Active prescription of low-dose aspirin during or prior to hospitalization and mortality in COVID-19: A systematic review and meta-analysis of adjusted effect estimates.
Januar Wibawa Martha,Raymond Pranata,Michael Anthonius Lim,Arief Wibowo,Mohammad Rizki Akbar +4 more
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In this paper, the authors investigated whether the active prescription of low-dose aspirin during or prior to hospitalization affects mortality in patients with coronavirus disease 2019 (COVID-19).About:
This article is published in International Journal of Infectious Diseases.The article was published on 2021-05-14 and is currently open access. It has received 32 citations till now. The article focuses on the topics: Aspirin & Relative risk.read more
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The effects of aspirin on the outcome of COVID-19: A systematic review and meta-analysis.
TL;DR: The use of aspirin was associated with a reduced risk of mortality (RR 0.56, 95% CI 0.38-0.81, P = 0.005) in patients with COVID-19, while the incidence of thrombosis and bleeding were considered as secondary outcomes as mentioned in this paper.
Journal ArticleDOI
Ivermectin and mortality in patients with COVID-19: A systematic review, meta-analysis, and meta-regression of randomized controlled trials.
Ahmad Fariz Malvi Zamzam Zein,Catur Setiya Sulistiyana,Wilson Matthew Raffaelo,Raymond Pranata +3 more
TL;DR: In this paper, the effect of ivermectin on mortality in patients with COVID-19 was investigated using a systematic review and meta-analysis, which showed that iverectin was associated with decreased mortality with a low certainty of evidence.
Journal ArticleDOI
Use of non-steroidal anti-inflammatory drugs and adverse outcomes during the COVID-19 pandemic: A systematic review and meta-analysis
Siya Zhao,Lidan Gan,Zhili Wang,Shuai Peng,Qinyuan Li,Hui Liu,Xiao Li,Zijun Wang,Qianling Shi,Janne Estill,Zhengxiu Luo,Xiaohui Wang,Enmei Liu,Yaolong Chen +13 more
TL;DR: The use of non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of adverse outcomes among patients with coronavirus COVID-19. as discussed by the authors conducted a meta-analysis on the main adverse outcomes, as well as selected subgroup analyses stratified by the type of NSAID and population.
Journal ArticleDOI
To Anticoagulate or Not to Anticoagulate in COVID-19: Lessons after 2 Years
John G. Rizk,Aashish Anand Gupta,Jose G. Lazo,Partha Sardar,Brandon Michael Henry,Carl J. Lavie,Mark B. Effron +6 more
TL;DR: In this article , the authors reviewed findings from randomized control trials (RCTs) in the past two years of antithrombotic therapy in critically ill hospitalized patients, noncritically ill hospital patients, patients postdischarge from the hospital, and outpatients.
Journal ArticleDOI
Does aspirin have an effect on risk of death in patients with COVID-19? A meta-analysis
Shaodi Ma,W Su,Chenyu Sun,Scott Lowe,Zhen Zhou,Haixia Liu,Guangbo Qu,Weihang Xia,Peng Xie,Birong Wu,Juan Gao,Linya Feng,Yehuan Sun +12 more
TL;DR: In this paper , a meta-analysis was performed to investigate the effects of aspirin on COVID-19 mortality, which showed that aspirin use was associated with a reduction in COVID19 mortality (adjusted RR 0.69; 95% CI 0.52-0.95; P < 0.001).
References
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The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses
TL;DR: The Newcastle-Ottawa Scale (NOS) as discussed by the authors was developed to assess the quality of nonrandomised studies with its design, content and ease of use directed to the task of incorporating the quality assessments in the interpretation of meta-analytic results.
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COVID-19: consider cytokine storm syndromes and immunosuppression
Puja Mehta,Daniel F. McAuley,Michael Brown,Emilie Sanchez,Rachel Tattersall,Rachel Tattersall,Jessica J Manson +6 more
TL;DR: Re-analysis of data from a phase 3 randomised controlled trial of IL-1 blockade (anakinra) in sepsis, showed significant survival benefit in patients with hyperinflammation, without increased adverse events.
Journal ArticleDOI
Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study.
Dominic Wichmann,Jan-Peter Sperhake,Marc Lütgehetmann,Stefan Steurer,Carolin Edler,Axel Heinemann,Fabian Heinrich,Herbert Mushumba,Inga Kniep,Ann Sophie Schröder,Christoph Burdelski,Geraldine de Heer,Axel Nierhaus,Daniel Frings,Susanne Pfefferle,Heinrich Becker,Hanns Bredereke-Wiedling,Andreas de Weerth,Hans-Richard Paschen,Sara Sheikhzadeh-Eggers,Axel Stang,Stefan Schmiedel,Carsten Bokemeyer,Marylyn M. Addo,Martin Aepfelbacher,Klaus Püschel,Stefan Kluge +26 more
TL;DR: In this paper, the causes of COVID-19-related deaths were investigated in a single academic medical center in the German federal state of Hamburg for patients dying with a polymerase chain reaction-confirmed diagnosis of CoV-19 patients.
Journal ArticleDOI
COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives.
TL;DR: The interaction between the viral spike protein and angiotensin-converting enzyme 2, which triggers entry of the virus into host cells, is likely to be involved in the cardiovascular manifestations of COVID-19.
Journal ArticleDOI
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.
Liuliu Yang,Yuling Han,Benjamin E. Nilsson-Payant,Vikas Gupta,Pengfei Wang,Xiaohua Duan,Xiaohua Duan,Xuming Tang,Jiajun Zhu,Zeping Zhao,Fabrice Jaffré,Tuo Zhang,Tae Wan Kim,Oliver Harschnitz,David Redmond,Sean Houghton,Chengyang Liu,Ali Naji,Gabriele Ciceri,Sudha R Guttikonda,Yaron Bram,Duc-Huy T. Nguyen,Michele Cioffi,Vasuretha Chandar,Daisy A. Hoagland,Yaoxing Huang,Jenny Xiang,Hui Wang,Hui Wang,David Lyden,Alain C. Borczuk,Huanhuan Joyce Chen,Lorenz Studer,Fong Cheng Pan,David D. Ho,Benjamin R. tenOever,Todd Evans,Robert E. Schwartz,Shuibing Chen +38 more
TL;DR: It is found that human pancreatic beta cells and liver organoids are highly permissive to SARS-CoV-2 infection, further validated using adult primary human islets and adult hepatocyte and cholangiocyte organoids.
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