presented.Abstract:
SUMMARY
A modification of an earlier rating scale for extrapyramidal system disturbance is described, and evidence for the validity and reliability of the scale is presented. The usefulness of the scale in studies of neuroleptic drugs is discussed. By its application it is possible to quantify extrapyramidal side effects and to separate them into four principal factors.read more
Citations
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Placebo-controlled trial of lamotrigine added to conventional and atypical antipsychotics in schizophrenia.
Ilana Kremer,Agnes Vass,Agnes Vass,Ielena Gorelik,Gali Bar,Monica Blanaru,Daniel C. Javitt,Uriel Heresco-Levy,Uriel Heresco-Levy +8 more
TL;DR: Preliminary findings support the hypothesis that lamotrigine adjuvant treatment may improve positive symptoms and general psychopathology in schizophrenia, and suggest that beneficial effects may be achieved when lamOTrigine is added to both conventional and atypical antipsychotics, and warrant additional, larger scale trials.
Journal ArticleDOI
Long-term olanzapine therapy in the treatment of bipolar I disorder: an open-label continuation phase study
TL;DR: During up to 1 year of olanzapine therapy, either as monotherapy or in combination with lithium and/or fluoxetine, patients with bipolar disorder demonstrated significant improvement in mania and depression symptoms with a favorable safety profile.
Journal ArticleDOI
Incidence of Tardive Dyskinesia in Early Stages of Low-Dose Treatment With Typical Neuroleptics in Older Patients
Dilip V. Jeste,Jonathan P. Lacro,Barton W. Palmer,Enid Rockwell,M. Jackuelyn Harris,Michael P. Caligiuri +5 more
TL;DR: The risk of tardive dyskinesia in older outpatients is high, even with relatively short treatment with low doses of conventional neuroleptics.
Journal ArticleDOI
Dosage of haloperidol for schizophrenia.
TL;DR: It is suggested that dosages higher than 10 mg/d of haloperidol for most patients have no additional beneficial effect in the treatment of acute or exacerbated schizophrenia.
Journal ArticleDOI
Intramuscular aripiprazole for the treatment of acute agitation in patients with schizophrenia or schizoaffective disorder: a double-blind, placebo-controlled comparison with intramuscular haloperidol
Raisa Andrezina,Richard C. Josiassen,Ronald N. Marcus,Dan A. Oren,George Manos,Elyse Stock,William H. Carson,Taro Iwamoto +7 more
TL;DR: Results show that IM aripiprazole is an effective treatment, comparable to IM haloperidol, and well-tolerated for acute agitation in patients with schizophrenia.
References
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Journal Article
Relationship of individual tolerance, behavior and phenothiazine produced extrapyramidal system disturbance.
Simpson Gm,Kunz-Bartholini E +1 more
Journal Article
Pharmacologically induced Parkinson-like signs as index of the therapeutic potential.
Journal ArticleDOI
The Action of Neuroleptic Drugs.
TL;DR: The major portion of this monograph consists of a restatement by the senior author of his concepts regarding the modus operandi and therapeutic use of the neuroleptic drugs in clinical psychiatry.