Journal ArticleDOI
Microneedle-Mediated Vaccination: Innovation and Translation.
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TLDR
In this article, a review of the development and application of microneedles for vaccination based on different delivery strategies is presented, and the potential for its application including opportunities and challenges are further discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2021-08-08. It has received 42 citations till now. The article focuses on the topics: Vaccination.read more
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Theranostic nanoparticles with disease-specific administration strategies
TL;DR: In this article , the authors summarize the state of the art for theranostic nanoparticles and discuss the diverse administration routes being used in the diagnosis and treatment of different diseases, including intravenous (IV) and newly emerging nanomaterial administration routes.
Journal ArticleDOI
Theranostic nanoparticles with disease-specific administration strategies
TL;DR: In this article, the authors summarize the state of the art for theranostic nanoparticles and discuss the diverse administration routes being used in the diagnosis and treatment of different diseases, highlighting the benefits, challenges, and opportunities of the nanostic nanoprobes and routes of administration to inform future nanoparticle design.
Journal ArticleDOI
Protein-Delivering Nanocomplexes with Fenton Reaction-Triggered Cargo Release to Boost Cancer Immunotherapy.
TL;DR: The nanocomplexes with Fenton reaction-triggered protein release show great potentials to improve the immunotherapeutic efficacy of ICB via combination with CDT.
Journal ArticleDOI
Microneedle Array Patch Made of Kangfuxin/Chitosan/Fucoidan Complex Enables Full-Thickness Wound Healing
Xixi Yu,CaiXia Wang,Yuanfei Wang,Longhao Li,Xiang Gao,Tingting Zhu,Pugen An,Zhaojian Meng,Wanchun Wang,Tong Wu,Yuanping Hao +10 more
TL;DR: A multifunctional microneedle array patch using a blend of kangfuxin (KFX), chitosan (CS), and fucoidan (FD), named KCFMN, for accelerating full-thickness wound healing was developed and it was shown that the K CFMN patch displayed noticeable antibacterial properties and good cytocompatibility.
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Artificial Intelligence-Assisted Bioinformatics, Microneedle, and Diabetic Wound Healing: A "New Deal" of an Old Drug.
Yanan Xue,Cheng Chen,Rong Tan,Jingyu Zhang,Qin Fang,Rui Jin,Xiangyu Mi,Danying Sun,Yinan Xue,Yude Wang,Rong Hua Xiong,Haojian Lu,Weiqiang Tan +12 more
TL;DR: The microneedle (MN) minimally invasive way to pierce the skin barrier for drug administration is developed and a swelling modified MN-mediated patch loaded with TSA is developed to reduce the probability of injection-caused iatrogenic secondary damage and find a broad spectrum of applications in related biomedical fields.
References
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Journal ArticleDOI
How dying cells alert the immune system to danger
Hajime Kono,Kenneth L. Rock +1 more
TL;DR: Current knowledge of cell death and repair processes in the host and their importance to host defence and disease pathogenesis has only been appreciated relatively recently is reviewed.
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Overview of the Immune Response
TL;DR: This overview identifies key mechanisms used by the immune system to respond to invading microbes and other exogenous threats and identifies settings in which disturbed immune function exacerbates tissue injury.
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Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
Christian Termeer,Frauke Benedix,Jonathon Sleeman,Christina Fieber,Ursula Voith,Thomas Ahrens,Kensuke Miyake,Marina A. Freudenberg,Christopher Galanos,Jan-Christoph Simon +9 more
TL;DR: This is the first report that polysaccharide degradation products of the extracellular matrix produced during inflammation might serve as an endogenous ligand for the TLR-4 complex on DCs.
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Microneedles for drug and vaccine delivery.
TL;DR: Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications.
Journal ArticleDOI
MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances
Stephen J. Galli,Janet Kalesnikoff,Michele A. Grimbaldeston,Adrian M. Piliponsky,Cara Williams,Mindy Tsai +5 more
TL;DR: It is proposed that mast cells are "tunable," by both genetic and environmental factors, such that, depending on the circumstances, the cell can be positioned phenotypically to express a wide spectrum of variation in the types, kinetics, and/or magnitude of its secretory functions.