Journal ArticleDOI
A rule to predict which enantiomer of a secondary alcohol reacts faster in reactions catalyzed by cholesterol esterase, lipase from Pseudomonas cepacia, and lipase from Candida rugosa
Romas J. Kazlauskas,Romas J. Kazlauskas,Alexandra N. E. Weissfloch,Aviva Rappaport,Louis A. Cuccia +4 more
Reads0
Chats0
About:
This article is published in Journal of Organic Chemistry.The article was published on 1991-04-01. It has received 870 citations till now. The article focuses on the topics: Lipase & Candida rugosa.read more
Citations
More filters
Journal ArticleDOI
Long-distance control in stereoselective reduction of 3-[3-(4′-bromo[1,1′-biphenyl]-4-yl)-3-keto-1-phenylpropyl]-4-hydroxy-2H-1-benzopyran-2-one: Relative configuration of prevailing diastereomer and absolute configuration of its enantiomers
Amir Avdagić,Livius Cotarca,Zdenko Hameršak,Miklós Hollósi,Zsuzsa Majer,Edina Ljubović,Andreja Šuste,Vitomir Šunjić +7 more
TL;DR: In this paper, the diastereomeric racemates 4A and 4B are separated and their respective syn and anti configurations are assigned on the bases of mechanic considerations, supported by the 1H-NMR spectra and conformational analysis based on MM2 calculations.
Journal ArticleDOI
Preparation of (R)- and (S)-4-chloro-3-acetoxybutyronitrile using microbial resolution
TL;DR: A new preparation of optically active 4-chloro-3-acetoxybutyronitrile (AcBN) was developed using the resting cells of bacteria based on enantioselective hydrolysis of the ester function of the substrate.
Journal ArticleDOI
Site-specifically Incorporated Non-Canonical Amino Acids into Pseudomonas alcaligenes Lipase to Hydrolyze L-menthol Propionate among the Eight Isomers
TL;DR: The four ncAAs were site‐specifically incorporated into a lipase (PaL) produced by Pseudomonas alcaligenes to explore its diastereopreference mechanism and several variants with significant improvement in the diastreopreference were obtained.
Journal ArticleDOI
A Semiautomated Structure-Based Method To Predict Substrates of Enzymes via Molecular Docking: A Case Study with Candida antarctica Lipase B
Zhiqiang Yao,Lujia Zhang,Bei Gao,Dongbing Cui,Feng-Qing Wang,Xiao He,John Z. H. Zhang,John Z. H. Zhang,Dongzhi Wei +8 more
TL;DR: An open-source, extensible, and flexible software platform for predicting enzyme substrates called THEMIS, which performs in silico virtual screening for potential catalytic targets of an enzyme on the basis of the enzyme's catalysis mechanism, and is perhaps the first reported scheme to meet the requirement for practical applicability to enzyme studies.
Journal ArticleDOI
Cutinases as stereoselective catalysts: Specific activity and enantioselectivity of cutinases and lipases for menthol and its analogs
An Su,Serpil Kiokekli,Mariam Naviwala,Abhijit N. Shirke,Ioannis V. Pavlidis,Richard A. Gross +5 more
TL;DR: Results of this study highlight that cutinases can provide important advantages relative to lipases for enantioselective transformation, most notably with bulky and sterically hindered substrates.