Journal ArticleDOI
A rule to predict which enantiomer of a secondary alcohol reacts faster in reactions catalyzed by cholesterol esterase, lipase from Pseudomonas cepacia, and lipase from Candida rugosa
Romas J. Kazlauskas,Romas J. Kazlauskas,Alexandra N. E. Weissfloch,Aviva Rappaport,Louis A. Cuccia +4 more
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This article is published in Journal of Organic Chemistry.The article was published on 1991-04-01. It has received 870 citations till now. The article focuses on the topics: Lipase & Candida rugosa.read more
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Synthesis of deoxy sugar esters : A chemoenzymatic stereoselective approach affording deoxy sugar derivatives also in the form of aldehyde
Ly Villo,Kady Danilas,Andrus Metsala,Malle Kreen,Imre Vallikivi,Sirje Vija,Tõnis Pehk,Luciano Saso,Omar Parve +8 more
TL;DR: A chemoenzymatic synthesis of deoxy sugar esters is described, based on the O-alkylation of carboxylic acid with 2-bromo-5-acetoxypentanal, and the stereochemistry of the reactions was determined by the NMR spectra of mandelic acid derivatives.
Journal ArticleDOI
A Structural View on the Stereospecificity of Plant Borneol-Type Dehydrogenases.
Andrea M Chánique,Andrea M Chánique,Nicole Dimos,Ivana Drienovská,Elia Calderini,Mónica P. Pantín,Carl P. O. Helmer,Michael Hofer,Volker Sieber,Volker Sieber,Loreto P. Parra,Bernhard Loll,Robert Kourist +12 more
TL;DR: The kinetic resolution of borneol and isoborneol can be easily integrated into the existing synthetic route from α‐pinene to camphor thereby allowing the facile synthesis of optically pure monoterpenols from an abundant renewable source.
Journal ArticleDOI
A facial chemoenzymatic method for the preparation of chiral 1,2-dihydroxy-3,3,3,-trifluoropropanephosphonates
TL;DR: Enzymatic kinetic resolution of the resultant racemate by CALB or IM provided optically active 1,2-dihydroxy-3, 3,3,3-trifluoropropanephosphonate with satisfactory chemical and enantiomeric yield.
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Highly enantioselective enzymatic resolution of cis-fused octalols mediated by Candida antarctica lipase (Novozym 435)
TL;DR: Optically active cis -fused octalin acetates have been prepared by esterification of cis - fused octalols using Candida antarctica lipase using CALB—Novozym 435 with high enantiomeric excesses and good yields.
Journal ArticleDOI
Enzymatic transesterification of pharmacologically interesting β-aminocycloalkanol precursors
TL;DR: Most of the lipases exhibited excellent enantioselectivity in the transesterification reactions of trans-derivatives, with both N-protected (R,R)-amino acetates and (S,S-amino alcohols being isolated in enantiopure form.