Journal ArticleDOI
A rule to predict which enantiomer of a secondary alcohol reacts faster in reactions catalyzed by cholesterol esterase, lipase from Pseudomonas cepacia, and lipase from Candida rugosa
Romas J. Kazlauskas,Romas J. Kazlauskas,Alexandra N. E. Weissfloch,Aviva Rappaport,Louis A. Cuccia +4 more
Reads0
Chats0
About:
This article is published in Journal of Organic Chemistry.The article was published on 1991-04-01. It has received 870 citations till now. The article focuses on the topics: Lipase & Candida rugosa.read more
Citations
More filters
Journal ArticleDOI
Kinetic resolution of (±)-5-bromo-12-oxa-pentacyclo-[6.2.1.16,9.02,7.02,10]dodeca-4-ene-3-endo-ol and (±)-5-bromo-13-oxa-pentacyclo[6.2.2.16,9.02,7.02,10]trideca-4-ene-3-endo-ol via Pseudomonas-mediated lipase-catalyzed transesterification
TL;DR: In this paper, the authors used three different types of lipases, including PS-C-Amano-I, to detect the transesterification of racemic alcohol to the acetate (−)-3 with 42% yield.
Journal ArticleDOI
Kinetic resolution of leishmanicidal meta and para (±)-2-[Hydroxy(nitrophenyl)methyl]acrylonitrile catalyzed by CALB: In vitro evaluations of separated meta (R), (S) and (R/S) adducts
Francisco José Seixas Xavier,José S.S. Neto,Patrícia Lima do Nascimento Néris,Márcia Rosa de Oliveira,Juliana A. Vale,Mário L. A. A. Vasconcellos +5 more
TL;DR: In this article, the acyl derivatives enantiomers of the Morita-Baylis-Hillman adduct (±)-2-[m-nitrophenyl)methyl]acrylonitrile (1) were efficiently separated by kinetic resolution catalyzed by lipase B from Candida antarctica giving(R)-1 and (R)-2 in very high enantioselectivity (>99% e.e.).
Journal ArticleDOI
Cloning, expression and characterization of a new 2-Cl-propionic acid ester hydrolase from B. subtilis
TL;DR: This enzyme may serve as a model protein to solve the structure of this type of hydrolytic enzymes, which is commonly found in gene clusters of non-ribosomal peptide synthetases.
Journal ArticleDOI
Lipase-catalyzed asymmetric acylation of boron cluster-containing secondary alcohols
TL;DR: Utilizing lipase TL, the resolution of carborane-containing alcohol 5 is succeeded in the resolution, synthesized as a progesterone receptor ligand candidate, and the activities of the two enantiomers are evaluated.
Journal ArticleDOI
Novel chemoenzymatic strategy for the synthesis of enantiomerically pure secondary alcohols with sterically similar substituents.
TL;DR: A novel chemoenzymatic strategy for the synthesis of enantiomerically pure secondary alcohols with sterically similar substituents is described, and the key step is the kinetic lipase-catalyzed resolution of racemic mixtures of substituted propargylic alcohols.