A Recipe Composed of Chinese Herbal Active Components Regulates Hepatic Lipid Metabolism of NAFLD In Vivo and In Vitro.
Sheng-xi Meng,Qian Liu,Ya-jun Tang,Wen-jing Wang,Qingshan Zheng,Hua-jie Tian,Dongsheng Yao,Lin Liu,Jinghua Peng,Yu Zhao,Yi-Yang Hu,Qin Feng +11 more
TLDR
The results of verification experiment verified that ACG could significantly reduce hepatic TG contents of NAFL rats and mice, as well as the cellular TG content of FFA-induced HepG2 cells.Abstract:
This study is to investigate the therapeutic effects of the recipe composed of Atractylodes macrocephala polysaccharide, chlorogenic acid, and geniposide (named ACG) on experimental nonalcoholic fatty liver (NAFL). The research was divided into two parts as screening experiment and verification experiment. In the screening experiment, we used high-fat diet (HFD) induced NAFL rat model and uniform design to get the recipe from five Chinese herbal active components. In the verification experiment, HFD induced fatty liver rat and mouse NAFL models and free fatty acid (FFA) induced HepG2 cell model were used to verify the effects of ACG. According to the multiple regression equation of the hepatic triglyceride (TG) contents of each group in the screening experiment, the recipe ACG was obtained and the doses of Atractylodes macrocephala polysaccharide, chlorogenic acid, and geniposide for rats were 266.67, 3.33, and 45 mg/kg, respectively. The results of verification experiment verified that ACG could significantly reduce hepatic TG contents of NAFL rats and mice, as well as the cellular TG content of FFA-induced HepG2 cells. ACG could also improve HOMA-IR and hepatic mitochondrial ultrastructure of NAFL mice. Our study verified that ACG recipe could regulate lipid metabolism of NAFL in vivo and in vitro.read more
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Antioxidant, anti-hyperlipidemia and hepatic protection of enzyme-assisted Morehella esculenta polysaccharide.
Yuhan Dong,Yanran Qi,Min Liu,Xinling Song,Chen Zhang,Xun Jiao,Wenshuai Wang,Jianjun Zhang,Le Jia +8 more
TL;DR: The results suggested that the EnMPS can act as a natural candidate for developing drugs to reduce blood lipids, resist oxidation and protect the liver.
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Dehydroabietic acid alleviates high fat diet-induced insulin resistance and hepatic steatosis through dual activation of PPAR-γ and PPAR-α.
Xie Zhishen,Gao Gai,Wang Hui,Er-Wen Li,Yuan Yong,Xu Jiangyan,Zhenqiang Zhang,Wang Pan,Yu Fu,Huahui Zeng,Junying Song,Christian Hölscher,Hui Chen +12 more
TL;DR: DA is a dual-PPAR-α/γ and PPAR-γ partial agonist, which can attenuate IR and hepatic steatosis induced by HFD-consumption in mice.
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Anti-Obesity Attributes; UHPLC-QTOF-MS/MS-Based Metabolite Profiling and Molecular Docking Insights of Taraxacum officinale
Zain Ul Aabideen,Muhammad Waseem Mumtaz,Muhammad Akhtar,Hamid Mukhtar,Syed Ali Raza,Tooba Touqeer,Nazamid Saari +6 more
TL;DR: The study presents Taraxacum officinale as a potent source of functional bioactive ingredients to impart new insights into the existing pool of knowledge of naturopathic approaches towards obesity management.
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Protective effect of the new prepared Atractylodes macrocephala Koidz polysaccharide on fatty liver hemorrhagic syndrome in laying hens
Y.F. Miao,X.N. Gao,Danning Xu,M.C. Li,Z.S. Gao,Z.H. Tang,N.H. Mhlambi,W.J. Wang,W.T. Fan,X.Z. Shi,G.L. Liu,S.Q. Song +11 more
TL;DR: PAMK supplements could ameliorate HELP diet-induced liver injury through regulating activities of antioxidant enzymes and hepatic lipid metabolism, and could be a potential feedstuff additive to alleviate FLHS in laying hens.
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Characterization and anti-hyperlipidemia effects of enzymatic residue polysaccharides from Pleurotus ostreatus.
TL;DR: The results revealed that EnRPS at 400 mg/kg bw showed superior liver protective effects by ameliorating the AI, lowing the hepatic MPO, FFA, ADPN, TC and TG indicators, and improving the antioxidant status by enhancing liver enzyme activities.
References
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