Journal ArticleDOI
Abrogation of cisplatin-induced nephrotoxicity in mice by alpha lipoic acid through ameliorating oxidative stress and enhancing gene expression of antioxidant enzymes.
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TLDR
In this paper, the authors investigated biochemical and molecular effects of alpha lipoic acid (ALA) to protect against cisplatin-induced nephrotoxicity in mice.About:
This article is published in European Journal of Pharmacology.The article was published on 2011-10-01. It has received 78 citations till now. The article focuses on the topics: Nephrotoxicity & Glutathione peroxidase.read more
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Journal ArticleDOI
Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions.
Rossella Marullo,Erica Werner,Natalya Degtyareva,Bryn S. Moore,Giuseppe Altavilla,Suresh S. Ramalingam,Paul W. Doetsch +6 more
TL;DR: Exposure to cisplatin induces a mitochondrial-dependent ROS response that significantly enhances the cytotoxic effect caused by nDNA damage and may lead to the design of novel therapeutic strategies to improve anticancer drug efficacy.
Journal ArticleDOI
Curcumin: A potentially powerful tool to reverse cisplatin-induced toxicity
TL;DR: In this review, a summary of the studies done to show the protective effects of curcumin against cisplatin failure and toxicity is provided.
Journal ArticleDOI
Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression.
Hua Chen,Gang Cao,Dan-Qian Chen,Ming Wang,Nosratola D. Vaziri,Zhihao Zhang,Jia-Rong Mao,Xu Bai,Ying-Yong Zhao +8 more
TL;DR: Metabolomics identified 12-ketodeoxycholic acid, taurochenodesoxycholics acid, LPC(15:0) and docosahexaenoic acid as biomarkers for early detection of tubulo-interstitial nephropathy and these biomarkers were reversed by treatment of irbesartan and ergone in AAN rats at week 24 and adenine-induced CKD rats.
Journal ArticleDOI
Oxidative Stress and BPA Toxicity: An Antioxidant Approach for Male and Female Reproductive Dysfunction.
TL;DR: Five classes of antioxidants—vitamins and co-factors, natural products (herbals and phytochemicals), melatonin, selenium, and methyl donors (used alone or in combination)—that have been found useful to counteract BPA toxicity in male and female reproductive functions are focused on.
Journal ArticleDOI
Biochemical and histological study of rat liver and kidney injury induced by Cisplatin.
TL;DR: In this paper, the authors investigated the involvement of oxidative stress in the pathogenesis of cisplatin-induced liver and kidney injury in Wistar rats and found that the levels of ALT, AST, BUN and creatinine and MDA of the kidney and liver were markedly increased especially at 48 and 72 h, whereas the activity of superoxide dismutase (SOD) was decreased after the injection of SOD.
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal ArticleDOI
Tissue sulfhydryl groups
TL;DR: A water-soluble (at pH 8) aromatic disulfide [5,5′-dithiobis(2-nitrobenzoic acid] has been synthesized and shown to be useful for determination of sulfhydryl groups.
Book ChapterDOI
Catalase in vitro
TL;DR: In this article, the catalytic activity of catalase has been investigated using ultraviolet (UV) spectrophotometry and Titrimetric methods, which is suitable for comparative studies for large series of measurements.
Book ChapterDOI
Microsomal lipid peroxidation.
John A. Buege,Steven D. Aust +1 more
TL;DR: This chapter discusses microsomal lipid peroxidation, a complex process known to occur in both plants and animals that involves the formation and propagation of lipid radicals, the uptake of oxygen, a rearrangement of the double bonds in unsaturated lipids, and the eventual destruction of membrane lipids.
Journal ArticleDOI
Apoptosis in the pathogenesis and treatment of disease
TL;DR: In multicellular organisms, homeostasis is maintained through a balance between cell proliferation and cell death, and recent evidence suggests that alterations in cell survival contribute to the pathogenesis of a number of human diseases.