Journal ArticleDOI
A rule to predict which enantiomer of a secondary alcohol reacts faster in reactions catalyzed by cholesterol esterase, lipase from Pseudomonas cepacia, and lipase from Candida rugosa
Romas J. Kazlauskas,Romas J. Kazlauskas,Alexandra N. E. Weissfloch,Aviva Rappaport,Louis A. Cuccia +4 more
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This article is published in Journal of Organic Chemistry.The article was published on 1991-04-01. It has received 870 citations till now. The article focuses on the topics: Lipase & Candida rugosa.read more
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Multi-substrate fingerprinting of esterolytic enzymes with a group of acetylated alcohols and statistic analysis of substrate spectrum
TL;DR: An array of 20 acetates of structurally diverse alcohols were designed and synthesized for rapidly fingerprinting the activities of newly discovered lipases or esterases, and the Shannon–Wiener index was adopted for the first time to quantitatively describe the breadth of substrate spectrum.
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Synthesis, Enantiomer Separation, and Absolute Configuration of 2,6-Oxygenated 9-Azabicyclo[3.3.1]nonanes
TL;DR: Both enantiomers of N-Boc protected diol 2b were converted into the corresponding enantiomerically pure diones 4b, the absolute configuration of which was determined by comparison of the experimental and simulated circular dichroism (CD) spectra, obtained by ab initio time-dependent density functional theory (TDDFT) calculations.
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An expedient chemo-enzymatic method for the synthesis of optically active masked 1,2-amino alcohols
Pankaj Gupta,Subhash C. Taneja,Bhahwal Ali Shah,Debaraj Mukherjee,Rajinder Parshad,Swapandeep Singh Chimni,Ghulam Nabi Qazi +6 more
TL;DR: In this article, the regioselective ring opening of epoxides using phthalimide was achieved by the use of co-solvents during kinetic resolution, which significantly improved the enantioselectivity with reduction in time.
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Lipase-catalyzed synthesis of chiral poly(ester amide)s with an alternating sequence of hydroxy acid and L/D-aspartate units
TL;DR: In this paper, a facile approach for the lipase-catalyzed synthesis of chiral L-/D-Asp-based poly(ester amide)s with alternating aspartate and hydroxyhexanoic acid (HA) units was developed.
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Enzymatic desymmetrization of a prochiral 1,3,5-pentanetriol derivative. Application to the synthesis of a cyanobacterial heterocyst glycolipid
TL;DR: In this paper, the most widespread heterocyst glycolipid of N 2 -fixing cyanobacteria has been obtained by PFL catalyzed hydrolysis of the corresponding diacetate.