Journal ArticleDOI
Adsorption kinetics of plasma proteins on ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles
TLDR
The results indicate that the existence of a Vroman effect, a displacement of previously adsorbed abundant proteins, on USPIO particles has to be denied and leads to the assumption of a long-lived ("hard") protein corona around the iron oxide nanoparticles.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2012-05-30. It has received 97 citations till now. The article focuses on the topics: Iron oxide nanoparticles & Protein Corona.read more
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Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle
TL;DR: Current knowledge on factors that influence nanoparticle-protein interactions and their implications on cellular uptake are summarized to help generate bio-compatible nanomaterials with controlled surface characteristics in a biological environment.
Journal ArticleDOI
Ultrasmall inorganic nanoparticles: State-of-the-art and perspectives for biomedical applications.
Kristof Zarschler,Louise Rocks,Nadia Licciardello,Nadia Licciardello,Luca Boselli,Ester Polo,Karina Pombo García,Luisa De Cola,Holger Stephan,Kenneth A. Dawson +9 more
TL;DR: This review overviews the different synthetic methods of inorganic ultrasmall nanoparticles as well as their properties, characterization, surface modification and toxicity, and summarizes the current state of knowledge regarding pharmacokinetics, biodistribution and targeting of nanoscale materials.
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Nanoparticle–protein corona complexes govern the biological fates and functions of nanoparticles
TL;DR: Taken together, the knowledge on the formation and biological effects of protein corona enables tailored tuning of the physicochemical characteristics of nanoparticles, unique to their intended biological activity.
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Engineered nanomaterial uptake and tissue distribution: from cell to organism.
TL;DR: Improved understanding of physicochemical properties of engineered nanoparticles and their influence on biological systems facilitates the design of nanomaterials that are safe, well tolerated, and suitable for diagnostic or therapeutic use in humans.
Journal ArticleDOI
Controlling the Stealth Effect of Nanocarriers through Understanding the Protein Corona
TL;DR: An overview of what the authors currently know about the characteristics of the protein corona of nanocarriers is provided, with a focus on surface functionalization that reduces unspecific uptake (the stealth effect).
References
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ExPASy: The proteomics server for in-depth protein knowledge and analysis.
Elisabeth Gasteiger,Alexandre Gattiker,Christine Hoogland,Ivan Ivanyi,Ron D. Appel,Amos Marc Bairoch +5 more
TL;DR: The ExPASy (the Expert Protein Analysis System) World Wide Web server, provided as a service to the life science community by a multidisciplinary team at the Swiss Institute of Bioinformatics, provides access to a variety of databases and analytical tools dedicated to proteins and proteomics.
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Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins
TL;DR: A new silver stain for electrophoretically separated polypeptides can be rapidly and easily used and can detect as little as 0.01 nanogram of protein per square millimeter when employed with two-dimensional electrophoresis.
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Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier.
Jörg Kreuter,D. A. Shamenkov,Petrov Ve,Peter Ramge,Klaus Cychutek,Claudia Koch-Brandt,Renad N. Alyautdin +6 more
TL;DR: The results suggest that apolipoproteins B and E are involved in the mediation of the transport of drugs bound to poly(butyl cyanoacrylate) nanoparticles across the BBB.
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Two‐dimensional electrophoresis of proteins: An updated protocol and implications for a functional analysis of the genome
Joachim Klose,Ursula Kobalz +1 more
TL;DR: It is shown how effectively 2‐DE of high resolution and reproducibility can be used to study the genetic variability of proteins in an interspecific mouse backcross established by the European Backcross Collaborative Group for mapping the mouse genome.
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Interaction of high molecular weight kininogen, factor XII, and fibrinogen in plasma at interfaces.
TL;DR: It is concluded that intact plasma will quickly replace the fibrinogen it has deposited on glass-like surfaces by high molecular weight kininogen and, to a smaller extent, by factor XII.