scispace - formally typeset
Open AccessJournal ArticleDOI

Acetylation and methylation of histones and their possible role in the regulation of rna synthesis

V. G. Allfrey, +2 more
- 01 May 1964 - 
- Vol. 51, Iss: 5, pp 786-794
TLDR
17 Ohno, S., and B. M. deVenecia-Fernandez, Chromosoma, in press.
Abstract
17 Ohno, S., and B. M. Cattanach, Cytogenet., 1, 129 (1962). 18 Russell, L. B., Science, 140, 976 (1963). 19 Lyon, M. F., Genetic Res., 4, 93 (1963). *' Benirschke, K., R. J. Low, L. E. Brownhill, L. B. Caday, and J. deVenecia-Fernandez, Chromosoma, in press. 21 Davidson, R. G., H. M. Nitowsky, and B. Childs, these PROCEEDINGS, 50, 481 (1963). 22Beutler, E., and M. Baluda, Lancet, I, 189 (1964). 23 Bach, F., and K. Hirschhorn, Proc. 11th Intern. Congr. Genet., p. 312 (1963). 24Sanger, R., R. R. Race, P. Tippett, J. Hamper, J. Gavin, and T. E. Cleghorn, Vox Sang., 7, 571 (1962) 2 Gorman, J. G., A. M. Treacy, and A. Cahan, J. Lab. Clin. Med., 61, 642 (1963). 26Reed, T. E., N. E. Simpson, and B. Chown, Lancet, H, 467 (1963). 27 Lindsten, J., M. Fraccaro, P. E. Polani, J. L. Hamerton, R. Sanger, and R. R. Race, Nature, 197, 648 (1963). '\" Muldal, S., L. Tiepolo, M. Fraccaro, and J. Lindsten, unpublished data.

read more

Citations
More filters
Journal ArticleDOI

Regulation of chromatin by histone modifications

TL;DR: The known histone modifications are described, where they are found genomically and discussed and some of their functional consequences are discussed, concentrating mostly on transcription where the majority of characterisation has taken place.
Journal ArticleDOI

Cancer epigenetics: from mechanism to therapy.

TL;DR: The basic principles behind DNA methylation, histone modification, nucleosome remodeling, and RNA-mediated targeting are presented and the evidence suggesting that their misregulation can culminate in cancer is highlighted.
Journal ArticleDOI

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

TL;DR: Investigating aspects of HDACi action both in vitro and in vivo will further improve the design of optimized clinical protocols and help to understand the role of histone deacetylases in tumorigenesis.
Journal ArticleDOI

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

TL;DR: Results clearly indicate that TSA is a potent and specific inhibitor of the histone deacetylase and that the in vivo effect of TSA on cell proliferation and differentiation can be attributed to the inhibition of the enzyme.
Journal ArticleDOI

Histone acetylation and transcriptional regulatory mechanisms

TL;DR: Understanding of the causal relationship between histone acetylation and gene expression has been enhanced dramatically by the identification of proteins with intrinsic hist one acetylase and deacetylase activity, which led to a major paradigm shift in understanding of chromatin structure and transcription regulation.
Related Papers (5)