Journal ArticleDOI
Activation of plasminogen by human plasma kallikrein.
TLDR
Hageman factor activation of fibrinolysis appears to be mediated by kallikrein-catalyzed formation of plasmin from plasmineogen, suggesting the formation of a stoichiometric equimolar complex of plAsmin and kallkrein in the course of the activation of pl asminogen by k allikreIn.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1969-04-29. It has received 204 citations till now. The article focuses on the topics: Plasmin & Kallikrein.read more
Citations
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Book ChapterDOI
Plasminogen activators, tissue degradation, and cancer.
Keld Danø,Peter A. Andreasen,J Grøndahl-Hansen,Peter Marcus Kristensen,L.S. Nielsen,L. Skriver +5 more
TL;DR: This chapter describes two types of plasminogen activators—namely, the urokinase-type plasMinogen activator (u-PA) and the tissue- type plasmineg activator(t-PA), which are essentially different gene products.
Journal ArticleDOI
The molecular basis of blood coagulation
Bruce Furie,Barbara C. Furie +1 more
TL;DR: This work focuses on the molecular basis of blood coagulation with particular attention to the biochemistry and regulation of this pathway as it relates to humans in health and disease.
Journal ArticleDOI
Molecular mechanisms of fibrinolysis.
TL;DR: The fundamental features of intravascular plasmin generation are reviewed, and the major clinical syndromes resulting from abnormalities in fibrinolysis are considered.
Journal ArticleDOI
Contact system: a vascular biology modulator with anticoagulant, profibrinolytic, antiadhesive, and proinflammatory attributes
TL;DR: The kallikrein-kinin system was first recognized as a plasma and tissue proteolytic system responsible for the liberation of the vasoactive, proinflammatory mediator, bradykinin (BK).
Journal ArticleDOI
The activation of pro-urokinase by plasma kallikrein and its inactivation by thrombin.
A Ichinose,K Fujikawa,T Suyama +2 more
TL;DR: Results indicate an important role of plasma kallikrein for the activation of pro-urokinase in the factor XII-dependent intrinsic pathway of fibrinolysis.
References
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Journal ArticleDOI
Waterfall sequence for intrinsic blood clotting.
Earl W. Davie,Oscar D. Ratnoff +1 more
TL;DR: A simple waterfall sequence is proposed to explain the function of the various protein clotting factors during the formation of the fibrin clot.
Journal ArticleDOI
An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier
TL;DR: It has been shown that contact activates Factor XII (Hageman factor) perhaps by unfolding its molecule, which leads successively to the activation of Factors XI (PTA) and IX (Christmas factor), and X (Stuart–Prower factor), the evidence suggesting that all these reactions are enzymatic.
Journal ArticleDOI
Investigation of serum trypsin and related substances: I. The quantitative demonstration of trypsinlike activity in human blood serum by a micromethod☆
TL;DR: Methanol released in hydrolysis of TAME is oxidized with permanganate to formaldehyde, and formaldehyde is determined colorimetrically after reaction with chromotropic acid.
Journal ArticleDOI
Studies on the prekallikrein (kallikreinogen)-kallikrein enzyme system of human plasma: I. Isolation and purification of plasma kallikreins
TL;DR: In this paper, three enzymatically active fractions were finally isolated and termed plasma kallikreins I, II, and III; they represented purifications of 970,320- and 590-fold, respectively.
Enzyme System of Human Plasma I. ISOLATION AND PURIFICATION OF PLASMA KALLIKREINS
Robert W. Colman,Sol Sierry +1 more
TL;DR: Three enzymatically active fractions were finally isolated and termed plasma kallikreins I, II, and III; they represented purifications of 970,320- and 590-fold, respectively, and had similar ratios of hydrolytic activity on a variety of arginine and lysine esters and were immunochemically related.
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Plasminogen: Purification from Human Plasma by Affinity Chromatography
Dale G. Deutsch,Edwin T. Mertz +1 more