Journal ArticleDOI
Acute phase gene expression in mice exposed to the marine neurotoxin domoic acid
TLDR
The transcriptional profile induced by domoic acid shared similarity with expression profiles of brain ischemia and other excitotoxins, suggesting a common transcriptional response.About:
This article is published in Neuroscience.The article was published on 2005-01-01. It has received 56 citations till now. The article focuses on the topics: Domoic acid & Excitotoxicity.read more
Citations
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Journal ArticleDOI
Microarray validation: factors influencing correlation between oligonucleotide microarrays and real-time PCR
TL;DR: Filtering of microarray data for measures of quality (fold-change and ρ-value) proves to be the most critical factor, with significant correlations of ρτ;0.80 consistently observed when quality scores are applied.
Journal ArticleDOI
Domoic acid and human exposure risks: A review
TL;DR: A basic description of the mechanism of action of domoic acid is provided as well as a synthesis of information pertaining to domeic acid exposure routes, toxin susceptibility, and the importance of effective monitoring programs are provided.
Journal ArticleDOI
Domoic acid toxicologic pathology: a review.
TL;DR: A comprehensive review of ASP, DOM induced pathology including ultrastructural changes associated to subchronic oral exposure, and discussion of key proposed mechanisms of cell/tissue injury involved in DOM induced brain pathology and considerations relevant to food safety and human health are provided.
Journal ArticleDOI
Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold
TL;DR: The evolutionary conservation of CIRP and RBM3 across species are summarized as well as their molecular interactions, cellular functions, and roles in diverse physiological and pathological processes, including circadian rhythm, inflammation, neural plasticity, stem cell properties, and cancer development.
Journal ArticleDOI
The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum.
Marcin Piechota,Michal Korostynski,Wojciech Solecki,Agnieszka Gieryk,Michal Slezak,Wiktor Bilecki,Barbara Ziółkowska,Elzbieta Kostrzewa,Iwona A. Cymerman,Lukasz Swiech,Jacek Jaworski,Ryszard Przewlocki +11 more
TL;DR: This study identified modules of drug-induced genes that share functional relationships that may play a critical role in the early stages of addiction, and Knockdown of the drug-responsive genes Sgk1 and Tsc22d3 resulted in alterations to dendritic spines in mice, possibly reflecting an altered potential for plastic changes.
References
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Journal ArticleDOI
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
TL;DR: The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases.
Journal ArticleDOI
Ischemic Cell Death in Brain Neurons
TL;DR: A major unifying thread of the review is a consideration of how the changes occurring during and after ischemia conspire to produce damaging levels of free radicals and peroxynitrite to activate calpain and other Ca(2+)-driven processes that are damaging, and to initiate the apoptotic process.
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Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
TL;DR: It is suggested that the large increase in the content of extracellular glutamate and aspartate in the hippocampus induced by the ischemic period may be one of the causal factors in the damage to certain neurons observed after ischemia.
Journal ArticleDOI
TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
TL;DR: The expression of the TIS10 gene appears to be highly cell type-restricted in cultured cell lines; of 12 cell lines tested under superinducing conditions, only the rodent embryonic Swiss 3T3 and Rat1 cell lines expressed TIS12 gene.
Journal ArticleDOI
cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase
TL;DR: There are both constitutive (2.8 kb) and regulated (4.1 kb) cyclooxygenase species, the latter most likely being a major mediator of inflammation.
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