African swine fever: A re-emerging viral disease threatening the global pig industry
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TLDR
Genotype II African swine fever virus (ASFV) circulating in Europe has high pathogenicity for domestic pigs and wild boar and relies on ‘stamping-out’ policies and control of pig movements, which have a significant impact on affected regions.Abstract:
African swine fever (ASF) recently has spread beyond sub-Saharan Africa to the Trans-Caucasus region, parts of the Russian Federation and Eastern Europe. In this new epidemiological scenario, the disease has similarities, but also important differences, compared to the situation in Africa, including the substantial involvement of wild boar. A better understanding of this new situation will enable better control and prevent further spread of disease. In this article, these different scenarios are compared, and recent information on the pathogenesis of ASF virus strains, the immune response to infection and prospects for developing vaccines is presented. Knowledge gaps and the prospects for future control are discussed.read more
Citations
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Journal ArticleDOI
African swine fever.
Linda K. Dixon,H. Sun,H. Roberts +2 more
TL;DR: In this review, what is known about the African swine fever virus, the disease it causes, how it spreads and the current global situation is summarized.
Journal ArticleDOI
African Swine Fever Epidemiology and Control
TL;DR: The epidemiology of African swine fever is reviewed in these different scenarios and methods used for control, and progress toward vaccine development and research priorities are discussed to better understand this complex disease and improve control.
Journal ArticleDOI
Architecture of African swine fever virus and implications for viral assembly
Nan Wang,Dongming Zhao,Jialing Wang,Yangling Zhang,Ming Wang,Yan Gao,Yan Gao,Fang Li,Jingfei Wang,Zhigao Bu,Zihe Rao,Xiangxi Wang +11 more
TL;DR: The structure reveals epitopes in the major capsid protein that distinguish ASFV from other nucleocytoplasmic large DNA viruses and shows how the minor capsid proteins stabilize the capsid, opening up new avenues for African swine fever vaccine development.
Journal ArticleDOI
A Proteomic Atlas of the African Swine Fever Virus Particle.
TL;DR: A comprehensive model of the ASFV architecture is provided that integrates both compositional and structural information and strongly supports the suggestion that these host membrane-associated proteins are recruited during virus budding at actin-dependent membrane protrusions.
Journal ArticleDOI
High-throughput and all-solution phase African Swine Fever Virus (ASFV) detection using CRISPR-Cas12a and fluorescence based point-of-care system.
Qian He,Dongmei Yu,Mengdi Bao,Grant Korensky,Juhong Chen,Mingyeong Shin,Juwon Kim,Myeongkee Park,Peiwu Qin,Ke Du +9 more
TL;DR: The development of a high throughput, all-solution phase, and isothermal detection system for African Swine Fever Virus, which shows that this system is very specific and can differentiate nucleic acid targets with closely matched sequences.
References
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Journal ArticleDOI
African Swine Fever virus. Brief review.
R C Wardley,C de M Andrade,D N Black,F L de Castro Portugal,L Enjuanes,W R Hess,C Mebus,A Ordas,D Rutili,J Sanchez Vizcaino,J. D. Vigário,P J Wilkinson,J. F. Moura Nunes,G Thomson +13 more
TL;DR: In 1921 MONTGOMerY reported that he had produced a fatal disease in pigs by inoculating extracts of various tissues taken from animals which had died from a condition which he named East African swine fever, which he showed was caused by a virus and that warthogs and bushpigs probably acted as natural carriers of the disease in Africa.
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African swine fever virus replication and genomics
TL;DR: African swine fever virus (ASFV) is a large icosahedral DNA virus which replicates predominantly in the cytoplasm of infected cells and a similar mechanism of replication to Poxviruses has been proposed for ASFV.
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African Swine Fever Virus Isolate, Georgia, 2007
Rebecca J. Rowlands,Vincent Michaud,Livio Heath,Geoff Hutchings,C.A.L. Oura,Wilna Vosloo,Rahana Dwarka,Tinatin Onashvili,Emmanuel Albina,Linda K. Dixon +9 more
TL;DR: The virus isolate introduced to the Caucasus in 2007 is closely related to a group of viruses, genotype II, circulating in Mozambique, Madagascar, and Zambia.
Journal ArticleDOI
Genotyping field strains of African swine fever virus by partial p72 gene characterisation.
Armanda D.S. Bastos,Marie-Louise Penrith,Catherine Crucière,J.L. Edrich,Geoff Hutchings,François Roger,Emmanuel Couacy-Hymann,G. R. Thomson +7 more
TL;DR: A PCR-based sequencing method was developed which permits detection and characterization of African swine fever virus (ASFV) variants within 5 and 48 h, respectively, of receipt of a clinical specimen, useful for molecular epidemiological clarification of ASF.