Journal ArticleDOI
Acquired hematopoietic stem-cell disorders and mammalian size.
TLDR
It is found that the advantage of large mammals at escaping the selective pressure of cancer cells is insufficient to overcome the increased risk of acquiring mutations, which favors smaller stem-cell pools and, consequently, smaller mammals, since these minimize the development of mutations in the active stem- cell pool.About:
This article is published in Blood.The article was published on 2007-12-01. It has received 23 citations till now. The article focuses on the topics: Hematopoietic stem cell & Stem cell.read more
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Journal ArticleDOI
B cells and immunosenescence: a focus on IgG+IgD-CD27- (DN) B cells in aged humans.
Matteo Bulati,Silvio Buffa,Giuseppina Candore,Calogero Caruso,Deborah K. Dunn-Walters,Mariavaleria Pellicanò,Yu-Chang Wu,Giuseppina Colonna Romano +7 more
TL;DR: Memory B cells and a subset of memory B cells (namely IgG(+)IgD(-)CD27(-)) that is demonstrated is increased in healthy elderly are demonstrated to be impaired in the elderly.
Journal ArticleDOI
The ecology of cancer from an evolutionary game theory perspective
TL;DR: A tutorial review of the central aspects of EGT, establishing a relation with the problem of cancer and how EGT can be applied to the study of the various manifestations and dynamics of multiple myeloma bone disease and its preceding condition known as monoclonal gammopathy of undetermined significance.
Journal ArticleDOI
Tyrosine kinase inhibitor therapy can cure chronic myeloid leukemia without hitting leukemic stem cells
TL;DR: Tyrosine kinase inhibitor therapy can cure chronic myeloid leukemia, although it may have to be prolonged and the depth of response increases with time in the vast majority of patients, illustrating the importance of stochastic effects on the dynamics of acquired hematopoietic stem cell disorders.
Journal ArticleDOI
Aging stem cells, latexin, and longevity.
Ying Liang,Gary Van Zant +1 more
TL;DR: Findings have been obtained under experimental conditions not encountered in nature that may enable clinical tissue regeneration for the treatment of a number of diseases and demonstrate the close affinity between at least some differentiated cells and the cells from which they ultimately arose.
Journal ArticleDOI
Modeling the architecture and dynamics of hematopoiesis
David Dingli,Jorge M. Pacheco +1 more
TL;DR: A model of hematopoiesis based on stochastic cell behavior is discussed that can be used to understand the dynamics of various disorders both in humans and in animal models.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI
Stem cells, cancer, and cancer stem cells
TL;DR: Stem cell biology has come of age: Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
Journal ArticleDOI
E.S. Jaffe, N.L. Harris, H. Stein, J.W. Vardiman (eds). World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues
Journal ArticleDOI
Cancer genes and the pathways they control.
TL;DR: The purposes of this review are to highlight examples of progress in many areas of cancer research, indicate where knowledge is scarce and point out fertile grounds for future investigation.
Journal ArticleDOI
Rates of Spontaneous Mutation
TL;DR: It is now possible to specify some of the evolutionary forces that shape these diverse mutation rates in broad groups of organisms.