Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance.
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Results from in vivo experiments in mice are shown that the prior feeding of protein antigen may reduce the subsequent absorption of that antigen without altering its elimination from the circulation, suggesting local immunity may be a function of local immunity.Abstract:
Antigenic proteins may be absorbed intact. We report here results from in vivo experiments in mice showing that the prior feeding of protein antigen may reduce the subsequent absorption of that antigen without altering its elimination from the circulation. This may be a function of local immunity. We have also shown that the same feeding regime can paradoxically induce a state of systemic tolerance and suggest that the two phenomena contribute to the safe handling of these antigens.read more
Citations
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New knowledge on pathogenesis of bacterial enteric infections as applied to vaccine development.
TL;DR: A review of available information leads to the conclusion that an oral vaccine consisting of a combination of antigens, intending to stimulate both antibacterial and antitoxic immunity, would be most likely to succeed.
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The regulation of immune responses to dietary protein antigens
TL;DR: Allan Mowat reviews the mechanisms underlying the induction of immunological tolerance after feeding proteins and suggests how a breakdown in oral tolerance may lead to potentially harmful hypersensitivity in the intestine.
Journal ArticleDOI
Systemic tolerance and secretory immunity after oral immunization.
TL;DR: It appears that intragastric administration of soluble or particulate antigens in mice may lead to the concurrent induction of salivary antibodies and systemic suppression.
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Plasmacytoid Dendritic Cells Mediate Oral Tolerance
Anne Goubier,Bertrand Dubois,Bertrand Dubois,Hanane Gheit,Hanane Gheit,Grégoire Joubert,Grégoire Joubert,Florence Villard-Truc,Carine Asselin-Paturel,Giorgio Trinchieri,Dominique Kaiserlian,Dominique Kaiserlian +11 more
TL;DR: It is shown that plasmacytoid dendritic cells (pDCs) prevented oral T cell priming and were responsible for systemic tolerance to CD4(+) and CD8(+) T cell-mediated DTH responses induced by Ag feeding, and suggested that pDC could represent a key therapeutic target for intestinal and systemic inflammatory diseases.
Journal ArticleDOI
Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen
TL;DR: Although oral administration of protein antigens may lead to specific immunologic unresponsiveness, this method of immunoregulation has not been applied to models of autoimmune disease and the overall magnitude of the antibody response is not significantly reduced in collagen-fed mice as compared to controls.
References
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Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity
W M Hunter,F. C. Greenwood +1 more
TL;DR: Current procedures for the immunological assay of protein hormones in human plasma require the routine preparation of hormones labelled with iodine-131 of high specific activity, and this work demonstrates the importance of knowing the carrier and removal status of iodine.
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Selective IgA deficiency: presentation of 30 cases and a review of the literature.
Arthur J. Ammann,Reichard Hong +1 more
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Inhibition of Experimental Drug Allergy by Prior Feeding of the Sensitizing Agent
TL;DR: Through the feeding of certain allergenic compounds to the non-sensitive subject, a state of resistance may be established against subsequent experimental sensitization of the skin by the same substance.
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Uptake and transport of macromolecules by the intestine: Possible role in clinical disorders (an update)
Ian R. Sanderson,W. Allan Walker +1 more
TL;DR: This review examines physiological transport of macromolecules through epithelia and through M cells and considers uncontrolled transport and its relation to disease states and the interrelationship between antigen transport and an altered immune system in the establishment of gastrointestinal disease.
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Prevention of eczema
TL;DR: Infants of allergic parents subjected to an allergen-avoidance regimen from birth for six months or managed conventionally had less eczema at six months and one year and had a lower mean serum-total-IgE level at six weeks.